Results 11 to 20 of about 225,485 (404)

Intravacuolar persistence in neutrophils facilitates Listeria monocytogenes spread to co-cultured cells [PDF]

mBio
The bacterium Listeria monocytogenes (Lm) causes listeriosis in humans and ruminants. Acute lesions are predominantly infiltrated by polymorphonuclear neutrophils (PMNs), considered to be the efficient bactericidal arm of innate immunity. However, recent
Stefano Bagatella, Camille Monney, Natascha Gross, Véronique Bernier Gosselin, Gertraud Schüpbach-Regula, Andrew Hemphill, Anna Oevermann   +6 more
doaj   +2 more sources

Delayed vacuolation in mammalian cells caused by hypotonicity and ion loss [PDF]

Scientific Reports
Prolonged exposure of mammalian cells to hypotonic environments stimulates the development of sometimes large and numerous vacuoles of unknown origin. Here, we investigate the nature and formation of these vacuoles, which we term LateVacs.
Emily Zook, Yingzhou Edward Pan, Anna Wipplinger, Hubert H. Kerschbaum, Robert J. Clements, Markus Ritter, Tobias Stauber, Michael A. Model   +7 more
doaj   +2 more sources

Clinical heterogeneity in a family with flail arm syndrome and review of hnRNPA1‐related spectrum

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1910-1917, December 2022., 2022
Abstract Objective Flail arm syndrome (FAS) is one of the atypical subtypes of amyotrophic lateral sclerosis (ALS). Mutations in hnRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare genetic cause of ALS. Herein, marked clinical heterogeneity of FAS in a pedigree with a known hnRNPA1 variant was described to raise early ...
Xiaochen Han, Feixia Zhan, Yuxin Yao, Li Cao, Jianguo Liu, Sheng Yao   +5 more
wiley   +1 more source

Notochord vacuoles absorb compressive bone growth during zebrafish spine formation

eLife, 2020
The vertebral column or spine assembles around the notochord rod which contains a core made of large vacuolated cells. Each vacuolated cell possesses a single fluid-filled vacuole, and loss or fragmentation of these vacuoles in zebrafish leads to spine ...
Jennifer Bagwell, James Norman, Kathryn Ellis, B. Peskin, James Hwang, X. Ge, S. Nguyen, S. McMenamin, D. Stainier, M. Bagnat   +9 more
semanticscholar   +1 more source

The guanine nucleotide exchange factor RIC8 regulates conidial germination through Gα proteins in Neurospora crassa. [PDF]

, 2012
Heterotrimeric G protein signaling is essential for normal hyphal growth in the filamentous fungus Neurospora crassa. We have previously demonstrated that the non-receptor guanine nucleotide exchange factor RIC8 acts upstream of the Gα proteins GNA-1 and
Borkovich, Katherine A, Cabrera, Ilva E, Cox, Murray P, Eaton, Carla J, Servin, Jacqueline A, Wright, Sara J   +5 more
core   +15 more sources

Runting and Stunting Syndrome Is Associated With Mitochondrial Dysfunction in Sex-Linked Dwarf Chicken

Frontiers in Genetics, 2020
Runting and stunting syndrome (RSS) in chicken are commonly known as “frozen chicken.” The disease is characterized by lower body weight and slow growth and the incidence rate is widely 5%–20% in sex-linked dwarf (SLD) chickens.
Hongmei Li, Hongmei Li, Bowen Hu, Bowen Hu, Qingbin Luo, Qingbin Luo, Shuang Hu, Shuang Hu, Yabiao Luo, Yabiao Luo, Bojing Zhao, Bojing Zhao, Yanmin Gan, Yanmin Gan, Ying Li, Meiqing Shi, Qinghua Nie, Qinghua Nie, Dexiang Zhang, Dexiang Zhang, Xiquan Zhang, Xiquan Zhang   +21 more
doaj   +1 more source

Distinct Roles for KASH Proteins SINE1 and SINE2 in Guard Cell Actin Reorganization, Calcium Oscillations, and Vacuolar Remodeling

Frontiers in Plant Science, 2022
The linker of nucleoskeleton and cytoskeleton (LINC) complex is a protein complex spanning the inner and outer membranes of the nuclear envelope. Outer nuclear membrane KASH proteins interact in the nuclear envelope lumen with inner nuclear membrane SUN ...
Alecia Biel, Morgan Moser, Norman R. Groves, Norman R. Groves, Iris Meier, Iris Meier, Iris Meier   +6 more
doaj   +1 more source

SV40 Polyomavirus Activates the Ras-MAPK Signaling Pathway for Vacuolization, Cell Death, and Virus Release

Viruses, 2020
Polyomaviruses are a family of small, non-enveloped DNA viruses that can cause severe disease in immunosuppressed individuals. Studies with SV40, a well-studied model polyomavirus, have revealed the role of host proteins in polyomavirus entry and ...
Nasim Motamedi, Xaver Sewald, Yong Luo, Walther Mothes, Daniel DiMaio   +4 more
doaj   +1 more source

Model of inverse bleb growth explains giant vacuole dynamics during cell mechanoadaptation [PDF]

, 2022
Cells can withstand hostile environmental conditions manifest as large mechanical forces such as pressure gradients and/or shear stresses by dynamically changing their shape. Such conditions are realized in the Schlemm's canal of the eye where endothelial cells that cover the inner vessel wall are subjected to the hydrodynamic pressure gradients ...
arxiv   +1 more source

Investigating the suitability of high content image analysis as a tool to assess the reversibility of foamy alveolar macrophage phenotypes in vitro. [PDF]

, 2020
Many potential inhaled medicines fail during development due to the induction of a highly vacuolated or “foamy” alveolar macrophage phenotype response in pre-clinical studies.
Hoffman, Ewelina, Hutter, Victoria, Murnane, Darragh   +2 more
core   +1 more source