Results 41 to 50 of about 76,843 (254)

STUDIES IN VACCINIA. [PDF]

The Lancet, 1922
n ...
openaire   +2 more sources

Oncolytic vaccinia virus as a vector for therapeutic sodium iodide symporter gene therapy in prostate cancer

Gene Therapy, 2016
Oncolytic strains of vaccinia virus are currently in clinical development with clear evidence of safety and promising signs of efficacy. Addition of therapeutic genes to the viral genome may increase the therapeutic efficacy of vaccinia. We evaluated the
D. Mansfield, J. Kyula, N. Rosenfelder, J. Chao-Chu, Gabriela Kramer-Marek, Aadil Khan, V. Roulstone, M. McLaughlin, A. Melcher, R. Vile, H. Pandha, Vincent Khoo, Vincent Khoo, Vincent Khoo, Kevin J Harrington, Kevin J Harrington   +15 more
semanticscholar   +1 more source

A Quadrivalent mRNA Immunization Elicits Potent Immune Responses against Multiple Orthopoxviral Antigens and Neutralization of Monkeypox Virus in Rodent Models

Vaccines
The global outbreak of the 2022 monkeypox virus infection of humans and the 2023 documentation of a more virulent monkeypox in the Democratic Republic of the Congo raised public health concerns about the threat of human-to-human transmission of zoonotic ...
Caixia Su, Sha Li, Yang Wen, Xiya Geng, Quanyi Yin, Yun Wang, Yelin Xiong, Zhihua Liu   +7 more
doaj   +1 more source

Plasmablast, Memory B Cell, CD4+ T Cell, and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine

Vaccines, 2020
Background: Vaccinia is known to induce antibody and cellular responses. Plasmablast, circulating follicular helper T (cTFH) cells, cytokine-expressing CD4 T cells, and memory B cells were compared between subcutaneous (SC) and needle-free jet injection (
Evan J. Anderson, Lilin Lai, Jens Wrammert, Sarah Kabbani, Yongxian Xu, Lalita Priyamvada, Heather Hill, Johannes B. Goll, Travis L. Jensen, Carol Kao, Inci Yildirim, Nadine Rouphael, Lisa Jackson, Mark J. Mulligan   +13 more
doaj   +1 more source

Progressive Vaccinia [PDF]

Clinical Infectious Diseases, 2003
The resumption of smallpox vaccination for health care workers and other first responders has raised concern about the occurrence of complications in people with immunodeficiency disorders, including those infected with human immunodeficiency virus.
Mike, Bray, Mary E, Wright
openaire   +2 more sources

Should Remaining Stockpiles of Smallpox Virus (Variola) Be Destroyed?

Emerging Infectious Diseases, 2011
In 2011, the World Health Organization will recommend the fate of existing smallpox stockpiles, but circumstances have changed since the complete destruction of these cultures was first proposed.
Raymond S. Weinstein
doaj   +1 more source

Polymeric Cups for Cavitation-mediated Delivery of Oncolytic Vaccinia Virus

Molecular Therapy, 2016
Oncolytic viruses (OV) could become the most powerful and selective cancer therapies. However, the limited transport of OV into and throughout tumors following intravenous injection means their clinical administration is often restricted to direct ...
Rachel Myers, C. Coviello, P. Erbs, Johann Foloppe, C. Rowe, J. Kwan, C. Crake, S. Finn, E. Jackson, J. Balloul, Colin Story, C. Coussios, R. Carlisle   +12 more
semanticscholar   +1 more source

A Comprehensive Lateral Flow Strip Assay for On‐Site mRNA Vaccine Quality Control in Decentralized Manufacturing

Advanced Science, EarlyView.
A rapid, portable lateral flow strip assay for on‐site mRNA quality control is developed, enabling sequence‐independent analysis of 5' capping, integrity, and LNPs encapsulation efficiency. This cost‐effective method offers real‐time stability monitoring, reduced sample requirements, and comparable accuracy to standard techniques, enhancing ...
Dengwang Luo, Ziwei Zhang, Jing Guo, Jieli Zhang, Arong Huang, Qinghao Cao, Jiangnan Zheng, Yingjin Yuan, Daming Wang, Yuhong Cao   +9 more
wiley   +1 more source

Secondary and Tertiary Transmission of Vaccinia Virus from US Military Service Member

Emerging Infectious Diseases, 2011
During February and March 2010, the New York State Department of Health investigated secondary and tertiary vaccinia contact transmission from a military vaccinee to 4 close contacts.
Gregory E. Young, Christina M. Hidalgo, Ann Sullivan-Frohm, Cynthia Schulte, Stephen Davis, Cassandra Kelly-Cirino, Christina Egan, Kimberly Wilkins, Ginny L. Emerson, Kimberly Noyes, Debra Blog   +10 more
doaj   +1 more source

Ribosome Profiling Reveals Translational Upregulation of Cellular Oxidative Phosphorylation mRNAs during Vaccinia Virus-Induced Host Shutoff

Journal of Virology, 2016
Vaccinia virus infection causes a host shutoff that is marked by global inhibition of host protein synthesis. Though the host shutoff may facilitate reallocation of cellular resources for viral replication and evasion of host antiviral immune responses ...
Aimei Dai, Shuai Cao, Pragyesh Dhungel, Yizhao Luan, Yizhi Liu, Zhi Xie, Zhilong Yang   +6 more
semanticscholar   +1 more source