Results 41 to 50 of about 406,286 (313)
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Hepatology, EarlyView., 2022 The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol +22 more
wiley +1 more source
Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates
eLife, 2015 Sumoylation during genotoxic stress regulates the composition of DNA repair complexes. The yeast metalloprotease Wss1 clears chromatin-bound sumoylated proteins.
Maxim Y Balakirev +8 more
doaj +1 more source
TPC1-Type Channels in Physcomitrium patens: Interaction between EF-Hands and Ca2+
Plants, 2022 Two-pore channels (TPCs) are members of the superfamily of ligand-gated and voltage-sensitive ion channels in the membranes of intracellular organelles of eukaryotic cells.
Franko Mérida-Quesada +7 more
doaj +1 more source
Osmosensitivity and Vacuole Biogenesis in Yeast [PDF]
, 1996 A collection of salt-sensitive vacuolar (ssv) Saccharomyces cerevisiae mutants were selected for analysis in an attempt to reveal components of the osmosensing signal transduction pathway.
Harwood, Eleanor Claire
core
Advanced Healthcare Materials, EarlyView.Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni +13 more
wiley +1 more source
THE TONOPLAST TRANSPORT SYSTEMS OF PLANT VACUOLES AND THEIR POTENTIAL APPLICATION IN BIOTECHNOLOGY [PDF]
Biotechnologia Acta, 2013 The pivotal role of plant vacuoles in plant survival was discussed in the review. Particularly, the providing of cellular turgor, accumulation of inorganic osmolytes and nutrients are the primary tasks of these cellular organelles. The main mechanisms of
S. V. Isayenkov
doaj +1 more source
mBio, 2021 Microorganisms typically maintain cellular homeostasis despite facing large fluctuations in their surroundings. Microbes that reside on human mucosal surfaces may experience significant variations in nutrient and ion availability as well as pH.
Philipp Reuter-Weissenberger +2 more
doaj +1 more source
Cloning and characterisation of SSV genes from Saccharomyces Cerevisiae [PDF]
, 1995 In order to investigate the pleiotropic effects exhibited by mutations of S. cerevisiae defective in genes involved in vacuole biogenesis, a number of mutants were chosen for further study.
Hartley, Caroline Anne
core
Advanced Healthcare Materials, EarlyView.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source