Results 71 to 80 of about 96,968 (259)

Modification of H-2 Antigenic Sites by Enzymatic Treatment Influences Virus-Specific Target Cell Lysis [PDF]

, 1976
Vaccinia virus-infected cells were treated enzymatically to remove H-2 antigenic sites. The effect of this procedure on virus-specific cell-mediated cytolysis (CMC) and virus-specific antibody-mediated cytolysis (AMC) was tested. Due to the inhibition of
Ertl, H., Koszinowski, Ulrich H.
core  

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Proliferative and neoplastic aural pinna masses in a collection of African giant pouched rats (Cricetomys ansorgei)

Veterinary Record Case Reports, EarlyView.
Abstract This case series describes aural lesions occurring in five African giant pouched rats (Cricetomys ansorgei) residing at a single zoological institution in southern California. Age of onset ranged from 3 to 7 years. Lesions occurred as single or multiple masses on one or both ears. A single case also developed a nasal mass.
Amanda Burke, Alison Righton, Tess Rooney, Matt Marinkovich, Garrett Fraess   +4 more
wiley   +1 more source

A Pseudovirus Nanoparticle Displaying the Vaccinia Virus L1 Protein Elicited High Neutralizing Antibody Titers and Provided Complete Protection to Mice against Mortality Caused by a Vaccinia Virus Challenge

Vaccines
The recent worldwide incidence of mpox infection and concerns about future emerging variants of mpox viruses highlight the need for the development of a new generation of mpox vaccines.
Pengwei Huang, Ming Xia, Frank S. Vago, Wen Jiang, Ming Tan   +4 more
doaj   +1 more source

Plasmablast, Memory B Cell, CD4+ T Cell, and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine

Vaccines, 2020
Background: Vaccinia is known to induce antibody and cellular responses. Plasmablast, circulating follicular helper T (cTFH) cells, cytokine-expressing CD4 T cells, and memory B cells were compared between subcutaneous (SC) and needle-free jet injection (
Evan J. Anderson, Lilin Lai, Jens Wrammert, Sarah Kabbani, Yongxian Xu, Lalita Priyamvada, Heather Hill, Johannes B. Goll, Travis L. Jensen, Carol Kao, Inci Yildirim, Nadine Rouphael, Lisa Jackson, Mark J. Mulligan   +13 more
doaj   +1 more source

Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions [PDF]

, 1985
We have obtained a vaccinia virus recombinant which contains a complete cDNA copy of the 26S RNA of Sindbis virus within the thymidine kinase gene of the vaccinia virus genome.
Franke, Christine A., Hruby, Dennis E., Rice, Charles M., Strauss, James H.   +3 more
core  

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, EarlyView.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Attenuation of Vaccinia Virus [PDF]

Acta Naturae, 2015
Since 1980, in the post-smallpox vaccination era the human population has become increasingly susceptible compared to a generation ago to not only the variola (smallpox) virus, but also other zoonotic orthopoxviruses. The need for safer vaccines against orthopoxviruses is even greater now.
YAKUBITSKIY S.N., KOLOSOVA I.V., MAKSYUTOV R.A., SHCHELKUNOV S.N.   +3 more
openaire   +4 more sources

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

The viral protein VP6 of rotavirus coinmunoprecipated with HSC70 in cels MA104

Revista de la Facultad de Medicina, 2006
Introduction: Rotaviruses are the main cause of gastroenteritis in children under five years old. At this moment is unknown how these viruses entry to host cell. The heat shock cognate protein HSC70 has been involved in rotavirus cell entry. However, the
Luz Stella Rodríguez, Carlos Arturo Guerrero Fonseca   +1 more
doaj