Results 41 to 50 of about 23,766 (215)

EB virus-positive tumors are inhibited by rBCG expressing hGM-CSF and LMP2A

Human Vaccines & Immunotherapeutics, 2020
For the development of safe and effective EBV (Epstein-Barr virus) vaccines, the Ag85A signal peptide from M. tuberculosis H37Rv was used to construct a recombinant secretory BCG (Bacillus Chalmette-Guérin) plasmid. The Ag85A gene, fused to the EBV LMP2A
Yingchun Yan, Qing-Jie Xue, Ang Liu, Hui Wang, Honghua Zhang, Shuang Wang, Longyu Zhao, Yunqing Li, Xiuzhen Li, Yuanyuan Yang, Ting Chen, Shigen Li   +11 more
doaj   +1 more source

CHO expressed recombinant human lactoferrin as an adjuvant for BCG [PDF]

International Journal of Immunopathology and Pharmacology, 2015
Lactoferrin (LF), an iron binding protein with immune modulatory activities, has adjuvant activity to enhance vaccine efficacy. Tuberculosis (TB) is a pulmonary disease caused by the pathogen Mycobacterium tuberculosis (MTB). Progressive TB disease is clinically defined by damaging pulmonary pathology, a result of inflammation due to immune reactivity.
Shen-An, Hwang, Marian L, Kruzel, Jeffrey K, Actor   +2 more
openaire   +2 more sources

Supernatants from lymphocytes stimulated with Bacillus Calmette-Guerin can modify the antigenicity of tumours and stimulate allogeneic T-cell responses [PDF]

, 2011
BACKGROUND: Reduced expression of class 1 human leucocyte antigens (HLA1) is often a mechanism by which tumours evade surveillance by the host immune system.
A G Dalgleish, A M Gravett, A Maraveyas, A Respa, AB Alexandroff, AG Dalgleish, AG Heriot, AK Abbas, B Seliger, BL Bennett, C Du, D Hrouda, D W Fowler, EA Bach, F Garrido, GP Dunn, IM Orme, J Copier, J Yang, JI Ellyard, JS Sebolt-Leopold, L De Monte, N Aptsiauri, P Smith, S Nicholson, T Cabrera, T Rodríguez, TB Tomasi, W M Liu, Wai M. Liu, WJ Storkus, WM Liu, Y Luo   +32 more
core   +1 more source

Next-Generation Vaccines Based on Bacille Calmette–Guérin

Frontiers in Immunology, 2018
Tuberculosis (TB), caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb), remains a major health threat. A live, attenuated mycobacterium known as Bacille Calmette–Guérin (BCG), derived from the causative agent of cattle TB ...
Natalie E. Nieuwenhuizen, Stefan H. E. Kaufmann   +1 more
doaj   +1 more source

Vaccination with recombinant Mycobacterium tuberculosis PknD attenuates bacterial dissemination to the brain in guinea pigs. [PDF]

PLoS ONE, 2013
We have previously identified Mycobacterium tuberculosis PknD to be an important virulence factor required for the pathogenesis of central nervous system (CNS) tuberculosis (TB).
Ciaran Skerry, Supriya Pokkali, Michael Pinn, Nicholas A Be, Jamie Harper, Petros C Karakousis, Sanjay K Jain   +6 more
doaj   +1 more source

Adjuvants and Antigen-Delivery Systems for Subunit Vaccines against Tuberculosis

Vaccines, 2021
The only licensed vaccine against tuberculosis is BCG. However, BCG has failed to provide consistent protection against tuberculosis, especially pulmonary disease in adults.
Abu Salim Mustafa
doaj   +1 more source

The uraA locus and homologous recombination in Mycobacterium bovis BCG [PDF]

Journal of Bacteriology, 1993
Molecular genetic manipulation of mycobacteria would benefit from the isolation of mycobacterial genes that could serve both as genetic markers and as sequences used to target homologous integration of recombinant DNA into the genome. We isolated the Mycobacterium bovis BCG gene encoding orotidine-5'-monophosphate decarboxylase (OMP-DCase) by ...
A, Aldovini, R N, Husson, R A, Young
openaire   +2 more sources

Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells. [PDF]

PLoS ONE, 2012
A safe and effective HIV vaccine is required to significantly reduce the number of people becoming infected with HIV each year. In this study wild type Mycobacterium bovis BCG Pasteur and an attenuated pantothenate auxotroph strain (BCGΔpanCD) that is ...
Rosamund Chapman, Enid Shephard, Helen Stutz, Nicola Douglass, Vasan Sambandamurthy, Irene Garcia, Bernhard Ryffel, William Jacobs, Anna-Lise Williamson   +8 more
doaj   +1 more source

The Efficacy of the BCG Vaccine against Newly Emerging Clinical Strains of Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2015
To date, most new vaccines against Mycobacterium tuberculosis, including new recombinant versions of the current BCG vaccine, have usually been screened against the laboratory strains H37Rv or Erdman. In this study we took advantage of our recent work in
Marcela Henao-Tamayo, Crystal A Shanley, Deepshikha Verma, Andrew Zilavy, Margaret C Stapleton, Synthia K Furney, Brendan Podell, Ian M Orme   +7 more
doaj   +1 more source

Cellular immune responses to nine Mycobacterium tuberculosis vaccine candidates following intranasal vaccination. [PDF]

PLoS ONE, 2011
BACKGROUND: The identification of Mycobacterium tuberculosis vaccines that elicit a protective immune response in the lungs is important for the development of an effective vaccine against tuberculosis.
Suraj B Sable, Mani Cheruvu, Subhadra Nandakumar, Sunita Sharma, Kakali Bandyopadhyay, Kathryn L Kellar, James E Posey, Bonnie B Plikaytis, Rama Rao Amara, Thomas M Shinnick   +9 more
doaj   +1 more source