Results 71 to 80 of about 12,446 (175)

Screening and preclinical assessment of novel Mycobacterium tuberculosis recombinant antigens based tuberculin skin testing

Frontiers in Immunology
IntroductionA new class of Mycobacterium tuberculosis (MTB) antigen-based skin tests was recommended by WHO for the diagnosis of TB infection. However, their performance in some settings remains suboptimal.
Xichao Ou, Xichao Ou, Eryong Liu, Eryong Liu, Faiqa Rashid, Shaojun Pei, Shaojun Pei, Shaojun Pei, Guoqin Zhang, Richard Anthony, Ruida Xing, Ruida Xing, Fei Huang, Fei Huang, Hui Xia, Hui Xia, Yang Zheng, Yang Zheng, Yuanyuan Song, Yuanyuan Song, Yang Zhou, Yang Zhou, Bing Zhao, Bing Zhao, Shengfen Wang, Shengfen Wang, Minggui Lin, Lin Zhou, Lin Zhou, Yanlin Zhao, Yanlin Zhao   +30 more
doaj   +1 more source

Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle.

PLoS ONE, 2015
The incidence of bovine tuberculosis (bTB) in the GB has been increasing since the 1980s. Immunisation, alongside current control measures, has been proposed as a sustainable measure to control bTB. Immunisation with Mycobacterium bovis bacillus Calmette-
Gillian S Dean, Derek Clifford, Adam O Whelan, Elma Z Tchilian, Peter C L Beverley, Francisco J Salguero, Zhou Xing, Hans M Vordermeier, Bernardo Villarreal-Ramos   +8 more
doaj   +1 more source

Novel vaccination strategies based on recombinant Mycobacterium bovis BCG

International Journal of Medical Microbiology, 2003
In this manuscript, we will review the utilization of Mycobacterium bovis Bacille Calmette-Guerin (BCG) as a vaccine against tuberculosis (TB) and as a carrier system for heterologous antigens. BCG is one of the most widely used vaccines. Novel techniques in genome manipulation allow the construction of virulence-attenuated recombinant (r)-BCG strains ...
Guido, Dietrich, Jean-Francois, Viret, Jürgen, Hess   +2 more
openaire   +2 more sources

Boosting BCG with recombinant influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against Mycobacterium tuberculosis infection

PLoS ONE, 2021
The current Mycobacterium bovis BCG vaccine provides inconsistent protection against pulmonary infection with Mycobacterium tuberculosis. Immunity induced by subcutaneous immunization with BCG wanes and does not promote early recruitment of T cell to the
Heni Muflihah, Manuela Flórido, Leon C. W. Lin, Yingju Xia, James A. Triccas, John Stambas, Warwick J. Britton   +6 more
doaj  

Immunogenicity and Protective Efficacy against Murine Tuberculosis of a Prime-Boost Regimen with BCG and a DNA Vaccine Expressing ESAT-6 and Ag85A Fusion Protein

Clinical and Developmental Immunology, 2011
Heterologous prime-boost regimens utilizing BCG as a prime vaccine probably represent the best hope for the development of novel tuberculosis (TB) vaccines.
Jia Lu, Chun Wang, Zhiguang Zhou, Ying Zhang, Tingting Cao, Chunwei Shi, Zhenhua Chen, Lingxia Chen, Changxue Cai, Xionglin Fan   +9 more
doaj   +1 more source

Study on recombinant BCG to prevent infections of intracellular pathogens.

Japanese journal of leprosy, 2000
Studies on recombinant BCG (rBCG) which my group carried out so far were reviewed. Recombinant BCG which secreted alpha antigen-fused foreign antigen was constructed and tested for its ability to induce protective immunity. Thus, rBCG secreting merozoite surface protein 1 (MSP1) of Plasmodium yoelii efficiently protected the infection more than ...
openaire   +2 more sources

Unleashing the power of the BCG vaccine in modulating viral immunity through heterologous protection: A scoping review

Human Vaccines & Immunotherapeutics
The Bacillus Calmette-Guérin (BCG) vaccine, used against tuberculosis for a century, shows promise in protecting against viral infections through trained/innate immunity.
Thales A. Campelo, Natália S. Oliveira, Pedro F. N. Souza, Denis F. G. de-Oliveira, Cristiane C. Frota, Paulo R. Z. Antas   +5 more
doaj   +1 more source

Characterization of the humoral and cellular immunity induced by a recombinant BCG vaccine for the respiratory syncytial virus in healthy adults. [PDF]

Front Immunol, 2023
Pacheco GA, Andrade CA, Gálvez NMS, Vázquez Y, Rodríguez-Guilarte L, Abarca K, González PA, Bueno SM, Kalergis AM.   +8 more
europepmc   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

The Induction of Antigen 85B-Specific CD8⁺ T Cells by Recombinant BCG Protects against Mycobacterial Infection in Mice. [PDF]

Int J Mol Sci, 2023
Komine-Aizawa S, Mizuno S, Kawano A, Hayakawa S, Matsuo K, Honda M.   +5 more
europepmc   +1 more source