Results 31 to 40 of about 52,004 (230)

Porcine circovirus 2: Status atual e seus desafios

Pubvet, 2022
Os circovírus suíno (Porcine circovirus - PCV), descritos pela primeira vez na década de 70, são os menores vírus pertencentes à família Circoviridae.
Rosecleer Rodrigues da Silva, Rosecleer Rodrigues da Silva   +1 more
doaj   +1 more source

A Bivalent Recombinant Mycobacterium bovis BCG Expressing the S1 Subunit of the Pertussis Toxin Induces a Polyfunctional CD4+ T Cell Immune Response

BioMed Research International, Volume 2019, Issue 1, 2019., 2019
Background. A recombinant BCG strain expressing the genetically detoxified S1 subunit of pertussis toxin 9K/129G (rBCG‐S1PT), previously constructed by our research group, demonstrated the ability to develop high protection in mouse models of pertussis challenge which correlated with the induction of a Th1 immune response pattern.
Alex I. Kanno, Cibelly Goulart, Luciana C. C. Leite, Ana C. Pagliarone, Ivan P. Nascimento, Frederick D. Quinn   +5 more
wiley   +1 more source

Optimization of methods for isolation and purification of outer membrane vesicles (OMVs) from Neisseria lactamica

Applied Microbiology and Biotechnology
Outer membrane vesicles (OMVs) are nanoparticles released by Gram-negative bacteria during growth, mainly under stress conditions. OMV-based vaccines have played an important role in vaccination against Neisseria meningitidis serogroup B (MenB ...
Ronaldo Moraes Preto, Vithória Carolyna Trindade dos Santos, Marcos Vinicius Santos Lordelo, Getúlio Henrique Ferreira Pereira, Luciana Cezar de Cerqueira Leite, Viviane Maimoni Gonçalves, Giovana Cappio Barazzone   +6 more
doaj   +1 more source

Evaluation of Lsa46 and Lsa77 Leptospiral Proteins for Their Immunoprotective Activities in Hamster Model of Leptospirosis

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
Leptospirosis is a neglected tropical disease caused by pathogenic Leptospira spp. The lack of an effective vaccine favors the increase of the disease. Currently, surface‐exposed proteins are the main targets for the search of vaccine candidates. In this study, we examined whether the surface Lsa46 and Lsa77 proteins, previously identified as laminin ...
Aline F. Teixeira, Luis G. V. Fernandes, Antonio Souza Filho, Gisele O. Souza, Silvio A. Vasconcellos, Marcos B. Heinemann, Ana L. T. O. Nascimento, Mingtao Zeng   +7 more
wiley   +1 more source

The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens

Journal of Nanobiotechnology
Background Lipid nanoparticles (LNP) are a safe and effective messenger RNA (mRNA) delivery system for vaccine applications, as shown by the COVID-19 mRNA vaccines.
Renata S. Fernandes, Gabriela de Assis Burle-Caldas, Sarah Aparecida Rodrigues Sergio, Ana Flávia Bráz, Nathália Pereira da Silva Leite, Milton Pereira, Juliana de Oliveira Silva, Natália Satchiko Hojo-Souza, Bianca de Oliveira, Ana Paula S. Moura Fernandes, Flávio Guimarães da Fonseca, Ricardo Tostes Gazzinelli, Diego dos Santos Ferreira, Santuza M. Ribeiro Teixeira   +13 more
doaj   +1 more source

Seroprevalence study reveals pertussis underreporting in Brazil and calls for adolescent/young adult boosting: mouse model demonstrates immunity restoration

Frontiers in Immunology
BackgroundPertussis continues to pose a significant threat despite the availability of effective vaccines. The challenge lies in the vulnerability of infants who have not yet completed their vaccination schedule and in adolescents and adults becoming ...
Eliane P. Silva, Monalisa Trentini, Dunia Rodriguez, Alex I. Kanno, Filumena M. S. Gomes, Maria H. Valente, Carlos E. M. Trufen, Lais S. Yamamoto, Arthur D. Januzzi, Priscila S. Cunegundes, Ricardo Palacios, Renan P. Souza, Isaías Raw, Luciana C. C. Leite, Waldely O. Dias   +14 more
doaj   +1 more source

In vitro Evidence of Human Immune Responsiveness Shows the Improved Potential of a Recombinant BCG Strain for Bladder Cancer Treatment

Frontiers in Immunology, 2019
The live attenuated mycobacterial strain BCG, in use as vaccine against tuberculosis, is considered the gold standard for primary therapy of carcinoma in situ of the bladder.
Dunia Rodriguez, Cibelly Goulart, Ana C. Pagliarone, Eliane P. Silva, Eliane P. Silva, Priscila S. Cunegundes, Priscila S. Cunegundes, Ivan P. Nascimento, Ricardo C. Borra, Waldely O. Dias, Aldo Tagliabue, Diana Boraschi, Luciana C. C. Leite   +12 more
doaj   +1 more source

A diplomacia das vacinas

GV-EXECUTIVO, 2021
A Índia desponta como força global para ajudar a imunizar populações em países em desenvolvimento contra a Covid-19 e tem sido um dos principais fornecedores de insumos para o Brasil.
Guilherme Casarões, Leonardo Ananda Gomes   +1 more
openaire   +1 more source

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source