BCG vaccination: a role for vitamin D? [PDF]
, 2011 BCG vaccination is administered in infancy in most countries with the aim of providing protection against tuberculosis. There is increasing interest in the role of vitamin D in immunity to tuberculosis.
Hazel M. Dockrell +35 more
core +1 more source
Construction, stability and immunogenicity of recombinant BCG expressing HIV-1 subtype C gag under the control of MtrA promoter, with or without the leader sequences [PDF]
, 2011 This study aimed to compare recombinant mycobacteria expressing HIV-1 gag under the control of different promoters and leader sequences. This was done to determine whether the genetic stability of the recombinant mycobacteria could be improved by ...
Lebeko, Maribanyana R
core +1 more source
EB virus-positive tumors are inhibited by rBCG expressing hGM-CSF and LMP2A
Human Vaccines & Immunotherapeutics, 2020 For the development of safe and effective EBV (Epstein-Barr virus) vaccines, the Ag85A signal peptide from M. tuberculosis H37Rv was used to construct a recombinant secretory BCG (Bacillus Chalmette-Guérin) plasmid. The Ag85A gene, fused to the EBV LMP2A
Yingchun Yan +11 more
doaj +1 more source
Vaccination with recombinant Mycobacterium tuberculosis PknD attenuates bacterial dissemination to the brain in guinea pigs. [PDF]
PLoS ONE, 2013 We have previously identified Mycobacterium tuberculosis PknD to be an important virulence factor required for the pathogenesis of central nervous system (CNS) tuberculosis (TB).
Ciaran Skerry +6 more
doaj +1 more source
Adjuvants and Antigen-Delivery Systems for Subunit Vaccines against Tuberculosis
Vaccines, 2021 The only licensed vaccine against tuberculosis is BCG. However, BCG has failed to provide consistent protection against tuberculosis, especially pulmonary disease in adults.
Abu Salim Mustafa
doaj +1 more source
Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease. [PDF]
, 2015 Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a necrotizing disease of the skin and subcutaneous tissue, which is most prevalent in rural regions of West African countries.
Kerber, Sarah +11 more
core +3 more sources
Association between BCG-induced immunity and risk of TB disease [PDF]
, 2011 We tested the hypothesis that a lower frequency and profile of specific T cells induced by BCG vaccination at birth is associated with subsequent risk of developing ...
Kagina, Benjamin Mugo
core +1 more source
Next-Generation Vaccines Based on Bacille Calmette–Guérin
Frontiers in Immunology, 2018 Tuberculosis (TB), caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb), remains a major health threat. A live, attenuated mycobacterium known as Bacille Calmette–Guérin (BCG), derived from the causative agent of cattle TB ...
Natalie E. Nieuwenhuizen +1 more
doaj +1 more source
Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells. [PDF]
PLoS ONE, 2012 A safe and effective HIV vaccine is required to significantly reduce the number of people becoming infected with HIV each year. In this study wild type Mycobacterium bovis BCG Pasteur and an attenuated pantothenate auxotroph strain (BCGΔpanCD) that is ...
Rosamund Chapman +8 more
doaj +1 more source
Cellular immune responses to nine Mycobacterium tuberculosis vaccine candidates following intranasal vaccination. [PDF]
PLoS ONE, 2011 BACKGROUND: The identification of Mycobacterium tuberculosis vaccines that elicit a protective immune response in the lungs is important for the development of an effective vaccine against tuberculosis.
Suraj B Sable +9 more
doaj +1 more source