Results 21 to 30 of about 332,084 (209)

Heterologous Boosting With Listeria-Based Recombinant Strains in BCG-Primed Mice Improved Protection Against Pulmonary Mycobacterial Infection

Frontiers in Immunology, 2020
While Baccillus Calmette-Guerin (BCG) is used worldwide, tuberculosis (TB) is still a global concern due to the poor efficacy of BCG. Novel vaccine candidates are therefore urgently required.
Si-Jing Liu, Si-Jing Liu, Si-Cheng Tian, Si-Cheng Tian, Yun-Wen Zhang, Yun-Wen Zhang, Tian Tang, Tian Tang, Ju-Mei Zeng, Ju-Mei Zeng, Xiao-Yong Fan, Chuan Wang, Chuan Wang   +12 more
doaj   +1 more source

Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine

mBio, 2016
Mycobacterium bovis BCG is the only available vaccine for protection against tuberculosis (TB). While BCG protects children from severe disease, it has little impact on pulmonary disease in adults. A recombinant BCG vaccine BCG ΔureC::hly (strain VPM1002)
Helen A. Fletcher
doaj   +1 more source

CFP10: mFcγ2 as a novel tuberculosis vaccine candidate increases immune response in mouse [PDF]

Iranian Journal of Basic Medical Sciences, 2017
Objective(s): Despite treatment with antibiotics and vaccination with BCG, tuberculosis (TB) is still considered as one of the most important public health problems in the world.
Ali Asghar Baghani, Saman Soleimanpour, Hadi Farsiani, Arman Mosavat, Masoud Yousefi, Zahra Meshkat, Seyed Abdolrahim Rezaee, Saeid Amel Jamehdar, Mohammad Reza Akbari Eydgahi, Hamid Sadeghian, Kiarash Ghazvini   +10 more
doaj   +1 more source

CRISPR/Cas9 Approach to Generate an Auxotrophic BCG Strain for Unmarked Expression of LTAK63 Adjuvant: A Tuberculosis Vaccine Candidate

Frontiers in Immunology, 2022
Tuberculosis is one of the deadliest infectious diseases and a huge healthcare burden in many countries. New vaccines, including recombinant BCG-based candidates, are currently under evaluation in clinical trials.
Luana Moraes, Luana Moraes, Monalisa Martins Trentini, Dimitrios Fousteris, Dimitrios Fousteris, Silas Fernandes Eto, Ana Marisa Chudzinski-Tavassi, Ana Marisa Chudzinski-Tavassi, Luciana Cezar de Cerqueira Leite, Alex Issamu Kanno   +9 more
doaj   +1 more source

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: Different boosting intervals and implications for efficacy trials [PDF]

, 2007
Objectives. To investigate the safety and immunogenicity of boosting BCG with modified vaccinia Ankara expressing antigen 85A (MVA85A), shortly after BCG vaccination, and to compare this first with the immunogenicity of BCG vaccination alone and second
Whelan, KT, Pathan, Ansar A, Poulton Ian, Nicola C Alder, Sander Clare R., Whelan, Kathryn T, Kathryn T Whelan, Hill, Adrian, Fletcher, Helen A, Natalie E R Beveridge, Hill, AVS, Alder, NC, Fletcher, HA, Pathan Ansar A., Hill, Adrian VS, Sander, CR, Hill Adrian V. S., McShane Helen, Beveridge Natalie E. R., Pathan, AA, Hill, AV, Beveridge, NER, Alder, Nicola C, Clare R Sander, Helen McShane, Ansar A Pathan, Beveridge, NE, Ian Poulton, Poulton, Ian, Alder Nicola C., Whelan Kathryn T., Poulton, I, Sander, Clare R, Adrian V S Hill, Helen A Fletcher, Fletcher Helen A., McShane, H, Beveridge, Natalie ER, Fletcher, Helen, McShane, Helen   +39 more
core   +1 more source

Recombinant Mycobacterium bovis BCG

Vaccine, 2009
The Bacillus Calmette-Guerin (BCG) is an attenuated strain of Mycobacterium bovis that has been broadly used as a vaccine against human tuberculosis. This live bacterial vaccine is able to establish a persistent infection and induces both cellular and humoral immune responses. The development of mycobacterial genetic systems to express foreign antigens
Reginaldo G, Bastos, Sibele, Borsuk, Fabiana K, Seixas, Odir A, Dellagostin   +3 more
openaire   +2 more sources

Comparison of the Immunogenicity and Efficacy of rBCG-EPCP009, BCG Prime-EPCP009 Booster, and EPCP009 Protein Regimens as Tuberculosis Vaccine Candidates

Vaccines, 2023
Bacillus Calmette–Guérin (BCG) is the only widely used prophylactic tuberculosis (TB) vaccine that can prevent severe TB in infants. However, it provides poor protection in adults, and therefore, there is ongoing research into new TB vaccines and ...
Ruihuan Wang, Xueting Fan, Da Xu, Machao Li, Xiuqin Zhao, Bin Cao, Chengyu Qian, Jinjie Yu, Dan’ang Fang, Yujie Gu, Kanglin Wan, Haican Liu   +11 more
doaj   +1 more source

Flow cytometric detection of gamma interferon can effectively discriminate Mycobacterium bovis BCG-vaccinated cattle from M. bovis-infected cattle [PDF]

, 2006
Mycobacterium bovis is the causative agent of bovine tuberculosis, a disease that is increasing in incidence in United Kingdom cattle herds. In addition to increasing economic losses, the rise in bovine tuberculosis poses a human health risk. There is an
C. J. Howard, Howard, C J, Hope, J C; id_orcid, P. Sopp, J. C. Hope, Sopp, P   +5 more
core   +1 more source

Persistence of the immune response induced by BCG vaccination. [PDF]

, 2008
BACKGROUND: Although BCG vaccination is recommended in most countries of the world, little is known of the persistence of BCG-induced immune responses. As novel TB vaccines may be given to boost the immunity induced by neonatal BCG vaccination, evidence ...
Paul EM Fine, Sally Stenson, Branson Keith, Rose Blitz, Stenson, Sally, Dockrell Hazel M, Hazel M Dockrell, Floyd Sian, Maeve K Lalor, Rosemary E Weir, Gorak-Stolinska, Patricia, Sian Floyd, Fine, Paul EM, Ben-Smith Anne, Ben-Smith, Anne, Weir Rosemary E, Floyd, Sian, Blitz, Rose, Lalor Maeve K, Weir, Rosemary E, Fine Paul EM, Keith Branson, Anne Ben-Smith, Stenson Sally, Gorak-Stolinska Patricia, Lalor, Maeve K, Dockrell, Hazel M, Branson, Keith, Patricia Gorak-Stolinska, Blitz Rose   +29 more
core   +1 more source

Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity [PDF]

, 2011
The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post ...
Mbele, Prisca
core   +1 more source