Results 101 to 110 of about 441,117 (305)
Endolysosomal pathway activity protects cells from neurotoxic TDP-43
Microbial Cell, 2018 The accumulation of protein aggregates in neurons is a typical pathological hallmark of the motor neuron disease amyotrophic lateral sclerosis (ALS) and of frontotemporal dementia (FTD).
Christine Leibiger +7 more
doaj +1 more source
Molecular Biology of the Cell, 2012 The size and copy number of an organelle depend on an equilibrium of membrane fusion and fission. In vitro reconstitution of yeast vacuole fission and fusion shows that TORC1 selectively stimulates fission but does not change fusion activity.
L. Michaillat, T. Baars, A. Mayer
semanticscholar +1 more source
Advanced Science, EarlyView.To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao +12 more
wiley +1 more source
Propeptide of Aminopeptidase 1 Protein Mediates Aggregation and Vesicle Formation in Cytoplasm-to-Vacuole Targeting Pathway [PDF]
, 2011 Mariana Morales Quinones +2 more
openalex +1 more source
Advanced Science, EarlyView.Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Ziwei Lv +6 more
wiley +1 more source
Growth, Dissolution and Segregation of Genetically Encoded RNA Droplets by Ribozyme Catalysis
Angewandte Chemie, EarlyView.Ribozymes enable sequence‐encoded turnover of RNA droplet material, resulting in transiently active droplets that selectively segregate based on their genotype. This establishes a direct link between genetic information and droplet behavior, marking a step toward programmable, evolvable RNA‐based compartments with life‐like properties.
Franziska Giessler +5 more
wiley +2 more sources
Role of VAMP3 and VAMP7 in the commitment ofYersinia pseudotuberculosisto LC3-associated pathways involving single- or double-membrane vacuoles [PDF]
, 2014 Laure‐Anne Ligeon +8 more
openalex +1 more source
Advanced Science, EarlyView.This study demonstrates multifactorial lifestyle impacts on the pathogenesis and progression of cardiovascular diseases by a nanofluorescence sensor array for detecting four redox species and protein phosphorylation levels. Through cross‐scale fluorescence imaging of rats with different diets, we revealed that compared with single dietary interventions,
Jin Li +9 more
wiley +1 more source
Editorial: Molecular Perspectives for Plant Autophagy Regulation
Frontiers in Plant Science, 2022 Yan Bao +4 more
doaj +1 more source