Results 61 to 70 of about 395,932 (267)
SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition
Advanced Science, EarlyView.Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo +14 more
wiley +1 more source
Vacuolar Sequestration Capacity And Long-distance Metal Transport In Plants
Frontiers in Plant Science, 2014 The vacuole is a pivotal organelle functioning in storage of metabolites, mineral nutrients and toxicants in higher plants. Accumulating evidence indicates that in addition to its storage role, the vacuole contributes essentially to long-distance ...
Jiashi ePeng, Jiming eGong
doaj +1 more source
Frontiers in Bioscience, 2012 During the development of malaria parasites within human erythrocytes, the fusion of digestive vesicles gives rise to a large digestive vacuole (DV). This organelle, which is maintained at low pH, processes 60-80 percent of the erythrocyte hemoglobin to provide a pool of amino acids that is crucial for parasite growth and development.
Juliane, Wunderlich +2 more
openaire +2 more sources
Histone Modification Complex JMJ704‐HDA709 Negatively Regulates Salinity Tolerance in Rice
Advanced Science, EarlyView.This study reveals that the rice histone demethylase JMJ704 interacts with HDA709―a H3K9ac deacetylase characterized herein―to form a chromatin‐modifying complex. Under salt stress, OsWRKY72 recruits this complex through interaction with JMJ704 to target loci, repressing the expression of oxidative stress and salt‐responsive genes via removal of ...
Jing Wang +9 more
wiley +1 more source
Advanced Science, EarlyView.Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv +13 more
wiley +1 more source
Glutathione Reductase of Vacuole. Comparison of Glutathione Reductase Activity of Vacuole and Tissue Extract of Red Beet Root (Beta vulgaris L.) [PDF]
Journal of Stress Physiology & Biochemistry, 2016 Glutathione reductase (GR, EC 1.8.1.7) is the enzyme that reduces oxidized glutathione (GSSG) and thus regulates the redox state of glutathione (GSH/GSSG). GR has been studied in most plants.
E.V. Pradedova +2 more
doaj
Chloroplast Protein Degradation in Senescing Leaves: Proteases and Lytic Compartments
Frontiers in Plant Science, 2019 Leaf senescence is characterized by massive degradation of chloroplast proteins, yet the protease(s) involved is(are) not completely known. Increased expression and/or activities of serine, cysteine, aspartic, and metalloproteases were detected in ...
Agustina Buet +3 more
doaj +1 more source
Advanced Science, EarlyView.This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng +14 more
wiley +1 more source
Auxin regulates SNARE-dependent vacuolar morphology restricting cell size
eLife, 2015 The control of cellular growth is central to multicellular patterning. In plants, the encapsulating cell wall literally binds neighbouring cells to each other and limits cellular sliding/migration.
Christian Löfke +3 more
doaj +1 more source