Results 31 to 40 of about 2,460 (182)

Evaluation of Lsa46 and Lsa77 Leptospiral Proteins for Their Immunoprotective Activities in Hamster Model of Leptospirosis

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
Leptospirosis is a neglected tropical disease caused by pathogenic Leptospira spp. The lack of an effective vaccine favors the increase of the disease. Currently, surface‐exposed proteins are the main targets for the search of vaccine candidates. In this study, we examined whether the surface Lsa46 and Lsa77 proteins, previously identified as laminin ...
Aline F. Teixeira, Luis G. V. Fernandes, Antonio Souza Filho, Gisele O. Souza, Silvio A. Vasconcellos, Marcos B. Heinemann, Ana L. T. O. Nascimento, Mingtao Zeng   +7 more
wiley   +1 more source

The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens

Journal of Nanobiotechnology
Background Lipid nanoparticles (LNP) are a safe and effective messenger RNA (mRNA) delivery system for vaccine applications, as shown by the COVID-19 mRNA vaccines.
Renata S. Fernandes, Gabriela de Assis Burle-Caldas, Sarah Aparecida Rodrigues Sergio, Ana Flávia Bráz, Nathália Pereira da Silva Leite, Milton Pereira, Juliana de Oliveira Silva, Natália Satchiko Hojo-Souza, Bianca de Oliveira, Ana Paula S. Moura Fernandes, Flávio Guimarães da Fonseca, Ricardo Tostes Gazzinelli, Diego dos Santos Ferreira, Santuza M. Ribeiro Teixeira   +13 more
doaj   +1 more source

Seroprevalence study reveals pertussis underreporting in Brazil and calls for adolescent/young adult boosting: mouse model demonstrates immunity restoration

Frontiers in Immunology
BackgroundPertussis continues to pose a significant threat despite the availability of effective vaccines. The challenge lies in the vulnerability of infants who have not yet completed their vaccination schedule and in adolescents and adults becoming ...
Eliane P. Silva, Monalisa Trentini, Dunia Rodriguez, Alex I. Kanno, Filumena M. S. Gomes, Maria H. Valente, Carlos E. M. Trufen, Lais S. Yamamoto, Arthur D. Januzzi, Priscila S. Cunegundes, Ricardo Palacios, Renan P. Souza, Isaías Raw, Luciana C. C. Leite, Waldely O. Dias   +14 more
doaj   +1 more source

Porcine circovirus 2: Status atual e seus desafios

Pubvet, 2022
Os circovírus suíno (Porcine circovirus - PCV), descritos pela primeira vez na década de 70, são os menores vírus pertencentes à família Circoviridae.
Rosecleer Rodrigues da Silva, Rosecleer Rodrigues da Silva   +1 more
doaj   +1 more source

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source

DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha‐Mangostin

Evidence-Based Complementary and Alternative Medicine, Volume 2016, Issue 1, 2016., 2016
Garcinia mangostana, popularly known as “mangosteen fruit,” originates from Southeast Asia and came to Brazil about 80 years ago where it mainly grows in the states of Pará and Bahia. Although mangosteen or its extracts have been used for ages in Asian folk medicine, data on its potential genotoxicity is missing.
Ronaldo Carvalho-Silva, Alanna Cibelle Fernandes Pereira, Rúbens Prince dos Santos Alves, Temenouga N. Guecheva, João A. P. Henriques, Martin Brendel, Cristina Pungartnik, Fabrício Rios-Santos, Rainer W. Bussmann   +8 more
wiley   +1 more source

Emergence of Candida (Candidozyma) auris in Minas Gerais, Brazil: Genomic Surveillance to Guide Rapid Public Health Responses

Mycoses, Volume 69, Issue 2, February 2026.
ABSTRACT Background Candida (Candidozyma) auris is an emerging yeast that poses a significant global health threat due to its multidrug resistance and ability to cause healthcare‐associated outbreaks. Genomic surveillance is essential for monitoring spread, transmission and antifungal resistance.
Luiz Marcelo Ribeiro Tomé, Dhian Renato Almeida Camargo, Rafael Wesley Bastos, Sara Cândida Ferreira dos Santos, Natália Rocha Guimarães, Sílvia Helena Sousa Pietra Pedroso, Paulo Eduardo de Souza da Silva, Aristóteles Góes‐Neto, Lida Jouca de Assis Figueredo, Gabriella da Côrte Castro, Ana Maria Ribeiro Nunes Rodrigues, Flavia Ribeiro Soares Cruzeiro, Nádia Aparecida Campos Dutra, Josiane Barbosa Piedade Moura, Glauco de Carvalho Pereira, Carmem Dolores Faria, Marta Giovanetti, Felipe Campos de Melo Iani, Luiz Carlos Júnior Alcantara, Talita Émile Ribeiro Adelino   +19 more
wiley   +1 more source

CD8+ T Cell‐Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?

Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
MHC‐restricted CD8+ T cells are important during infection with the intracellular protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. Experimental studies performed in the past 25 years have elucidated a number of features related to the immune response mediated by these T cells, which are important for establishing the ...
Fernando dos Santos Virgilio, Camila Pontes, Mariana Ribeiro Dominguez, Jonatan Ersching, Mauricio Martins Rodrigues, José Ronnie Vasconcelos, Edecio Cunha-Neto   +6 more
wiley   +1 more source

Robust Immune Response and Protection against Lethal Pneumococcal Challenge with a Recombinant BCG-PspA-PdT Prime/Boost Scheme Administered to Neonatal Mice

Vaccines
Pneumococcal diseases are an important public health problem, with high mortality rates in young children. Although conjugated pneumococcal vaccines offer high protection against invasive pneumococcal diseases, this is restricted to vaccine serotypes ...
Monalisa Martins Trentini, Dunia Rodriguez, Alex Issamu Kanno, Cibelly Goulart, Michelle Darrieux, Luciana Cezar de Cerqueira Leite   +5 more
doaj   +1 more source

Avaliação das coberturas vacinais em crianças menores de um ano de idade em Curitiba

Revista de Saúde Pública do Paraná, 2022
O presente trabalho teve como objetivo avaliar as coberturas vacinais de crianças menores de um ano de idade no município de Curitiba no período de 2015 a 2020 a fim de verificar o comportamento deste indicador nas ações de saúde da cidade.
Fernanda Marques Otero, Léia Regina Silva, Tânia Mara Silva   +2 more
doaj   +1 more source