Results 101 to 110 of about 96,968 (259)

STUDIES ON THE SOLUBLE PRECIPITABLE SUBSTANCES OF VACCINIA [PDF]

, 1936
James Craigie, F. O. Wishart
openalex   +3 more sources

Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?

Viruses, 2015
The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal ...
Samantha Turnbull, Emma J. West, Karen J. Scott, Elizabeth Appleton, Alan Melcher, Christy Ralph   +5 more
doaj   +1 more source

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Anson, Donald S., Blanchard, Thomas, Blanchard, Tom J., Bridge, Simon H., Dennis, Mike J., Dowall, Stuart D., Getty, Brian, Sharpe, Sally A., Skinner, Michael A., Stewart, James P.   +9 more
core   +4 more sources

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, Volume 12, Issue 25, July 3, 2025.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Bartlett, Nathan W, Bowie, Andrew G, Fitzgerald, Katherine A, Haga, Ismar R, Maloney, Geraldine, Reading, Patrick C, Schröder, Martina, Smith, Geoffrey L, Stack, Julianne   +8 more
core   +2 more sources

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, Volume 12, Issue 26, July 10, 2025.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase [PDF]

, 1989
The regulation of antigen processing and presentation to MHC class I-restricted cytolytic T lymphocytes was studied in cells infected with murine cytomegalovirus. Recognition by cytolytic T lymphocytes of the phosphoprotein pp89, the immunodominant viral
Bernards, Borysiewicz, Braciale, Burgert, Cochet, Coupar, De Plaen, Del Val, Ebeling, Germain, Germain, Gooding, Gregory, Haddada, Hansen, Jennings, Jonjic, Keil, Keil, Keil, Konrad Münch, Koszinowski, Koszinowski, Kotwal, Lemke, Lurquin, Margarita Del Val, Maryanski, Masucci, Matthias J. Reddehase, Reddehase, Reddehase, Reddehase, Reddehase, Reddehase, Rice, Schickendanz, Schrier, Schwartz, Shimonkevitz, Stinski, Tanaka, Townsend, Townsend, Townsend, Ulrich H. Koszinowski, Vaessen, Volkmer, Yewdell   +48 more
core   +1 more source

High Cell Density Perfusion Process of Quail Cells Producing Oncolytic rVSV‐NDV

Engineering in Life Sciences, Volume 25, Issue 7, July 2025.
ABSTRACT Oncolytic viruses as agents for the treatment of various types of cancer have demonstrated their potential in many clinical studies over the past decades. In particular, rVSV‐NDV (a recombinant vesicular stomatitis virus [VSV] construct with fusogenic Newcastle disease virus glycoproteins) shows promising preclinical results.
Lennart Jacobtorweihe, Sven Göbel, Markus Wolschek, Jennifer Altomonte, Udo Reichl, Yvonne Genzel   +5 more
wiley   +1 more source

Does limited virucidal activity of biocides include duck hepatitis B virucidal action? [PDF]

, 2012
BACKGROUND: There is agreement that the infectivity assay with the duck hepatitis B virus (DHBV) is a suitable surrogate test to validate disinfectants for hepatitis B virucidal activity.
Bust, Uwe, Glück, Brigitte, Rabenau, Holger, Sauerbrei, Andreas, Schacke, Michael, Wutzler, Peter   +5 more
core   +1 more source

Optical Method for the Detection of Viral RNA Using an Optical Fiber Sensor

Journal of Biophotonics, Volume 18, Issue 7, July 2025.
This study presents a fiber‐optic sensor with a microsphere tip functionalized with a gold layer and oligonucleotide probes for detecting SARS‐CoV‐2 RNA at concentrations as low as 10−12 M in near real time. ABSTRACT This study introduces a fiber‐optic sensor functionalized with a sensing probe for SARS‐CoV‐2 RNA detection.
Patryk Sokołowski, Paweł Wityk, Joanna Raczak‐Gutknecht, Wiktoria Brzezińska, Michał Sobaszek, Paweł Kalinowski, Sebastian Garcia‐Galan, Małgorzata Szczerska   +7 more
wiley   +1 more source