Results 61 to 70 of about 332,084 (209)

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 9, Page 913-932, November 2026.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

The tuberculosis vaccine candidate Bacillus Calmette-Guérin ΔureC::hly coexpressing human interleukin-7 or -18 enhances antigen-specific T cell responses in mice. [PDF]

PLoS ONE, 2013
Bacillus Calmette-Guérin (BCG), the only approved tuberculosis vaccine, provides only limited protection. Previously, we generated a recombinant derivative (BCG ΔureC::hly), which secretes the pore-forming toxin listeriolysin O (LLO) of Listeria ...
Martin Rao, Alexis Vogelzang, Peggy Kaiser, Stefanie Schuerer, Stefan H E Kaufmann, Martin Gengenbacher   +5 more
doaj   +1 more source

Trained Immunity in Childhood Vaccination

Acta Paediatrica, Volume 115, Issue 11, Page 2402-2413, November 2026.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining. [PDF]

, 2010
BACKGROUND: The vaccine efficacy reported following Mycobacterium bovis Bacillus Calmette Guerin (BCG) administration to UK adolescents is 77% and defining the cellular immune response in this group can inform us as to the nature of effective immunity ...
Natalie ER Beveridge, Rose Blitz, Steven G Smith, Blitz, R, Dockrell Hazel M, Smith, SG, Worth Andrew, Hazel M Dockrell, Smith, Steven G, McShane Helen, Maeve K Lalor, Gorak-Stolinska, Patricia, Helen McShane, Lalor, MK, Andrew Worth, Beveridge, NE, Blitz, Rose, Worth, A, Beveridge Natalie ER, Smith Steven G, Lalor Maeve K, Worth, Andrew, Gorak-Stolinska, P, Dockrell, HM, Gorak-Stolinska Patricia, Lalor, Maeve K, Dockrell, Hazel M, Beveridge, Natalie ER, Patricia Gorak-Stolinska, McShane, Helen, Blitz Rose   +30 more
core   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, Volume 38, Issue 56, 8 October 2026.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Comparison of two BCG adjuvants in enhancing the immunogenicity of a DNA vaccine encoding the Toxoplasma gondii ROP2 gene in BALB/c mice

The Microbe
The lack of a definitive treatment against toxoplasmosis and its high prevalence encouraged us to seek ways to expand DNA vaccines. The rhoptry protein 2 (ROP2) of Toxoplasma gondii is one of the most important antigens expressed in all three stages of ...
Hamed Yousefi, Fatemeh Ghaffarifar, Masoud Foroutan, Hélder Cortes, Kamy Hosseinian Khosroshahi   +4 more
doaj   +1 more source

rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector. [PDF]

PLoS ONE, 2008
BACKGROUND: BCG vaccination, combined with adenoviral-delivered boosts, represents a reasonable strategy to augment, broaden and prolong immune protection against tuberculosis (TB).
Isabelle Magalhaes, Donata R Sizemore, Raija K Ahmed, Stefanie Mueller, Lena Wehlin, Charles Scanga, Frank Weichold, Giulia Schirru, Maria Grazia Pau, Jaap Goudsmit, Sharon Kühlmann-Berenzon, Mats Spångberg, Jan Andersson, Hans Gaines, Rigmor Thorstensson, Yasir A W Skeiky, Jerry Sadoff, Markus Maeurer   +17 more
doaj   +1 more source

BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 and Andes orthohantavirus

Vaccines, 2022
Background:Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is a live attenuated vaccine mainly administered to newborns and used for over 100 years to prevent the disease caused by Mycobacterium tuberculosis (M. tb).
Jorge A. Soto, Fabián E. Díaz, Angello Retamal-Díaz, Nicolás M. S. Gálvez, Felipe Melo-González, Alejandro Piña-Iturbe, Mario A. Ramírez, Karen Bohmwald, Pablo A. González, Susan M. Bueno, Alexis M. Kalergis   +10 more
doaj   +1 more source

Thirty years of recombinant BCG: new trends for a centenary vaccine

Expert Review of Vaccines, 2021
Introduction: Global perception of the potential for Bacille Calmette-Guérin (BCG), and consequently recombinant BCG (rBCG), in a variety of prophylactic and therapeutic applications has been increasing. A century of information on BCG, and three decades of experience with rBCG, has generated solid knowledge in this field. Area covered: Here, we review
Lazaro M Marques-Neto, Zuzanna Piwowarska, Alex I. Kanno, Luana Moraes, Monalisa M Trentini, Dunia Rodriguez, Jose L. S. C. Silva, Luciana C. C. Leite   +7 more
openaire   +2 more sources

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source