Results 131 to 140 of about 142,204 (338)

A novel transgenic reporter of extracellular acidification in zebrafish elucidates skeletal muscle T‐tubule pH regulation

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Disruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to
Leif R. Neitzel   +5 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang   +7 more
wiley   +1 more source

Vacuolating Agent [PDF]

open access: yesBMJ, 1961
D I, MAGRATH, K, RUSSELL, J O, TOBIN
openaire   +2 more sources

Study on the Temporal and Spatial Evolution Mechanism of Rotating Cavitation in the First Stage Impeller of LNG Submersible Pump With Two‐Stage Splitter Blades

open access: yesEnergy Science &Engineering, EarlyView.
ABSTRACT This study establishes a full‐flow passage numerical model of an LNG submerged pump equipped with two‐stage splitter blades through three‐dimensional modeling. Numerical simulations validated by liquid nitrogen experiments demonstrate that at 1.4 times the design flow rate, the peak efficiency reaches 60.6%, with a maximum head of 194.93 m ...
Songyu Yao   +4 more
wiley   +1 more source

Expert Perspective: Hematologic Malignancies and Vasculitis

open access: yes
Arthritis &Rheumatology, EarlyView.
Michelle L. Robinette, Hetty E. Carraway
wiley   +1 more source

Mapping Glial Autophagy Dynamics in an Amyotrophic Lateral Sclerosis Mouse Model Reveals Microglia and Astrocyte Autophagy Dysfunction

open access: yesGlia, EarlyView.
In SOD1 mice, symptomatic spinal microglia and astrocytes show increased autophagy flux with greater dysfunction and SOD1 inclusions in astrocytes. Dysfunction was transient (end stage glia displayed control comparable levels of autophagy parameters). ABSTRACT Amyotrophic lateral sclerosis (ALS) is defined by motor neuron death.
Nirma D. Perera   +4 more
wiley   +1 more source

Editorial: Molecular Perspectives for Plant Autophagy Regulation

open access: yesFrontiers in Plant Science, 2022
Yan Bao   +4 more
doaj   +1 more source

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