Results 101 to 110 of about 98,253 (278)
Viral infections of the central nervous system (CNS) lead to a broad range of pathologies. CNS infections with Orthopox viruses have been mainly documented as an adverse reaction to smallpox vaccination with vaccinia virus. To date, there is insufficient
Tomer Israely +12 more
doaj +1 more source
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei +12 more
wiley +1 more source
The Conditions of Primary Infection Define the Load of Latent Viral Genome in Organs and the Risk of Recurrent Cytomegalovirus Disease [PDF]
Recurrence of cytomegalovirus (CMV) from latency is a frequent cause of disease in immunocompromised patients. To date, there is no explanation for the diversity in the clinical manifestations.
Balthesen, Monika +5 more
core +4 more sources
Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl‐transferase [PDF]
Marcos de la Peña +2 more
openalex +1 more source
A deep learning framework called MolVisGNN is proposed to fuse 3D molecular visual information of drugs with multi‐source features, which proves the importance of 3D molecular visual information of drugs and the advancedness of this model in the field of drug discovery, and provides a reference for how to more comprehensively express small molecule ...
Zimai Zhang +9 more
wiley +1 more source
Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease
Although smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox) global outbreak.
Rajini R. Mudhasani +17 more
doaj +1 more source
Signalling C-Type Lectins in Antimicrobial Immunity [PDF]
Funding: This work was funded by the Wellcome Trust, Medical Research Council and the University of Aberdeen. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ...
Brown, Gordon D., Drummond, Rebecca A.
core +2 more sources
Zoonotic Vaccinia Virus: Clinical and Immunological Characteristics in a Naturally Infected Patient [PDF]
Giliane S. Trindade +10 more
openalex +1 more source
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen +5 more
wiley +1 more source

