Results 21 to 30 of about 232,600 (377)

Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni

Molecules, 2015
Bornyl caffeate (1) was previously isolated by us from Valeriana (V.) wallichii rhizomes and identified as an anti-leishmanial substance. Here, we screened a small compound library of synthesized derivatives 1–30 for activity against schistosomula of ...
Jan Glaser, Uta Schurigt, Brian M. Suzuki, Conor R. Caffrey, Ulrike Holzgrabe   +4 more
doaj   +1 more source

Sulforaphane alters the acidification of the yeast vacuole

Microbial Cell, 2020
Sulforaphane (SFN) is a compound [1-isothiocyanato-4-(methylsulfinyl)-butane] found in broccoli and other cruciferous vegetables that is currently of interest because of its potential as a chemopreventive and a chemotherapeutic drug.
Alexander Wilcox, Michael Murphy, Douglass Tucker, David Laprade, Breton Roussel, Christopher Chin, Victoria Hallisey, Noah Kozub, Abraham Brass, Nicanor Austriaco   +9 more
doaj   +1 more source

Photosynthesis dependent acidification of perialgal vacuoles in theParamedum bursaria/Chlorella symbiosis. Visualization by monensin [PDF]

, 1992
After treatment with the carboxylic ionophore monensin theChlorella containing perialgal vacuoles of the greenParamecium bursaria swell. TheParamecium cells remain motile at this concentration for at least one day.
A Fischer, AM Tartakoff, AM Tartakoff, B Matzke, BC Pressmann, DC Smith, E Cernichiari, E Kessler, H Kleinig, HH Mollenhauer, J Larsen, J Willenbrink, L Muscatine, MJ Geisow, N Stelly, R Sandeaux, TC Hohman, W Reisser, W Reisser, W Reisser, W Reisser, WF Boss   +21 more
core   +1 more source

Identification of Fis1 Interactors in Toxoplasma gondii Reveals a Novel Protein Required for Peripheral Distribution of the Mitochondrion [PDF]

, 2020
Toxoplasma gondii’s single mitochondrion is very dynamic and undergoes morphological changes throughout the parasite’s life cycle. During parasite division, the mitochondrion elongates, enters the daughter cells just prior to cytokinesis, and undergoes ...
Arrizabalaga, Gustavo, Charvat, Robert, Jacobs, Kylie   +2 more
core   +1 more source

A case of VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) with decreased oxidative stress levels after oral prednisone and tocilizumab treatment

Frontiers in Medicine, 2022
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome has recently been described as an autoinflammatory disease associated with severe adult-onset inflammatory manifestations.
Nagie Tozaki, Chisato Tawada, Hirofumi Niwa, Yoko Mizutani, En Shu, Aki Kawase, Yuki Miwa, Hidenori Ohnishi, Hideo Sasai, Hideo Sasai, Keisuke Miyako, Junichi Hosokawa, Ayaka Kato, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Yohei Shirakami, Masahito Shimizu, Hiroaki Iwata   +17 more
doaj   +1 more source

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

PLoS Pathogens, 2016
Macrophages can be niches for bacterial pathogens or antibacterial effector cells depending on the pathogen and signals from the immune system. Here we show that type I and II IFNs are master regulators of gene expression during Legionella pneumophila ...
Jana Naujoks, C. Tabeling, B. D. Dill, C. Hoffmann, Andrew S. Brown, Mareike Kunze, S. Kempa, Andrea Peter, H. Mollenkopf, A. Dorhoi, O. Kershaw, A. Gruber, L. Sander, M. Witzenrath, S. Herold, A. Nerlich, A. Hocke, I. V. van Driel, N. Suttorp, S. Bedoui, H. Hilbi, M. Trost, B. Opitz   +22 more
semanticscholar   +1 more source

Freeze/thaw stress induces organelle remodeling and membrane recycling in cryopreserved human mature oocytes [PDF]

, 2016
Purpose: Our aim was to evaluate the ultrastructure of human metaphase II oocytes subjected to slow freezing and fixed after thawing at different intervals during post-thaw rehydration.
Albani, E., Borini, A., Coticchio, G., Levi Setti, P. E., Lorenzo, C., Macchiarelli, G., NOTTOLA, Stefania Annarita, Palmerini, M. G., Scaravelli, G.   +8 more
core   +1 more source

Investigating the suitability of high content image analysis as a tool to assess the reversibility of foamy alveolar macrophage phenotypes in vitro. [PDF]

, 2020
Many potential inhaled medicines fail during development due to the induction of a highly vacuolated or “foamy” alveolar macrophage phenotype response in pre-clinical studies.
Hoffman, Ewelina, Hutter, Victoria, Murnane, Darragh   +2 more
core   +2 more sources

A novel in vitro assay reveals SNARE topology and the role of Ykt6 in autophagosome fusion with vacuoles

Journal of Cell Biology, 2018
Autophagy is a catabolic pathway that delivers intracellular material to the mammalian lysosomes or the yeast and plant vacuoles. The final step in this process is the fusion of autophagosomes with vacuoles, which requires SNARE proteins, the homotypic ...
Jieqiong Gao, F. Reggiori, C. Ungermann
semanticscholar   +1 more source

Channeling the vacuole [PDF]

Nature Reviews Microbiology, 2018
Two recent studies provide new insights into the architecture, molecular mechanisms and function of the Plasmodium translocon of exported proteins (PTEX) complex and the core PTEX protein EXP2.
openaire   +2 more sources