, 2022 Lipid metabolism is spatiotemporally regulated within cells, yet intervention into lipid functions at subcellular resolution remains difficult. Here, we report a method that enables site-specific release of sphingolipids and cholesterol inside the ...
Hanaa Hariri (12037844) +4 more
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Hansenula Polymorpha Vac8: A Vacuolar Membrane Protein Required for Vacuole Inheritance and Nucleus-Vacuole Junction Formation [PDF]
, 2020 Saccharomyces cerevisiae Vac8 is a vacuolar membrane protein, which functions in vacuole inheritance and fusion, nucleus-vacuole junctions, autophagy and the cytoplasm-to-vacuole-targeting pathway. Here, we analyzed Vac8 of the yeast Hansenula polymorpha.
Singh, Ritika +4 more
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Strategies for maximizing ATP supply in the microsporidian Encephalitozoon cuniculi: direct binding of mitochondria to the parasitophorous vacuole and clustering of the mitochondrial porin VDAC [PDF]
, 2013 Microsporidia are obligate intracellular parasites with extremely reduced genomes and a dependence on host-derived ATP. The microsporidium Encephalitozoon cuniculi proliferates within a membranous vacuole and we investigated how the ATP supply is ...
Howell, Matthew +4 more
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Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol [PDF]
, 2010 The antifungal antibiotic natamycin belongs to the family of polyene antibiotics. Its antifungal activity arises via a specific interaction with ergosterol in the plasma membrane (te Welscher et al., J. Biol. Chem. 283:6393-6401, 2008).
van Leeuwen, M.R. +12 more
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Reprogramming cells to study vacuolar development [PDF]
, 2013 During vegetative and embryonic developmental transitions, plant cells are massively reorganized to support the activities that will take place during the subsequent developmental phase.
Yuhai Cui +9 more
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Shigella sonnei O-Antigen Inhibits Internalization, Vacuole Escape, and Inflammasome Activation [PDF]
, 2019 Two Shigella species, flexneri and sonnei, cause approximately 90% of bacterial dysentery worldwide. While S. flexneri is the dominant species in low-income countries, S. sonnei causes the majority of infections in middle and high-income countries.
Goddard, Philippa J. +20 more
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Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole [PDF]
, 1998 During each cell cycle, the yeast vacuole ac-tively partitions between mother and daughter cells. This process requires actin, profilin, an unconventional myosin (Myo2p), and Vac8p.
Lois S. Weisman +2 more
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FSM disrupts food vacuole integrity.
, 2022 (A) Electron micrograph demonstrating the normal food vacuolar phenotype of P. falciparum trophozoites (DMSO treated), characterized by a low electron density vacuole containing dense hemozoin crystals.
Naomi Ghebremichael (9578319) +6 more
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Genomic Analysis of Homotypic Vacuole Fusion [PDF]
, 2002 Yeast vacuoles undergo fission and homotypic fusion, yielding one to three vacuoles per cell at steady state. Defects in vacuole fusion result in vacuole fragmentation. We have screened 4828 yeast strains, each with a deletion of a nonessential gene, for
Kato, Masashi +9 more
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Regulation of vacuolar H+-ATPase activity by the Cdc42 effector Ste20 in Saccharomyces cerevisiae [PDF]
, 2012 In the budding yeast Saccharomyces cerevisiae, the Cdc42 effector Ste20 plays a crucial role in the regulation of filamentous growth, a response to nutrient limitation.
Höfken, T, Lin, M, Kane, PM, Li, SC
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