The Efficacy of the BCG Vaccine against Newly Emerging Clinical Strains of Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2015 To date, most new vaccines against Mycobacterium tuberculosis, including new recombinant versions of the current BCG vaccine, have usually been screened against the laboratory strains H37Rv or Erdman. In this study we took advantage of our recent work in
Marcela Henao-Tamayo +7 more
doaj +1 more source
CHO expressed recombinant human lactoferrin as an adjuvant for BCG [PDF]
International Journal of Immunopathology and Pharmacology, 2015 Lactoferrin (LF), an iron binding protein with immune modulatory activities, has adjuvant activity to enhance vaccine efficacy. Tuberculosis (TB) is a pulmonary disease caused by the pathogen Mycobacterium tuberculosis (MTB). Progressive TB disease is clinically defined by damaging pulmonary pathology, a result of inflammation due to immune reactivity.
Shen-An, Hwang +2 more
openaire +2 more sources
Duration of Immunity against Mycobacterium bovis following Neonatal Vaccination with Bacillus Calmette-Guerin Danish: Significant Protection against Infection at 12, but Not 24, Months [PDF]
, 2012 Vaccination of neonatal calves with Mycobacterium bovis bacillus Calmette-Guerin (BCG) induces a significant degree of protection against bovine tuberculosis, caused by infection with virulent M. bovis.
McAulay, M. +6 more
core +1 more source
Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer. [PDF]
PLoS Neglected Tropical Diseases, 2015 Buruli ulcer, an emerging tropical disease caused by Mycobacterium ulcerans (MU), is characterized by disfiguring skin necrosis and high morbidity. Relatively little is understood about the mode of transmission, pathogenesis, or host immune responses to ...
Bryan E Hart, Laura P Hale, Sunhee Lee
doaj +1 more source
The uraA locus and homologous recombination in Mycobacterium bovis BCG [PDF]
Journal of Bacteriology, 1993 Molecular genetic manipulation of mycobacteria would benefit from the isolation of mycobacterial genes that could serve both as genetic markers and as sequences used to target homologous integration of recombinant DNA into the genome. We isolated the Mycobacterium bovis BCG gene encoding orotidine-5'-monophosphate decarboxylase (OMP-DCase) by ...
A, Aldovini, R N, Husson, R A, Young
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Recombinant Mycobacterium bovis BCG as an HIV Vaccine Vector [PDF]
Current HIV Research, 2010 HIV-1 has resulted in a devastating AIDS pandemic. An effective HIV/AIDS vaccine that can be used to either, prevent HIV infection, control infection or prevent progression of the disease to AIDS is needed. In this review we discuss the use of Mycobacterium bovis BCG, the tuberculosis vaccine, as a vaccine vector for an HIV vaccine.
Rosamund, Chapman +4 more
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BCG vaccination induces different cytokine profiles following infant BCG vaccination in the UK and Malawi [PDF]
, 2011 BACKGROUND: BCG vaccination of infants is thought to provide good protection in all settings. This study investigated whether Malawian infants made weaker responses across a cytokine panel after BCG vaccination, compared with UK infants.METHODS: Diluted ...
Hazel M. Dockrell +62 more
core +1 more source
Use of a Bacteriophage Lysin to Control Axillary Malodor
JEADV Clinical Practice, EarlyView.ABSTRACT Background Axillary malodor is primarily caused by bacteria, particularly Staphylococcus hominis, which metabolize apocrine secretions into volatile compounds. Traditional deodorants contain antiseptics that can disrupt the skin microbiome and cause irritation. Alternative methods of odor control are being sought but so far without success. We
Maurice A. M. van Steensel +3 more
wiley +1 more source
Journal of Immunology Research, 2015 Tuberculosis remains an enormous global burden, despite wide vaccination coverage with the Bacillus Calmette-Guérin (BCG), the only vaccine available against this disease, indicating that BCG-driven immunity is insufficient to protect the human ...
Piotr Szpakowski +9 more
doaj +1 more source
Vaccination with a BCG strain overexpressing Ag85B protects cattle against Mycobacterium bovis challenge. [PDF]
PLoS ONE, 2012 Mycobacterium bovis is the causative agent of tuberculosis in cattle but also infects other animals, including humans. Previous studies in cattle have demonstrated that the protection induced by BCG is not complete.
Caroline Rizzi +13 more
doaj +1 more source