Results 71 to 80 of about 76,843 (254)

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity.

Journal of General Virology, 2013
Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity.
Geoffrey L. Smith, Camilla T. O. Benfield, Carlos Maluquer de Motes, Michela Mazzon, S. Ember, B. Ferguson, Rebecca P. Sumner   +6 more
semanticscholar   +1 more source

Artificial Intelligence and the Evolving Landscape of Immunopeptidomics

PROTEOMICS – Clinical Applications, EarlyView.
ABSTRACT Background Immunopeptidomics is the large‐scale study of peptides presented by major histocompatibility complex (MHC) molecules and plays a central role in neoantigen discovery and cancer immunotherapy. However, the complexity of mass spectrometry data, the diversity of peptide sources, and variability in immune responses present major ...
Thanh Hoa Vo, Edel McNeela, Orla O'Donovan, Sweta Rani, Jai Prakash Mehta   +4 more
wiley   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Genomic identification of human vaccinia virus keratoconjunctivitis and its importance as a laboratory-acquired infection

Indian Journal of Ophthalmology, 2016
Context: Vaccinia virus (VACV) is a member of orthopoxvirus genus of the family Poxviridae. VACVs are enveloped, double-stranded DNA viruses. Several species of this family, for example, molluscum contagiosum, smallpox, deerpox, horsepox, rabbitpox, and ...
Zahra Movahedi Motlagh, Azam Mokhtari, Mohammadreza Mahzounieh   +2 more
doaj   +1 more source

De novo Fatty Acid Biosynthesis Contributes Significantly to Establishment of a Bioenergetically Favorable Environment for Vaccinia Virus Infection

PLoS Pathogens, 2014
The poxvirus life cycle, although physically autonomous from the host nucleus, is nevertheless dependent upon cellular functions. A requirement for de novo fatty acid biosynthesis was implied by our previous demonstration that cerulenin, a fatty acid ...
Matthew D. Greseth, P. Traktman
semanticscholar   +1 more source

Prevalence, Comorbidities, and Current Management of Chronic Spontaneous Urticaria in Japan: Retrospective Claims Database Study

The Journal of Dermatology, EarlyView.
ABSTRACT Chronic spontaneous urticaria (CSU) affects 0.5%–1.0% of the population worldwide. However, information on the prevalence, comorbidities, and treatment patterns of CSU in Japan is limited. This observational study consisted of a cross‐sectional and longitudinal part.
Atsushi Fukunaga, Yuko Kishi, Yoshinori Sunaga, Kazuhiko Arima   +3 more
wiley   +1 more source

Optimizing Microneutralization and IFN-γ ELISPOT Assays to Evaluate Mpox Immunity

Vaccines
Background: Available assays to measure pox virus neutralizing antibody titers are laborious and take up to 5 days. In addition, assays to measure T cell responses require the use of specific antigens, which may not be the same for all pox viruses.
Yinyi Yu, Krystal Meza, Chase Colbert, Daniel F. Hoft, Anna Jaunarajs, Azra Blazevic, Sharon E. Frey, Getahun Abate   +7 more
doaj   +1 more source

LATENT VACCINIA. [PDF]

The Lancet, 1902
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openaire   +1 more source

Progressive Vaccinia Treated with Ribavirin and Vaccinia Immune Globulin [PDF]

Clinical Infectious Diseases, 1997
A 67-year-old man with metastatic melanoma and chronic lymphocytic leukemia was inadvertently given a vaccinia melanoma oncolysate vaccination. He developed progressive vaccinia at the site of inoculation. The lesion started to heal only when he was treated with ribavirin.
John Ferguson, Anthony L. Cunningham, William D. Rawlinson, Alison M. Kesson   +3 more
openaire   +3 more sources

Pixelated pathologies: Camera trapping as a tool for monitoring wildlife health

Journal of Applied Ecology, EarlyView.
Given the increasing emergence of diseases, some with conservation and public health implications, improving and expanding wildlife health surveillance strategies is imperative. Camera trapping is particularly relevant for detecting new outbreaks, monitoring high‐risk zones and evaluating risk mitigation measures. Abstract Camera trapping has become an
Patricia Barroso, Pablo Palencia
wiley   +1 more source