Results 61 to 70 of about 23,766 (215)

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

Cell Proliferation, EarlyView.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song, Yujie Jiang, Yu Zhang, Danyi Ao, Chunjun Ye, Xiya Huang, Yingqiong Zhou, Hanle Yang, Ruolan Xia, Jiayuan Ai, Dandan Wan, Aiping Tong, Yuquan Wei, Xuemei He, Aqu Alu, Xiawei Wei   +15 more
wiley   +1 more source

A century of BCG vaccination: Immune mechanisms, animal models, non-traditional routes and implications for COVID-19

Frontiers in Immunology, 2022
Bacillus Calmette-Guerin (BCG) has been used as a vaccine against tuberculosis since 1921 and remains the only currently approved vaccine for this infection.
Shivani Singh, Shivani Singh, Shivani Singh, Noemi Alejandra Saavedra-Avila, Sangeeta Tiwari, Steven A. Porcelli, Steven A. Porcelli   +6 more
doaj   +1 more source

Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636 [PDF]

, 2008
The identification of potential new anti-tubercular cemotherapeutics is paramount due to the recent emergence of extensively drug-resistant strains of Mycobacterium tuberculosis (XDR-TB).Libraries of NAS-21 and NAS-91 analogues were synthesized and ...
Besra, Gurdyal S, Bhowruth, Veemal, Brown, Alistair K.   +2 more
core   +2 more sources

Auxotrophic Mycobacterium bovis BCG: Updates and Perspectives

Vaccines, 2022
Mycobacterium bovis BCG has been used for a century as the only licensed vaccine against tuberculosis. Owing to its strong adjuvant properties, BCG has also been employed as an oncological immunotherapeutic as well as a live vaccine vector against other ...
Odir Antônio Dellagostin, Sibele Borsuk, Thaís Larré Oliveira, Fabiana Kömmling Seixas   +3 more
doaj   +1 more source

A novel method for monitoring Mycobacterium bovis BCG trafficking with recombinant BCG expressing green fluorescent protein [PDF]

Clinical Diagnostic Laboratory Immunology, 1996
To better understand intracellular and extracellular trafficking of Mycobacterium bovis bacillus Calmette-Guérin (BCG) when used as an intravesical agent in the treatment of transitional cell carcinoma (TCC) of the bladder, recombinant BCG (rBCG) expressing the jellyfish green fluorescent protein (GFP) was created.
Y, Luo, A, Szilvasi, X, Chen, W C, DeWolf, M A, O'Donnell   +4 more
openaire   +2 more sources

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, Volume 46, Issue 3, Page 672-712, May 2026.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis [PDF]

Scientific Reports, 2017
AbstractIn order to develop an improved BCG vaccine against tuberculosis we have taken advantage of the adjuvant properties of a non-toxic derivative of Escherichia coli heat labile enterotoxin (LT), LTAK63. We have constructed rBCG strains expressing LTAK63 at different expression levels.
Nascimento, Ivan, Rodriguez, Dunia, Santos, C.C., Amaral, E.P., Rofatto, H.K., Junqueira-Kipnis, A.P., Gonçalves, E.D.C., d'Império-Lima, M.R., Hirata, M.H., Silva, C.L., Winter, Nathalie, Gicquel, Brigitte, Mills, K.H.G., Pizza, Mariagrazia, Rappuoli, Rino, Leite, L.C.C.   +15 more
openaire   +7 more sources

The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination [PDF]

, 2018
Immunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T cells play a central role in all adaptive immune responses.
Gray, Joshua I., Macleod, Megan K.L., Westerhof, Lotus   +2 more
core   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

The tuberculosis vaccine candidate Bacillus Calmette-Guérin ΔureC::hly coexpressing human interleukin-7 or -18 enhances antigen-specific T cell responses in mice. [PDF]

PLoS ONE, 2013
Bacillus Calmette-Guérin (BCG), the only approved tuberculosis vaccine, provides only limited protection. Previously, we generated a recombinant derivative (BCG ΔureC::hly), which secretes the pore-forming toxin listeriolysin O (LLO) of Listeria ...
Martin Rao, Alexis Vogelzang, Peggy Kaiser, Stefanie Schuerer, Stefan H E Kaufmann, Martin Gengenbacher   +5 more
doaj   +1 more source