Recombinant BCG to Enhance Its Immunomodulatory Activities [PDF]
Vaccines, 2022 The bacillus Calmette–Guérin (BCG) is an attenuated Mycobacterium bovis derivative that has been widely used as a live vaccine against tuberculosis for a century.
Magdalena Kowalewicz-Kulbat +1 more
doaj +4 more sources
Recombinant BCG Expressing the Subunit 1 of Pertussis Toxin Induces Innate Immune Memory and Confers Protection against Non-Related Pathogens [PDF]
Vaccines, 2022 BCG has shown the ability to induce protection against unrelated pathogens, which likely depends on an immune mechanism known as innate immune memory or trained immunity.
Alex I. Kanno +3 more
doaj +2 more sources
Enhanced immunogenicity in mouse by recombinant BCG prime and protein boost based on latency antigen Rv1733c and/or reactivation antigen RpfE [PDF]
BMC Infectious DiseasesBackground Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB), but it fails to prevent the establishment and reactivation of latent TB.
Mitra Ashayeripanah +4 more
doaj +2 more sources
A recombinant BCG with surface-displayed antigen induces humoral and cellular immune responses [PDF]
Scientific ReportsBacillus Calmette-Guérin (BCG) is an attenuated vaccine widely used for tuberculosis prevention. While BCG has long been perceived as an intracellular candidate vector for delivering antigens against infectious diseases and cancers, challenges persist in
Jin-Yu Zhang +9 more
doaj +2 more sources
Vaccine-Induced Subcutaneous Granulomas in Goats Reflect Differences in Host-Mycobacterium Interactions between BCG- and Recombinant BCG-Derivative Vaccines. [PDF]
Int J Mol Sci, 2022 Tuberculous granulomas are highly dynamic structures reflecting the complex host–mycobacterium interactions. The objective of this study was to compare granuloma development at the site of vaccination with BCG and its recombinant derivatives in goats.
Liebler-Tenorio EM +9 more
europepmc +6 more sources
Characterization of the Protective Immune Responses Conferred by Recombinant BCG Overexpressing Components of Mycobacterium tuberculosis Sec Protein Export System [PDF]
Vaccines, 2022 Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is the only approved vaccine against tuberculosis (TB). However, its efficacy in preventing pulmonary TB in adults is limited.
Annuurun Nisa +4 more
doaj +2 more sources
In vitro Evidence of Human Immune Responsiveness Shows the Improved Potential of a Recombinant BCG Strain for Bladder Cancer Treatment [PDF]
Frontiers in Immunology, 2019 The live attenuated mycobacterial strain BCG, in use as vaccine against tuberculosis, is considered the gold standard for primary therapy of carcinoma in situ of the bladder.
Dunia Rodriguez +12 more
doaj +2 more sources
DNA Subunit Vaccine and Recombinant BCG Based on Mycobacterial Lipoprotein LprO Enhance Anti-Tuberculosis Protection in the Lungs of Mice [PDF]
VaccinesBackground/Objectives: Over the past two centuries, tuberculosis (TB) has been responsible for approximately one billion deaths and continues to represent a significant global health challenge.
Weili Huang +13 more
doaj +2 more sources
Recombinant BCG Overexpressing phoP-phoR Confers Enhanced Protection against Tuberculosis. [PDF]
Mol Ther, 2018 The live tuberculosis vaccine Mycobacterium bovis BCG (Bacille Calmette-Guérin) comprises a number of genetically distinct substrains. In BCG-Prague, phoP of the PhoP-PhoR two-component system is a pseudogene due to a single insertion mutation. We hypothesized that this mutation partially accounts for the low immunogenicity of BCG-Prague observed in ...
Ahn SK +6 more
europepmc +4 more sources
Recombinant BCG expressing the LTAK63 adjuvant induces increased early and long-term immune responses against Mycobacteria [PDF]
Human Vaccines & Immunotherapeutics, 2020 The development of more effective vaccines against Mycobacterium tuberculosis has become a world priority. Previously, we have shown that a recombinant BCG expressing the LTAK63 adjuvant (rBCG-LTAK63) displayed higher protection than BCG against ...
Carina Carvalho Dos Santos +4 more
doaj +2 more sources