Results 41 to 50 of about 2,519 (182)

Induction of IL‐12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol‐Anchored Mucin‐Like Glycoproteins and Potentiated by IFN‐γ and CD40‐CD40L Interactions

Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is characterized by immunopathology driven by IFN‐γ secreting Th1‐like T cells. T. cruzi has a thick coat of mucin‐like glycoproteins covering its surface, which plays an important role in parasite invasion and host immunomodulation. It has been extensively described that T.
Lúcia Cristina Jamli Abel, Ludmila Rodrigues Pinto Ferreira, Isabela Cunha Navarro, Monique Andrade Baron, Jorge Kalil, Ricardo Tostes Gazzinelli, Luiz Vicente Rizzo, Edecio Cunha-Neto, Christophe Chevillard   +8 more
wiley   +1 more source

Chimeras could help in the fight against leptospirosis

eLife, 2018
Understanding the structure of an antigen can guide the design of improved antigen-based vaccines.
Jademilson C Santos, Ana Lucia TO Nascimento   +1 more
doaj   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

Metabolic Profile Associated With Encystation in Acanthamoeba

Journal of Eukaryotic Microbiology, Volume 72, Issue 5, September/October 2025.
ABSTRACT The genus Acanthamoeba includes widespread protozoa that can cause severe infections in humans. Their ability to form resistant cysts within infected tissues complicates treatment, making it essential to understand the encystation process for developing effective therapeutic strategies.
Cecília Cirelli, Isabela Aurora Rodrigues, Jéssica Gardone Vitório, Filipe Fideles Duarte‐Andrade, Gisele André Baptista Canuto, Leiliane Coelho André, Juliano Simões de Toledo, Ana Paula Fernandes, Adriana Oliveira Costa   +8 more
wiley   +1 more source

In vitro Evidence of Human Immune Responsiveness Shows the Improved Potential of a Recombinant BCG Strain for Bladder Cancer Treatment

Frontiers in Immunology, 2019
The live attenuated mycobacterial strain BCG, in use as vaccine against tuberculosis, is considered the gold standard for primary therapy of carcinoma in situ of the bladder.
Dunia Rodriguez, Cibelly Goulart, Ana C. Pagliarone, Eliane P. Silva, Eliane P. Silva, Priscila S. Cunegundes, Priscila S. Cunegundes, Ivan P. Nascimento, Ricardo C. Borra, Waldely O. Dias, Aldo Tagliabue, Diana Boraschi, Luciana C. C. Leite   +12 more
doaj   +1 more source

Broad innate immune activation enhances the protective efficacy of rBCG-LTAK63 against Mycobacterium tuberculosis

Frontiers in Immunology
IntroductionTuberculosis (TB) continues to be one of the leading infectious causes of mortality world-wide, while the Bacillus Calmette–Guérin (BCG) vaccine provides variable protection.
Ana Carolina de Oliveira Carvalho, Monalisa Martins Trentini, Dunia Rodriguez, Lázaro Moreira Marques-Neto, Paulo Henrique Santana Silveira, Nancy Starobinas, Sergio Costa Oliveira, Luciana Cezar de Cerqueira Leite, Alex Issamu Kanno   +8 more
doaj   +1 more source

In Silico Analysis of Genetic VapC Profiles from the Toxin-Antitoxin Type II VapBC Modules among Pathogenic, Intermediate, and Non-Pathogenic Leptospira

Microorganisms, 2019
Pathogenic Leptospira spp. is the etiological agent of leptospirosis. The high diversity among Leptospira species provides an array to look for important mediators involved in pathogenesis.
Alexandre P. Y. Lopes, Bruna O. P. Azevedo, Rebeca C. Emídio, Deborah K. Damiano, Ana L. T. O. Nascimento, Giovana C. Barazzone   +5 more
doaj   +1 more source

Cytotoxic Signature and IFN‐γ Production Dominate CD4+ T‐Cell Response During Human Toxoplasmosis

Immunology, Volume 175, Issue 2, Page 151-164, June 2025.
Overview of CD4+ T‐cell subsets in patients with toxoplasmosis. Schematic drawing summarising the most important alterations in CD4+ T‐cell subsets, illustrated in different colours, from patients in distinct stages of toxoplasmosis, represented with different colours, with (lesion) or without (no lesion) ocular manifestations.
Priscilla Miranda Henriques, Gregório Guilherme Almeida, Inga Rimkute, Luara Isabela dos Santos, Thomas Liechti, Ana Paula Marino, Isabela Natália Pascoal Campos do Vale, Daniel Vitor Vasconcelos‐Santos, Olindo Assis Martins‐Filho, Ricardo Tostes Gazzinelli, Mario Roederer, Alan Sher, Andréa Teixeira‐Carvalho, Dragana Jankovic, Lis Ribeiro do Valle Antonelli   +14 more
wiley   +1 more source

ANÁLISIS CLÍNICO-EPIDEMIOLÓGICO DE LA ATENCIÓN EN UN CENTRO DE REFERENCIA EM INMUNOBIOLÓGICOS ESPECIALES EM LA AMAZONIA

Cogitare Enfermagem, 2020
Objective: to describe the clinical-epidemiological profile of the care service at the Reference Center for Special Immunobiologicals of Hospital in the Amazon.
Paula Rachel Neves Espindola, Gabrielly Lisboa da Silva Soares, Elizabeth do Socorro Pantoja Pereira, Kárila Larissa Pereira de Oliveira, Jaira Ataide dos Santos de Brito, Dinair Leal da Hora, Tânia do Socorro Souza Chaves   +6 more
doaj   +1 more source

Asymptomatic SARS‐CoV‐2 Infection: Association Involving the HLA‐B*15 Allele Group in Brazilian Individuals

HLA, Volume 105, Issue 6, June 2025.
ABSTRACT The aim of this study was to investigate the influence of HLA‐A, ‐B and ‐C polymorphisms on the clinical course of SARS‐CoV‐2 infection and on the progression of COVID‐19 in a population from southeastern Brazil. This study included 478 unvaccinated individuals. Of these, 369 were hospitalised with critical/severe (n = 309) or moderate/mild (n 
Christiane Maria Ayo, Henrique Magalhães, Marcos Paulo Miola, Cinara Cássia Brandão, Maurício Lacerda Nogueira, Cássia Fernanda Estofolete, Victor Hugo de Souza, Jeane Eliete Laguila Visentainer, Luiz Carlos de Mattos   +8 more
wiley   +1 more source