Results 41 to 50 of about 2,460 (182)

The Unexpected Actor? Civil‐Military Relations and Regulatory Agency Control in Brazil

open access: yesGovernance, Volume 39, Issue 1, January 2026.
ABSTRACT Democratic backsliding around the world has sparked debate about its impact on public administration and governance. This article explores a growing yet less visible phenomenon threatening democracy. It examines the influence exerted by authoritarian populists over autonomous regulatory agencies through militarized patronage, that is, the ...
Bruno Queiroz Cunha   +2 more
wiley   +1 more source

Induction of IL‐12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol‐Anchored Mucin‐Like Glycoproteins and Potentiated by IFN‐γ and CD40‐CD40L Interactions

open access: yesMediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is characterized by immunopathology driven by IFN‐γ secreting Th1‐like T cells. T. cruzi has a thick coat of mucin‐like glycoproteins covering its surface, which plays an important role in parasite invasion and host immunomodulation. It has been extensively described that T.
Lúcia Cristina Jamli Abel   +8 more
wiley   +1 more source

Broad innate immune activation enhances the protective efficacy of rBCG-LTAK63 against Mycobacterium tuberculosis

open access: yesFrontiers in Immunology
IntroductionTuberculosis (TB) continues to be one of the leading infectious causes of mortality world-wide, while the Bacillus Calmette–Guérin (BCG) vaccine provides variable protection.
Ana Carolina de Oliveira Carvalho   +8 more
doaj   +1 more source

Chimeras could help in the fight against leptospirosis

open access: yeseLife, 2018
Understanding the structure of an antigen can guide the design of improved antigen-based vaccines.
Jademilson C Santos   +1 more
doaj   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

open access: yesVeterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis   +9 more
wiley   +1 more source

Metabolic Profile Associated With Encystation in Acanthamoeba

open access: yesJournal of Eukaryotic Microbiology, Volume 72, Issue 5, September/October 2025.
ABSTRACT The genus Acanthamoeba includes widespread protozoa that can cause severe infections in humans. Their ability to form resistant cysts within infected tissues complicates treatment, making it essential to understand the encystation process for developing effective therapeutic strategies.
Cecília Cirelli   +8 more
wiley   +1 more source

In Silico Analysis of Genetic VapC Profiles from the Toxin-Antitoxin Type II VapBC Modules among Pathogenic, Intermediate, and Non-Pathogenic Leptospira

open access: yesMicroorganisms, 2019
Pathogenic Leptospira spp. is the etiological agent of leptospirosis. The high diversity among Leptospira species provides an array to look for important mediators involved in pathogenesis.
Alexandre P. Y. Lopes   +5 more
doaj   +1 more source

Cytotoxic Signature and IFN‐γ Production Dominate CD4+ T‐Cell Response During Human Toxoplasmosis

open access: yesImmunology, Volume 175, Issue 2, Page 151-164, June 2025.
Overview of CD4+ T‐cell subsets in patients with toxoplasmosis. Schematic drawing summarising the most important alterations in CD4+ T‐cell subsets, illustrated in different colours, from patients in distinct stages of toxoplasmosis, represented with different colours, with (lesion) or without (no lesion) ocular manifestations.
Priscilla Miranda Henriques   +14 more
wiley   +1 more source

CRISPR/Cas9 Approach to Generate an Auxotrophic BCG Strain for Unmarked Expression of LTAK63 Adjuvant: A Tuberculosis Vaccine Candidate

open access: yesFrontiers in Immunology, 2022
Tuberculosis is one of the deadliest infectious diseases and a huge healthcare burden in many countries. New vaccines, including recombinant BCG-based candidates, are currently under evaluation in clinical trials.
Luana Moraes   +9 more
doaj   +1 more source

Asymptomatic SARS‐CoV‐2 Infection: Association Involving the HLA‐B*15 Allele Group in Brazilian Individuals

open access: yesHLA, Volume 105, Issue 6, June 2025.
ABSTRACT The aim of this study was to investigate the influence of HLA‐A, ‐B and ‐C polymorphisms on the clinical course of SARS‐CoV‐2 infection and on the progression of COVID‐19 in a population from southeastern Brazil. This study included 478 unvaccinated individuals. Of these, 369 were hospitalised with critical/severe (n = 309) or moderate/mild (n 
Christiane Maria Ayo   +8 more
wiley   +1 more source

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