Results 131 to 140 of about 142,204 (338)
Abstract Disruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to
Leif R. Neitzel+5 more
wiley +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang+7 more
wiley +1 more source
ABSTRACT This study establishes a full‐flow passage numerical model of an LNG submerged pump equipped with two‐stage splitter blades through three‐dimensional modeling. Numerical simulations validated by liquid nitrogen experiments demonstrate that at 1.4 times the design flow rate, the peak efficiency reaches 60.6%, with a maximum head of 194.93 m ...
Songyu Yao+4 more
wiley +1 more source
Expert Perspective: Hematologic Malignancies and Vasculitis
Arthritis &Rheumatology, EarlyView.
Michelle L. Robinette, Hetty E. Carraway
wiley +1 more source
In SOD1 mice, symptomatic spinal microglia and astrocytes show increased autophagy flux with greater dysfunction and SOD1 inclusions in astrocytes. Dysfunction was transient (end stage glia displayed control comparable levels of autophagy parameters). ABSTRACT Amyotrophic lateral sclerosis (ALS) is defined by motor neuron death.
Nirma D. Perera+4 more
wiley +1 more source
Editorial: Molecular Perspectives for Plant Autophagy Regulation
Yan Bao+4 more
doaj +1 more source