Results 51 to 60 of about 2,519 (182)

The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability

Microorganisms
Bacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival mechanisms during stress conditions. In regular environmental conditions, the antitoxin blocks the toxin, whereas during imbalanced conditions, the antitoxin ...
Deborah K. Damiano, Bruna O. P. Azevedo, George S. C. Fernandes, Aline F. Teixeira, Viviane M. Gonçalves, Ana L. T. O. Nascimento, Alexandre P. Y. Lopes   +6 more
doaj   +1 more source

CRISPR/Cas9 Approach to Generate an Auxotrophic BCG Strain for Unmarked Expression of LTAK63 Adjuvant: A Tuberculosis Vaccine Candidate

Frontiers in Immunology, 2022
Tuberculosis is one of the deadliest infectious diseases and a huge healthcare burden in many countries. New vaccines, including recombinant BCG-based candidates, are currently under evaluation in clinical trials.
Luana Moraes, Luana Moraes, Monalisa Martins Trentini, Dimitrios Fousteris, Dimitrios Fousteris, Silas Fernandes Eto, Ana Marisa Chudzinski-Tavassi, Ana Marisa Chudzinski-Tavassi, Luciana Cezar de Cerqueira Leite, Alex Issamu Kanno   +9 more
doaj   +1 more source

Recombinant BCG expressing the LTAK63 adjuvant improves a short-term chemotherapy schedule in the control of tuberculosis in mice

Frontiers in Immunology, 2022
Tuberculosis (TB) is one of the deadliest infectious diseases around the world. Prevention is based on the prophylactic use of BCG vaccine, effective in infants but as protection wanes with time, adults are less protected.
Monalisa Martins Trentini, Alex Issamu Kanno, Dunia Rodriguez, Lazaro Moreira Marques-Neto, Silas Fernandes Eto, Silas Fernandes Eto, Ana Marisa Chudzinki-Tavassi, Ana Marisa Chudzinki-Tavassi, Luciana Cezar de Cerqueira Leite   +8 more
doaj   +1 more source

Development and characterization of a multimeric recombinant protein using the spike protein receptor binding domain as an antigen to induce SARS‐CoV‐2 neutralization

Immunity, Inflammation and Disease, Volume 12, Issue 7, July 2024.
We generated a new trimeric recombinant continuously expressed in HEK‐293 cells corresponding to the receptor binding domain and the C‐terminus of S1 protein SARS‐Cov2. It was able to generate neutralizing antibodies and suitable for diagnostic procedures of Covid‐19.
Veronica A. de Lima, João P. S. Nunes, Daniela S. Rosa, Rodrigo Ferreira, Maria L. V. Oliva, Robert Andreata‐Santos, Marcia Duarte‐Barbosa, Luiz M. R. Janini, Juliana T. Maricato, Milena A. Akamatsu, Paulo L. Ho, Sergio Schenkman   +11 more
wiley   +1 more source

Highly Atypical 2025 Influenza A Season in Brazil

Influenza and Other Respiratory Viruses, Volume 20, Issue 4, April 2026.
Tatiana P. Portella, Laís Picinini Freitas, Paola Cristina Resende, Marcelo Ferreira da Costa Gomes, Leonardo S. Bastos   +4 more
wiley   +1 more source

Cuidado com vacinas na perspectiva evolucionária de Rodgers

Revista Eletrônica de Enfermagem, 2019
O estudo objetiva analisar o conceito cuidado com vacinas na perspectiva evolucionária de Rodgers. Refere-se a uma análise do conceito cuidado com vacinas, realizada nas bases de dados National Library of Medicine, Cumulative Index to Nursing and Allied ...
Suzane Gomes de Medeiros, Viviane Euzébia Pereira Santos   +1 more
doaj   +1 more source

Long-Term Protective Immune Responses Induced by rBCG-RBD/rRBD Heterologous Prime/Boost Immunization Strategy: Fusion of RBD-Wuhan with LTB Adjuvant Induces Cross-Reactivity with SARS-CoV-2 Variant Omicron

Vaccines
Background/Objectives: SARS-CoV-2, the causative agent of COVID-19, has been responsible for more than seven million deaths worldwide since its emergence.
Giana Carla Gaboardi, Monalisa Martins Trentini, Alex Issamu Kanno, Luana Moraes, Arthur Daniel Januzzi, Lennon Ramos Pereira, Greicy Brisa Malaquias Dias, Luciano Fernandes Huergo, Sergio C. Oliveira, André Bafica, Luciana Cezar de Cerqueira Leite   +10 more
doaj   +1 more source

Imunização de camundongos com vacina viva avirulenta de Trypanosoma cruzi: V. Ensaio de novos esquemas de vacinação

Revista da Sociedade Brasileira de Medicina Tropical, 1971
Camundongos vacinados com uma, duas ou três vacinas vivas quando infectados apresentam melhor grau de imunização e menor reação inflamatória do que animais vacinados unicamente com uma, duas ou três doses de vacinas fenoladas mortas e igualmente ...
Humberto Menezes
doaj   +1 more source

Vacinas contra a hanseniase

Hansenologia Internationalis: hanseníase e outras doenças infecciosas, 1998
A única vacina contra a hanseníase já aprovada para uso humano é o uso de Mycobacterium bovis BCG, utilizada primariamente contra a tuberculose. Entretanto, a eficácia desta vacina contra a hanseníase é bastante variável na literatura científica. Desta forma, a pesquisa de outras vacinas com resultados mais reprodutíveis permanece.
João Renato Rebello Pinho, Heitor Franco de Andrade Júnior, Ana Clara Guerrini Schenberg   +2 more
openaire   +2 more sources

Caracterização de amostras atenuadas do vírus da Diarréia Viral Bovina (BVDV) tipos 1 e 2 para uso em vacinas Characterization of bovine viral diarrhea virus (BVDV) types 1 and 2 isolates for use in vaccines

Pesquisa Veterinária Brasileira, 2004
Este artigo relata a caracterização de duas amostras citopáticas do vírus da Diarréia Viral Bovina (BVDV-1: IBSP-2; BVDV-2: SV-253) submetidas à atenuação por múltiplas passagens em cultivo celular e exposição à radiação ultravioleta.
Marcelo de Lima, Eduardo Furtado Flores, Rudi Weiblen, Fernanda Silveira Flores Vogel, Sandra Arenhart   +4 more
doaj   +1 more source