Results 71 to 80 of about 23,766 (215)

Type I interferons in tuberculosis: Foe and occasionally friend [PDF]

, 2018
Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection.
Mayer-Barber, K, Moreira-Teixeira, L, O'Garra, A, Sher, A   +3 more
core   +1 more source

Biopharmaceuticals for Cancer Treatment: An Update

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer is one of the most debilitating diseases, causing profound physical and psychological impacts on patients. The global number of cancer patients has been steadily rising over the last few decades. The development of effective cancer therapies remains the primary focus in life science research, requiring a precise understanding of ...
Anupom Deb Nath, Yousuf Alam, Afsana Mustak Mim, Maksuda Akter, Mohammad Abbas Gani, Khondaker Muhammad Khairul Alam, Md. Nur Alam   +6 more
wiley   +1 more source

Comparison of two BCG adjuvants in enhancing the immunogenicity of a DNA vaccine encoding the Toxoplasma gondii ROP2 gene in BALB/c mice

The Microbe
The lack of a definitive treatment against toxoplasmosis and its high prevalence encouraged us to seek ways to expand DNA vaccines. The rhoptry protein 2 (ROP2) of Toxoplasma gondii is one of the most important antigens expressed in all three stages of ...
Hamed Yousefi, Fatemeh Ghaffarifar, Masoud Foroutan, Hélder Cortes, Kamy Hosseinian Khosroshahi   +4 more
doaj   +1 more source

rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector. [PDF]

PLoS ONE, 2008
BACKGROUND: BCG vaccination, combined with adenoviral-delivered boosts, represents a reasonable strategy to augment, broaden and prolong immune protection against tuberculosis (TB).
Isabelle Magalhaes, Donata R Sizemore, Raija K Ahmed, Stefanie Mueller, Lena Wehlin, Charles Scanga, Frank Weichold, Giulia Schirru, Maria Grazia Pau, Jaap Goudsmit, Sharon Kühlmann-Berenzon, Mats Spångberg, Jan Andersson, Hans Gaines, Rigmor Thorstensson, Yasir A W Skeiky, Jerry Sadoff, Markus Maeurer   +17 more
doaj   +1 more source

Bacille Calmette–Guérin (BCG)-associated inflammation and fibrosis: modulation by recombinant BCG expressing interferon-gamma (IFN-γ) [PDF]

Clinical and Experimental Immunology, 2000
SUMMARYImmunization with existing BCG vaccines has failed to confer consistent protection against tuberculosis. One of the ways to improve the efficacy of BCG is by enhancing its ability to induce a type-1 T cell response. However, this approach carries the risk that enhanced immunoreactivity may exacerbate tissue pathology associated with vaccination.
A, Wangoo, I N, Brown, B G, Marshall, H T, Cook, D B, Young, R J, Shaw   +5 more
openaire   +2 more sources

Mycobacterium tuberculosis antigen 85B and ESAT-6 expressed as a recombinant fusion protein in Mycobacterium smegmatis elicits cell-mediated immune response in a murine vaccination model [PDF]

, 2013
This is the post-print version of the final paper published in Molecular Immunology. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting ...
Aagaard, Agger, Andersen, Andersen, Anthony G. Tsolaki, Bennekov, Blokpoel, Brian D. Robertson, Carroll, Crowe, Curcic, Delogu, Delogu, DeMaio, Dietrich, Dye, Dziadek, Ehrt, Fine, Garbe, Gupta, Hanekom, Ida Rosenkrands, Judit Nagy, Laemmli, Langermans, Maher, Masungi, Menozzi, Menozzi, Okkels, Olsen, O’Donnell, Parish, Pethe, Roche, Russell, Sambrook, Sergio Leiva, Temmerman, Triccas, Triccas, Tsolaki, Uday Kishore, van Dissel, van Dissel, Weinrich Olsen, Wiles, Williams   +48 more
core   +1 more source

Bacterial Extracellular Vesicles in Biomedical Research and Clinical Translation

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Bacterial membrane vesicle biomedical applications. ABSTRACT Bacterial Extracellular Vesicles (bEVs) are lipid (single‐ or double‐bilayer) nanostructures secreted by virtually all bacteria that play fundamental roles in intercellular communication and have emerged as powerful, multifunctional tools in biomedicine. Their intrinsic ability to encapsulate
Alejandro Arce‐Rodríguez, Javier De la Peña Noya, José Manuel Borrero‐de Acuña   +2 more
wiley   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 and Andes orthohantavirus

Vaccines, 2022
Background:Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is a live attenuated vaccine mainly administered to newborns and used for over 100 years to prevent the disease caused by Mycobacterium tuberculosis (M. tb).
Jorge A. Soto, Fabián E. Díaz, Angello Retamal-Díaz, Nicolás M. S. Gálvez, Felipe Melo-González, Alejandro Piña-Iturbe, Mario A. Ramírez, Karen Bohmwald, Pablo A. González, Susan M. Bueno, Alexis M. Kalergis   +10 more
doaj   +1 more source

Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memory [PDF]

Frontiers in Immunology, 2014
Bacille Calmette-Guérin (BCG), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine of choice against tuberculosis (TB). Despite its protection against active TB in children, BCG has failed to protect adults against TB infection and active disease development, especially in developing countries where the disease is endemic ...
da Costa, Adeliane Castro, Nogueira, Sarah Veloso, Kipnis, André, Junqueira-Kipnis, Ana Paula   +3 more
openaire   +3 more sources