Results 61 to 70 of about 12,446 (175)

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

‘BJUI Clinical Dilemma’: Recurrent high‐grade non‐muscle‐invasive bladder cancer in 2026

BJU International, Volume 138, Issue 1, Page 14-21, July 2026.
Vignesh T. Packiam, Peter C. Black, James W. F. Catto, Saum Ghodoussipour, Max Kates, Ashish M. Kamat, Yair Lotan, Michael A. O’Donnell, Jeremy Y. C. Teoh, George N. Thalmann, Stephen B. Williams   +10 more
wiley   +1 more source

Helminths as architects of trained tolerance: implications for human health

Clinical &Translational Immunology, Volume 15, Issue 3, 2026.
Abstract Helminths infect nearly 2 billion people worldwide and are a major cause of chronic morbidity in low‐resource regions. Unlike bacterial and viral pathogens that elicit protective memory, helminths actively remodel host immunity to enable their years‐long persistence and reinfection.
Quinn Moroz, Jorge Lucas Nascimento Souza, Neima Briggs   +2 more
wiley   +1 more source

Host Genus and Habitat Use Shape the Distribution of Batrachochytrium dendrobatidis Lineages in a Hyper‐Diverse Tropical Amphibian Community

Ecology and Evolution, Volume 16, Issue 3, March 2026.
Anthropogenic change has facilitated the spread of the amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd) in Brazil's Atlantic Forest, where two Bd lineages (Bd‐GPL and Bd‐Brazil) co‐occur. We successfully genotyped 252 Bd‐positive samples from a diverse amphibian assemblage spanning aquatic and terrestrial habitats and found that Bd lineage ...
Shannon Buttimer, Wesley J. Neely, Jack M. Boyette, Carolina Lambertini, Renato Martins, Karen A. Paniagua Torres, David Rodriguez, C. Guilherme Becker   +7 more
wiley   +1 more source

Stable expression of Leptospira interrogans antigens in auxotrophic Mycobacterium bovis BCG

Biological Research, 2010
Mycobacterium bovis BCG has been proposed as an effective live vector for multivalent vaccines. The development of mycobacterial genetic systems to express foreign antigens and the adjuvanticity of BCG are the basis for the potential use of this ...
FABIANA K SEIXAS, SIBELE BORSUK, MICHEL Q FAGUNDES, DAIANE D HARTWIG, ÉVERTON F. DA SILVA, GUSTAVO M CERQUEIRA, ODIR A DELLAGOSTIN   +6 more
doaj  

Vaccination and transfusion safety at the time of expanding use of live attenuated vaccines

Vox Sanguinis, Volume 121, Issue 7, Page 923-926, July 2026.
Pierre Tiberghien, Pierre Gallian, Virginie de La Taille, Caroline Bacquet, Syria Laperche   +4 more
wiley   +1 more source

The Current Landscape and Future Prospects of Vaccine Manufacturing in Africa: Challenges, Innovations, and Opportunities: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Africa has significant challenges in meeting its vaccination needs, including inadequate manufacturing capacity, infrastructure deficiencies, a scarcity of experienced personnel, regulatory hurdles, restricted access to technology and intellectual property.
Courage Chandipwisa, Agness Shimilimo, Olivier Uwishema, Helen Onyeaka   +3 more
wiley   +1 more source

Recombinant protein Ag85B-Rv2660c-MPT70 promotes quality of BCG-induced immune response against Mycobacterium tuberculosis H37Ra

Frontiers in Immunology
IntroductionBacillus Calmette-Guérin (BCG), the only licensed vaccine against Mycobacterium tuberculosis (Mtb) infection, has been extensively used worldwide for over 100 years, but the epidemic of tuberculosis (TB) remains a major challenge to human ...
Jiangshan Ouyang, Shaohua Guo, Zhiming Hu, Ting Cao, Jun Mou, Xinxia Gu, Chunxu Huang, Jie Liu, Jie Liu   +8 more
doaj   +1 more source

Immunogenicity and protective efficacy of a multi-antigenic adenovirus-based vaccine candidate against Mycobacterium tuberculosis

Frontiers in Microbiology
IntroductionThe inadequate efficacy of the Bacillus Calmette–Guérin (BCG) vaccine against adult pulmonary tuberculosis (TB) necessitates the development of new and effective vaccines. Human adenovirus serotype 5 (Ad5), which induces T-cell response, is a
Jin-Seung Yun, Jin-Seung Yun, Eunkyung Shin, Young-Ran Lee, Jung-Ah Lee, Hyeokjin Lee, Jong-Seok Kim, Sung Jae Shin, Sang-Jun Ha, Sang-Won Lee, Dokeun Kim, Jung-Sik Yoo, Hye-Sook Jeong   +12 more
doaj   +1 more source

Efficacy and immunogenicity of rKVAC85B in a BCG prime-boost regimen against H37Rv and HN878 Mycobacterium tuberculosis strains.

PLoS ONE
Mycobacterium tuberculosis infection accounted for 1.3 million deaths worldwide in 2022. Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB); however, it has limited protective efficacy in adults.
Eunkyung Shin, Jin-Seung Yun, Young-Ran Lee, Hye-Ran Cha, Soo-Min Kim, Sung-Jae Shin, Sang-Won Lee, Gyung Tae Chung, Dokeun Kim, Jung Sik Yoo, Jong-Seok Kim, Hye-Sook Jeong   +11 more
doaj   +1 more source