Results 31 to 40 of about 12,446 (175)

CHO expressed recombinant human lactoferrin as an adjuvant for BCG [PDF]

International Journal of Immunopathology and Pharmacology, 2015
Lactoferrin (LF), an iron binding protein with immune modulatory activities, has adjuvant activity to enhance vaccine efficacy. Tuberculosis (TB) is a pulmonary disease caused by the pathogen Mycobacterium tuberculosis (MTB). Progressive TB disease is clinically defined by damaging pulmonary pathology, a result of inflammation due to immune reactivity.
Shen-An, Hwang, Marian L, Kruzel, Jeffrey K, Actor   +2 more
openaire   +2 more sources

Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer. [PDF]

PLoS Neglected Tropical Diseases, 2015
Buruli ulcer, an emerging tropical disease caused by Mycobacterium ulcerans (MU), is characterized by disfiguring skin necrosis and high morbidity. Relatively little is understood about the mode of transmission, pathogenesis, or host immune responses to ...
Bryan E Hart, Laura P Hale, Sunhee Lee
doaj   +1 more source

The uraA locus and homologous recombination in Mycobacterium bovis BCG [PDF]

Journal of Bacteriology, 1993
Molecular genetic manipulation of mycobacteria would benefit from the isolation of mycobacterial genes that could serve both as genetic markers and as sequences used to target homologous integration of recombinant DNA into the genome. We isolated the Mycobacterium bovis BCG gene encoding orotidine-5'-monophosphate decarboxylase (OMP-DCase) by ...
A, Aldovini, R N, Husson, R A, Young
openaire   +2 more sources

Recombinant Mycobacterium bovis BCG as an HIV Vaccine Vector [PDF]

Current HIV Research, 2010
HIV-1 has resulted in a devastating AIDS pandemic. An effective HIV/AIDS vaccine that can be used to either, prevent HIV infection, control infection or prevent progression of the disease to AIDS is needed. In this review we discuss the use of Mycobacterium bovis BCG, the tuberculosis vaccine, as a vaccine vector for an HIV vaccine.
Rosamund, Chapman, Gerald, Chege, Enid, Shephard, Helen, Stutz, Anna-Lise, Williamson   +4 more
openaire   +2 more sources

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

Cell Proliferation, EarlyView.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song, Yujie Jiang, Yu Zhang, Danyi Ao, Chunjun Ye, Xiya Huang, Yingqiong Zhou, Hanle Yang, Ruolan Xia, Jiayuan Ai, Dandan Wan, Aiping Tong, Yuquan Wei, Xuemei He, Aqu Alu, Xiawei Wei   +15 more
wiley   +1 more source

Dendritic Cell Activity Driven by Recombinant Mycobacterium bovis BCG Producing Human IL-18, in Healthy BCG Vaccinated Adults

Journal of Immunology Research, 2015
Tuberculosis remains an enormous global burden, despite wide vaccination coverage with the Bacillus Calmette-Guérin (BCG), the only vaccine available against this disease, indicating that BCG-driven immunity is insufficient to protect the human ...
Piotr Szpakowski, Franck Biet, Camille Locht, Małgorzata Paszkiewicz, Wiesława Rudnicka, Magdalena Druszczyńska, Fabrice Allain, Marek Fol, Joël Pestel, Magdalena Kowalewicz-Kulbat   +9 more
doaj   +1 more source

Vaccination with a BCG strain overexpressing Ag85B protects cattle against Mycobacterium bovis challenge. [PDF]

PLoS ONE, 2012
Mycobacterium bovis is the causative agent of tuberculosis in cattle but also infects other animals, including humans. Previous studies in cattle have demonstrated that the protection induced by BCG is not complete.
Caroline Rizzi, María Verónica Bianco, Federico Carlos Blanco, Marcelo Soria, María José Gravisaco, Valeria Montenegro, Lucas Vagnoni, Bryce Buddle, Sergio Garbaccio, Fernando Delgado, Karen Silva Leal, Angel Adrián Cataldi, Odir Antônio Dellagostin, Fabiana Bigi   +13 more
doaj   +1 more source

A century of BCG vaccination: Immune mechanisms, animal models, non-traditional routes and implications for COVID-19

Frontiers in Immunology, 2022
Bacillus Calmette-Guerin (BCG) has been used as a vaccine against tuberculosis since 1921 and remains the only currently approved vaccine for this infection.
Shivani Singh, Shivani Singh, Shivani Singh, Noemi Alejandra Saavedra-Avila, Sangeeta Tiwari, Steven A. Porcelli, Steven A. Porcelli   +6 more
doaj   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, Volume 179, Issue 1, Page 54-71, September 2026.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

The immunogenicity of recombinant Mycobacterium smegmatis bearing BCG genes [PDF]

Microbiology, 1995
SUMMARYSpecific pathogen-free C57BL/6 mice infected with recombinantMycobacterium smegmatis(rM. smegmatis) bearing BCG genes showed increased splenic survival compared to those receiving the vector control (plasmid DNA only). The mouse-passaged rM. smegmatis(J3R) survived in peritoneal macrophages better than the vector control, regardless of whether ...
Valeria, Falcone, Effiong, Bassey, William, Jacobs, Frank, Collins   +3 more
openaire   +2 more sources