Results 31 to 40 of about 406,286 (313)

Arabidopsis myosin XI sub-domains homologous to the yeast myo2p organelle inheritance sub-domain target subcellular structures in plant cells

Frontiers in Plant Science, 2013
Myosin XI motor proteins transport plant organelles on the actin cytoskeleton. The Arabidopsis gene family that encodes myosin XI has 13 members, 12 of which have sub-domains within the tail region that are homologous to well-characterized cargo-binding ...
Amirali eSattarzadeh, Amirali eSattarzadeh, Maureen eHanson, Elmon eSchmelzer   +3 more
doaj   +1 more source

Genome-Wide Identification of Genes Involved in General Acid Stress and Fluoride Toxicity in Saccharomyces cerevisiae

Frontiers in Microbiology, 2020
Hydrofluoric acid elicits cell cycle arrest through a mechanism that has long been presumed to be linked with the high affinity of fluoride to metals.
Nichole R. Johnston, Sunitha Nallur, Patricia B. Gordon, Kathryn D. Smith, Scott A. Strobel, Scott A. Strobel   +5 more
doaj   +1 more source

The Evolution of Leaf Function during Development Is Reflected in Profound Changes in the Metabolic Composition of the Vacuole

Metabolites, 2021
During its development, the leaf undergoes profound metabolic changes to ensure, among other things, its growth. The subcellular metabolome of tomato leaves was studied at four stages of leaf development, with a particular emphasis on the composition of ...
Alice Destailleur, Théo Poucet, Cécile Cabasson, Ana Paula Alonso, Jean-Christophe Cocuron, Romain Larbat, Gilles Vercambre, Sophie Colombié, Pierre Petriacq, Marie Hélène Andrieu, Bertrand Beauvoit, Yves Gibon, Martine Dieuaide-Noubhani   +12 more
doaj   +1 more source

Regulation of vacuolar H+-ATPase activity by the Cdc42 effector Ste20 in Saccharomyces cerevisiae [PDF]

, 2012
In the budding yeast Saccharomyces cerevisiae, the Cdc42 effector Ste20 plays a crucial role in the regulation of filamentous growth, a response to nutrient limitation.
Höfken, T, Lin, M, Kane, PM, Li, SC
core   +1 more source

Salicylic acid: new pathways arising?

Frontiers in Plant Science
While the role of salicylic acid (SA) for plant immunity has been investigated for decades, its function in regulating plant growth and development has only come into focus recently.
Jonas Müller, David Scheuring
doaj   +1 more source

Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol

, 2010
The antifungal antibiotic natamycin belongs to the family of polyene antibiotics. Its antifungal activity arises via a specific interaction with ergosterol in the plasma membrane (te Welscher et al., J. Biol. Chem. 283:6393-6401, 2008).
van Leeuwen, M.R., Dijksterhuis, J., te Welscher, Y.M., de Kruijff, B., Breukink, E.J., Sub Algemeen Scheikunde, Sub Biochemistry of Membranes begr1-6-12, Molecular Microbiology, Sub Molecular Microbiology, Jones, L., Eitzen, G., te Welsher, Y.M., Biochemistry of membranes   +12 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Vac8 spatially confines autophagosome formation at the vacuole [PDF]

, 2019
Autophagy is initiated by the formation of phagophore assembly sites (PAS), the precursors of autophagosomes. In mammals, PAS form throughout the cytosol in specialized subdomains of the endoplasmic reticulum (ER).
Kriegenburg, Franziska, Hollenstein, David M, Licheva, Mariya, Gómez-Sánchez, Rubén, Mari, Muriel, Hollenstein, David M., Torggler, Raffaela, Reggiori, Fulvio, Kraft, Claudine, Ciftci, Akif   +9 more
core   +1 more source