CFP10: mFcγ2 as a novel tuberculosis vaccine candidate increases immune response in mouse [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Despite treatment with antibiotics and vaccination with BCG, tuberculosis (TB) is still considered as one of the most important public health problems in the world.
Ali Asghar Baghani +10 more
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Frontiers in Immunology, 2022 Tuberculosis is one of the deadliest infectious diseases and a huge healthcare burden in many countries. New vaccines, including recombinant BCG-based candidates, are currently under evaluation in clinical trials.
Luana Moraes +9 more
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Vaccines, 2023 Bacillus Calmette–Guérin (BCG) is the only widely used prophylactic tuberculosis (TB) vaccine that can prevent severe TB in infants. However, it provides poor protection in adults, and therefore, there is ongoing research into new TB vaccines and ...
Ruihuan Wang +11 more
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EB virus-positive tumors are inhibited by rBCG expressing hGM-CSF and LMP2A
Human Vaccines & Immunotherapeutics, 2020 For the development of safe and effective EBV (Epstein-Barr virus) vaccines, the Ag85A signal peptide from M. tuberculosis H37Rv was used to construct a recombinant secretory BCG (Bacillus Chalmette-Guérin) plasmid. The Ag85A gene, fused to the EBV LMP2A
Yingchun Yan +11 more
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Vaccination with recombinant Mycobacterium tuberculosis PknD attenuates bacterial dissemination to the brain in guinea pigs. [PDF]
PLoS ONE, 2013 We have previously identified Mycobacterium tuberculosis PknD to be an important virulence factor required for the pathogenesis of central nervous system (CNS) tuberculosis (TB).
Ciaran Skerry +6 more
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Adjuvants and Antigen-Delivery Systems for Subunit Vaccines against Tuberculosis
Vaccines, 2021 The only licensed vaccine against tuberculosis is BCG. However, BCG has failed to provide consistent protection against tuberculosis, especially pulmonary disease in adults.
Abu Salim Mustafa
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Next-Generation Vaccines Based on Bacille Calmette–Guérin
Frontiers in Immunology, 2018 Tuberculosis (TB), caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb), remains a major health threat. A live, attenuated mycobacterium known as Bacille Calmette–Guérin (BCG), derived from the causative agent of cattle TB ...
Natalie E. Nieuwenhuizen +1 more
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Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells. [PDF]
PLoS ONE, 2012 A safe and effective HIV vaccine is required to significantly reduce the number of people becoming infected with HIV each year. In this study wild type Mycobacterium bovis BCG Pasteur and an attenuated pantothenate auxotroph strain (BCGΔpanCD) that is ...
Rosamund Chapman +8 more
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Cellular immune responses to nine Mycobacterium tuberculosis vaccine candidates following intranasal vaccination. [PDF]
PLoS ONE, 2011 BACKGROUND: The identification of Mycobacterium tuberculosis vaccines that elicit a protective immune response in the lungs is important for the development of an effective vaccine against tuberculosis.
Suraj B Sable +9 more
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The Efficacy of the BCG Vaccine against Newly Emerging Clinical Strains of Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2015 To date, most new vaccines against Mycobacterium tuberculosis, including new recombinant versions of the current BCG vaccine, have usually been screened against the laboratory strains H37Rv or Erdman. In this study we took advantage of our recent work in
Marcela Henao-Tamayo +7 more
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