Results 91 to 100 of about 332,084 (209)

Guideline for the Diagnosis and Management of Heritable IFNAR1 Deficiency in Oceania

Journal of Paediatrics and Child Health, Volume 62, Issue 7, Page 1113-1120, July 2026.
ABSTRACT Autosomal recessive interferon alpha and beta receptor subunit 1 (IFNAR1) deficiency is a rare and heritable inborn error of immunity (IEI) predisposing individuals to severe and life‐threatening viral infections. It is more common in people of Western Polynesian ancestry, with estimates of around one in six thousand live births affected, due ...
Cecilia Verryt, Paul Gray, Peter McNaughton, Jane Peake, Melanie Wong, George Aho, Emma Best, Maia Brewerton, Flora Lutui, Litara Esera Tulifau, Rebecca Qin, Satupa‘itea Viali, Petine White, Andrew Wood, See‐Tarn Woon, Theresa Cole, Alberto Pinzon Charry, Kuang‐Chih Hsiao   +17 more
wiley   +1 more source

Optimisation of the mycobacterial replicon of an E. coli-mycobacterial shuttle vector [PDF]

, 2007
Includes bibliographical references (leaves 89-95).This study aimed to investigate whether the mycobacterial replicon may also play a role. The common mycobacterial replicon in episomal E.
Griffin, Sarah
core   +1 more source

Recombinant protein Ag85B-Rv2660c-MPT70 promotes quality of BCG-induced immune response against Mycobacterium tuberculosis H37Ra

Frontiers in Immunology
IntroductionBacillus Calmette-Guérin (BCG), the only licensed vaccine against Mycobacterium tuberculosis (Mtb) infection, has been extensively used worldwide for over 100 years, but the epidemic of tuberculosis (TB) remains a major challenge to human ...
Jiangshan Ouyang, Shaohua Guo, Zhiming Hu, Ting Cao, Jun Mou, Xinxia Gu, Chunxu Huang, Jie Liu, Jie Liu   +8 more
doaj   +1 more source

Immunogenicity and protective efficacy of a multi-antigenic adenovirus-based vaccine candidate against Mycobacterium tuberculosis

Frontiers in Microbiology
IntroductionThe inadequate efficacy of the Bacillus Calmette–Guérin (BCG) vaccine against adult pulmonary tuberculosis (TB) necessitates the development of new and effective vaccines. Human adenovirus serotype 5 (Ad5), which induces T-cell response, is a
Jin-Seung Yun, Jin-Seung Yun, Eunkyung Shin, Young-Ran Lee, Jung-Ah Lee, Hyeokjin Lee, Jong-Seok Kim, Sung Jae Shin, Sang-Jun Ha, Sang-Won Lee, Dokeun Kim, Jung-Sik Yoo, Hye-Sook Jeong   +12 more
doaj   +1 more source

Efficacy and immunogenicity of rKVAC85B in a BCG prime-boost regimen against H37Rv and HN878 Mycobacterium tuberculosis strains.

PLoS ONE
Mycobacterium tuberculosis infection accounted for 1.3 million deaths worldwide in 2022. Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB); however, it has limited protective efficacy in adults.
Eunkyung Shin, Jin-Seung Yun, Young-Ran Lee, Hye-Ran Cha, Soo-Min Kim, Sung-Jae Shin, Sang-Won Lee, Gyung Tae Chung, Dokeun Kim, Jung Sik Yoo, Jong-Seok Kim, Hye-Sook Jeong   +11 more
doaj   +1 more source

Screening and preclinical assessment of novel Mycobacterium tuberculosis recombinant antigens based tuberculin skin testing

Frontiers in Immunology
IntroductionA new class of Mycobacterium tuberculosis (MTB) antigen-based skin tests was recommended by WHO for the diagnosis of TB infection. However, their performance in some settings remains suboptimal.
Xichao Ou, Xichao Ou, Eryong Liu, Eryong Liu, Faiqa Rashid, Shaojun Pei, Shaojun Pei, Shaojun Pei, Guoqin Zhang, Richard Anthony, Ruida Xing, Ruida Xing, Fei Huang, Fei Huang, Hui Xia, Hui Xia, Yang Zheng, Yang Zheng, Yuanyuan Song, Yuanyuan Song, Yang Zhou, Yang Zhou, Bing Zhao, Bing Zhao, Shengfen Wang, Shengfen Wang, Minggui Lin, Lin Zhou, Lin Zhou, Yanlin Zhao, Yanlin Zhao   +30 more
doaj   +1 more source

The Effect of Stress, BCG Vaccination,and Combination of Stress-BCG Vaccination to The Ability of Macrophage to Bind with CD4+ T Cells in BALB/c Mice [PDF]

, 2006
The Effect of Stress, BCG Vaccination,and Combination of Stress-BCG Vaccination to The Ability of Macrophage to Bind with CD4+ T Cells in BALB/c Mice Rahajeng N. Tunjung*, Dwi Pudjonarko** Background.
Tunjung, Rahajeng_N.
core   +1 more source

Mycobacterium tuberculosis antigen 85B and ESAT-6 expressed as a recombinant fusion protein in Mycobacterium smegmatis elicits cell-mediated immune response in a murine vaccination model [PDF]

, 2013
This is the post-print version of the final paper published in Molecular Immunology. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting ...
Kishore, U, Leiva, S, Robertson, BD, Rosenkrands, I, Nagy, J, Tsolaki, AG   +5 more
core   +1 more source

Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle.

PLoS ONE, 2015
The incidence of bovine tuberculosis (bTB) in the GB has been increasing since the 1980s. Immunisation, alongside current control measures, has been proposed as a sustainable measure to control bTB. Immunisation with Mycobacterium bovis bacillus Calmette-
Gillian S Dean, Derek Clifford, Adam O Whelan, Elma Z Tchilian, Peter C L Beverley, Francisco J Salguero, Zhou Xing, Hans M Vordermeier, Bernardo Villarreal-Ramos   +8 more
doaj   +1 more source

The response of human dendritic cells to recombinant adenovirus, recombinant Mycobacterium bovis Bacillus Calmette Guerin and biolistic methods of antigen delivery: different induction of contact-dependant and soluble signals.

, 2001
Dendritic cells (DCs) are the most potent antigen presenting cells for inducing T-cell immune responses. The ability to grow human DCs from monocyte precursors provides an abundant source of these cells, which can be modified in vitro to present antigens.
Smith, SG, Patel, PM, Steven G Smith, Peter J Selby, Jackson, AM, Poulam M Patel, Andrew M Jackson, Selby, PJ   +7 more
core   +1 more source