Results 51 to 60 of about 425,388 (212)
Vacuole-targeting fungicidal activity of amphotericin B [PDF]
, 2012 Invasive fungal infections are recognized as major threats to patients with immune depression as well as those with cancer chemotherapy. Amphotericin B (AmB), a classical antifungal agent with a polyene macrolide structure, is widely used for the control
Akira Ogita +5 more
core +1 more source
Advanced Science, EarlyView.TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu +9 more
wiley +1 more source
Advanced Science, EarlyView.Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su +14 more
wiley +1 more source
Advanced Science, EarlyView.The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li +6 more
wiley +1 more source
Die Vacuole eine physikalische Unmöglichkeit
DIE VACUOLE EINE PHYSIKALISCHE UNMÖGLICHKEIT Archiv für Anatomie, Physiologie und wissenschaftliche Medicin (-) Archiv für Anatomie, Physiologie und wissenschaftliche Medicin (-) Die Vacuole eine physikalische Unmöglichkeit (-
Jessen, C.
core +2 more sources
Membrane protein recycling from the vacuole/lysosome membrane
, 2018 The lysosome (or vacuole in yeast) is the central organelle responsible for cellular degradation and nutrient storage. Lysosomes receive cargo from the secretory, endocytic, and autophagy pathways.
Scott D. Emr, Sho W. Suzuki
core +1 more source
Advanced Science, EarlyView.Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang +4 more
wiley +1 more source
Vacuole development in evacuolated oat mesophyll protoplasts
, 1994 Protoplasts were prepared from oat leaf mesophyll cells and subsequently evacuolated by high speed centrifugation through a continuous Percoll gradient.
Newell, Jane Marie, Newell, J. M.
core
The Cyclin-Dependent Kinase Cdk1 Directly Regulates Vacuole Inheritance [PDF]
, 2008 SummaryIn budding yeast, vacuole inheritance is tightly coordinated with the cell cycle. The movement of vacuoles and several other organelles is actin-based and is mediated by interaction between the yeast myosin V motor Myo2 and organelle-specific ...
Weisman, Lois S., Peng, Yutian
core +1 more source
Advanced Science, EarlyView.ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan +10 more
wiley +1 more source