Clinical &Translational Immunology, Volume 15, Issue 1, 2026.In this study, we analysed the immune responses of blood‐derived monocyte macrophages and iPSC‐derived macrophages following BCG/HKMT infection. We found that iPSC‐derived macrophages displayed a markedly stronger activation profile, including faster migration, increased reactive oxygen species production, elevated apoptosis marker expression and ...
Daniela Paasch +17 more
wiley +1 more source
Stable expression of Leptospira interrogans antigens in auxotrophic Mycobacterium bovis BCG
Biological Research, 2010 Mycobacterium bovis BCG has been proposed as an effective live vector for multivalent vaccines. The development of mycobacterial genetic systems to express foreign antigens and the adjuvanticity of BCG are the basis for the potential use of this ...
FABIANA K SEIXAS +6 more
doaj
Novel polyhydroxyalkanoate beads for use as a vaccine against tuberculosis : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Microbiology at Massey University, Manawatū, New Zealand [PDF]
, 2017 Tuberculosis was in 1993 declared as a re-emerging disease by the World Health Organization. The only vaccine currently available, BCG, an attenuated strain of Mycobacterium bovis, does not protect adults against the pulmonary disease, which is the ...
Rubio Reyes, Patricia
core
Immunization with antigenic extracts of Leishmania associated with Montanide ISA 763 adjuvant induces partial protection in BALB/c mice against Leishmania (Leishmania) amazonensis infection [PDF]
, 2014 Background/Purpose: A proper adjuvant has a relevant role in vaccine formulations to generate an effective immune response. In this study, total Leishmania antigen (TLA) formulated with Montanide ISA 763 or R848 as adjuvants were evaluated as a first ...
Cargnelutti, Diego Esteban +6 more
core +1 more source
Immune Modulation by Plasmodium yoelii: Insights From Lethal and Non‐Lethal Strains
Parasite Immunology, Volume 48, Issue 1, January 2026.ABSTRACT Malaria pathogenesis is driven by intricate host–parasite interactions that determine immune balance and clinical outcome. The Plasmodium yoelii model, particularly its lethal (17XL) and non‐lethal (17XNL) strains, provides a robust framework to investigate these dynamics.
Sharoen Yu Ming Lim
wiley +1 more source
Frontiers in ImmunologyIntroductionBacillus Calmette-Guérin (BCG), the only licensed vaccine against Mycobacterium tuberculosis (Mtb) infection, has been extensively used worldwide for over 100 years, but the epidemic of tuberculosis (TB) remains a major challenge to human ...
Jiangshan Ouyang +8 more
doaj +1 more source
Expression and Purification of the Recombinant Cytochrome P450 CYP141 Protein of Mycobacterium Tuberculosis as a Diagnostic Tool and Vaccine Production [PDF]
, 2015 Background: Tuberculosis (TB) is regarded as a health problem worldwide, particularly in developing countries. Mycobacterium tuberculosis (M. tuberculosis) is the cause of this disease.
Abdian, Narges. +7 more
core +3 more sources
Anticipating Knowledge Applicability in Open Science Through Recycling, Mimicking, and Shortcutting
R&D Management, Volume 56, Issue 1, Page 71-87, January 2026.ABSTRACT Open science literature scrutinizes how organizations provide access to knowledge. Yet, much less is known about how organizations pursuing open science for societal impact anticipate knowledge applicability—that shared knowledge is reusable for other organizations and individuals, and enables open social innovation.
Konstantin Hondros +3 more
wiley +1 more source
Frontiers in MicrobiologyIntroductionThe inadequate efficacy of the Bacillus Calmette–Guérin (BCG) vaccine against adult pulmonary tuberculosis (TB) necessitates the development of new and effective vaccines. Human adenovirus serotype 5 (Ad5), which induces T-cell response, is a
Jin-Seung Yun +12 more
doaj +1 more source
PLoS ONEMycobacterium tuberculosis infection accounted for 1.3 million deaths worldwide in 2022. Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB); however, it has limited protective efficacy in adults.
Eunkyung Shin +11 more
doaj +1 more source