Results 11 to 20 of about 102,643 (210)

SV40 Polyomavirus Activates the Ras-MAPK Signaling Pathway for Vacuolization, Cell Death, and Virus Release

Viruses, 2020
Polyomaviruses are a family of small, non-enveloped DNA viruses that can cause severe disease in immunosuppressed individuals. Studies with SV40, a well-studied model polyomavirus, have revealed the role of host proteins in polyomavirus entry and ...
Nasim Motamedi, Xaver Sewald, Yong Luo, Walther Mothes, Daniel DiMaio   +4 more
doaj   +1 more source

A case of VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) with decreased oxidative stress levels after oral prednisone and tocilizumab treatment

Frontiers in Medicine, 2022
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome has recently been described as an autoinflammatory disease associated with severe adult-onset inflammatory manifestations.
Nagie Tozaki, Chisato Tawada, Hirofumi Niwa, Yoko Mizutani, En Shu, Aki Kawase, Yuki Miwa, Hidenori Ohnishi, Hideo Sasai, Hideo Sasai, Keisuke Miyako, Junichi Hosokawa, Ayaka Kato, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Yohei Shirakami, Masahito Shimizu, Hiroaki Iwata   +17 more
doaj   +1 more source

Runting and Stunting Syndrome Is Associated With Mitochondrial Dysfunction in Sex-Linked Dwarf Chicken

Frontiers in Genetics, 2020
Runting and stunting syndrome (RSS) in chicken are commonly known as “frozen chicken.” The disease is characterized by lower body weight and slow growth and the incidence rate is widely 5%–20% in sex-linked dwarf (SLD) chickens.
Hongmei Li, Hongmei Li, Bowen Hu, Bowen Hu, Qingbin Luo, Qingbin Luo, Shuang Hu, Shuang Hu, Yabiao Luo, Yabiao Luo, Bojing Zhao, Bojing Zhao, Yanmin Gan, Yanmin Gan, Ying Li, Meiqing Shi, Qinghua Nie, Qinghua Nie, Dexiang Zhang, Dexiang Zhang, Xiquan Zhang, Xiquan Zhang   +21 more
doaj   +1 more source

VEXAS Syndrome—Review

Global Medical Genetics, 2023
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a newly defined refractory adult-onset autoinflammatory syndrome caused by somatic mutations in the ubiquitin-like modifier-activating enzyme 1 (UBA1) gene in hematopoietic stem
Zhang Zhang, Dong Dong, Wang Wang
doaj   +1 more source

Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni

Molecules, 2015
Bornyl caffeate (1) was previously isolated by us from Valeriana (V.) wallichii rhizomes and identified as an anti-leishmanial substance. Here, we screened a small compound library of synthesized derivatives 1–30 for activity against schistosomula of ...
Jan Glaser, Uta Schurigt, Brian M. Suzuki, Conor R. Caffrey, Ulrike Holzgrabe   +4 more
doaj   +1 more source

Distinct Roles for KASH Proteins SINE1 and SINE2 in Guard Cell Actin Reorganization, Calcium Oscillations, and Vacuolar Remodeling

Frontiers in Plant Science, 2022
The linker of nucleoskeleton and cytoskeleton (LINC) complex is a protein complex spanning the inner and outer membranes of the nuclear envelope. Outer nuclear membrane KASH proteins interact in the nuclear envelope lumen with inner nuclear membrane SUN ...
Alecia Biel, Morgan Moser, Norman R. Groves, Norman R. Groves, Iris Meier, Iris Meier, Iris Meier   +6 more
doaj   +1 more source

The Vacuolating Autotransporter Toxin (Vat) of Escherichia coli Causes Cell Cytoskeleton Changes and Produces Non-lysosomal Vacuole Formation in Bladder Epithelial Cells

Frontiers in Cellular and Infection Microbiology, 2020
Urinary tract infections (UTIs) affect more than 150 million people, with a cost of over 3.5 billion dollars, each year. Escherichia coli is associated with 70–80% of UTIs. Uropathogenic E.
Juan Manuel Díaz, Charles M. Dozois, Francisco Javier Avelar-González, Eduardo Hernández-Cuellar, Pravil Pokharel, Alfredo Salazar de Santiago, Alma Lilian Guerrero-Barrera   +6 more
doaj   +1 more source

Soil to plant transfer of cadmium☆

Oilseeds and fats, crops and lipids
In soil, cadmium (Cd) is mainly adsorbed onto organic matter and iron hydroxides. Due to the difference in transmembrane electrochemical potential, the hydrated ions (Cd2+) present in the soil solution at the nanomolar level penetrate root cells.
Sterckeman Thibault
doaj   +1 more source

Controlled Activity of the Salmonella Invasion-Associated Injectisome Reveals Its Intracellular Role in the Cytosolic Population

mBio, 2017
The Salmonella invasion-associated type III secretion system (T3SS1) is an essential virulence factor required for entry into nonphagocytic cells and consequent uptake into a Salmonella-containing vacuole (SCV).
Jessica A. Klein, Jesse R. Grenz, James M. Slauch, Leigh A. Knodler   +3 more
doaj   +1 more source

Anti-inflammatory effects of yeast-derived vacuoles on LPS-induced murine macrophage activation

Microbiology Spectrum, 2023
Saccharomyces cerevisiae is a single-celled fungal microorganism. S. cerevisiae-derived vacuoles are closely related to mammalian lysosomes, which play a role in the degradation of macromolecules by various hydrolytic enzymes.
Su-Min Lee, Yang-Hoon Kim, Jiho Min
doaj   +1 more source