Results 71 to 80 of about 332,084 (209)

The Role of EVs in the Aging Hematopoietic System

Aging Cell, Volume 25, Issue 10, October 2026.
Extracellular vesicles from aged bone marrow carry pro‐inflammatory cargo that drives blood stem cell decline, while youthful vesicles restore or maintain stem cell function. Circulating vesicles therefore represent both a readout of hematopoietic aging and a potential therapeutic route.
Esra G. Kosebent, Nathalie Havranek, Karoline Kollmann, Kristina Kirschner, Eszter Doma, Kavya Gupta   +5 more
wiley   +1 more source

The influence of prior exposure to environmental mycobacteria on the IFN-(gamma) response to BCG vaccination in southern England and northern Malaw [PDF]

, 2006
We report a large study of the effect of BCG vaccination on the in vitro 6-day whole blood interferon-gamma (IFN-γ) response to antigens from eight species of mycobacteria among schoolchildren in south-eastern England, where bacille Calmette–Guérin (
Donovan, L, Black, G, Nazareth, B, Sichali, L, Chaguluka, S, Weir, R, Stenson, S, Branson, K, Crampin, A, Dockrell, HM, Stanley, C, Floyd, S, Fine, P   +12 more
core   +4 more sources

Recombinant BCG expressing HIV-1 C GAG : selection of the vaccine gene and construction and evaluation as a vaccine candidate [PDF]

, 2005
Includes bibliographical ...
Thomas, Robin
core   +1 more source

Rapid normal fibroblast‐tumor crosstalk promotes cancer‐associated fibroblast‐like activation and attenuates mitomycin C cytotoxicity in bladder cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Normal bladder fibroblasts rapidly engage in bidirectional crosstalk with bladder cancer cells, acquiring cancer‐associated fibroblast‐like activation features while promoting wound closure, epithelial‐mesenchymal transition‐like cadherin remodeling, and reduced mitomycin C‐induced cytotoxicity.
Jinhui Gao, Cindy Xinyu Ji, Ci Ren, John Hines, Eleanor Stride, Richard T. Bryan, Jennifer L. Rohn   +6 more
wiley   +1 more source

Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memory [PDF]

Frontiers in Immunology, 2014
Bacille Calmette-Guérin (BCG), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine of choice against tuberculosis (TB). Despite its protection against active TB in children, BCG has failed to protect adults against TB infection and active disease development, especially in developing countries where the disease is endemic ...
da Costa, Adeliane Castro, Nogueira, Sarah Veloso, Kipnis, André, Junqueira-Kipnis, Ana Paula   +3 more
openaire   +3 more sources

Identification of Antigens Specific to Non-Tuberculous Mycobacteria: The Mce Family of Proteins as a Target of T Cell Immune Responses [PDF]

, 2011
The lack of an effective TB vaccine hinders current efforts in combating the TB pandemic. One theory as to why BCG is less protective in tropical countries is that exposure to non-tuberculous mycobacteria (NTM) reduces BCG efficacy.
Willem A Hanekom, Anna M Checkley, Wyllie, David H., Hill, Adrian, Thomas J Scriba, Hill Adrian V. S., Hanekom, Willem A., Thomas J. Scriba, McShane Helen, Hanekom Helen Mcshane, Willem A, Golubchik Tanya, Hanekom Willem A., Willem A. Hanekom, Hill, AV, Golubchik, Tanya, Anna M. Checkley, Helen McShane, Wyllie David H., Wyllie, DH, David H Wyllie, David H. Wyllie, Hanekom, WA, Scriba, Thomas J., Checkley Anna M., Scriba Thomas J., Hill, Adrian V. S., Scriba, TJ, Checkley, Anna M., Checkley, AM, Golubchik, T, Wyllie, David, Adrian V S Hill, Adrian V. S. Hill, Tanya Golubchik, McShane, H, McShane, Helen   +36 more
core   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, Volume 179, Issue 1, Page 54-71, September 2026.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Recombinant BCG as a vaccine vehicle to protect against tuberculosis [PDF]

Bioengineered Bugs, 2010
Mycobacterium bovis Bacille Calmette Guérin (BCG) was first administered to humans in 1921 and has subsequently been delivered to an estimated 3 billion individuals, with a low incidence of serious complications. The vaccine is immunogenic and is stable and cheap to produce.
openaire   +2 more sources

The influence of BCG vaccine strain on mycobacteria-specific and non-specific immune responses in a prospective cohort of infants in Uganda. [PDF]

, 2012
BACKGROUND: Globally, BCG vaccination varies in efficacy and has some non-specific protective effects. Previous studies comparing BCG strains have been small-scale, with few or no immunological outcomes and have compared TB-specific responses only.
Webb, Emily L, Nampijja, Margaret, Anderson, Elizabeth J., Anderson, Elizabeth J, Mawa, Patrice A, Lyadda, Nancy, Elliott, Alison M, Webb, Emily L., Elliott, Alison M., Mawa, Patrice A., Kizza, Moses   +10 more
core   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source