Results 111 to 120 of about 218,284 (346)

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Vascular dementia has the highest hospitalisation rate in China: a nationwide hospital information system study

Stroke and Vascular Neurology
Background Although vascular dementia (VaD) is not uncommon in the hospital, most studies on VaD are community based. This study on VaD is the first to use a national hospital information system (HIS) in China.Methods This study was a hospital population-
Yongjun Wang, Yue Wang, Qi Zhou, Jiong Shi, Shiping Li   +4 more
doaj   +1 more source

Comparison of Intraoperative Doppler Flow Measurements and Algorithmic Flow Estimations in Patients Undergoing Durable Left Ventricular Assist Device Implantation

Artificial Organs, EarlyView.
Direct intraoperative HeartMate 3 LVAD flow measurements using an ultrasonic probe revealed consistently higher values by approximately 0.5 L/min compared to device‐estimated flows. This discrepancy remained stable across pump speed settings, highlighting the importance of distinguishing measured from estimated flow in HeartMate 3 patients.
Gaik Nersesian, Anna Stegmann, Daniel Lewin, Yuriy Hrytsyna, Leonard Pitts, Julius Kaemmel, Marian Kukucka, Alexander Mladenow, Lisa Garczarek, Julia Stein, Friedrich Kaufmann, Volkmar Falk, Evgenij Potapov, Pia Lanmueller   +13 more
wiley   +1 more source

Comparison of a Miniaturized Implantable Two‐Stage Rotodynamic Blood Pump to Equivalent Single‐Stage Concepts

Artificial Organs, EarlyView.
This study aims to evaluate the potential of a multistage pump design to enhance hemocompatibility in left ventricular assist devices. We found that the two‐stage concept offers favorable hemolysis measures compared to single‐stage designs, as the reduction in peak shear stresses outweighs the disadvantage associated with prolonged residence time ...
Sarah Linnemeier, Bente Thamsen, Stefan Maric, Bernhard Semlitsch, Benjamin Torner, Daniel Zimpfer, Marcus Granegger   +6 more
wiley   +1 more source

Device‐Induced Blood Damage in Pump‐Assisted Circulation: A Comparative Study of HeartMate III and BrioVAD Pumps

Artificial Organs, EarlyView.
Shear‐induced blood damage—including hemolysis, platelet and neutrophil injury, and von Willebrand factor (vWF) degradation—was evaluated for the BrioVAD and HM3 using an in vitro circulatory loop under clinically relevant conditions. Across 15 biomarkers (n > 6 per group), no significant differences were observed between the two devices.
Wenji Sun, Kiersten P. Clark, Douglas Tran, John C. Vandenberge, Nancy Kim, Shigang Wang, Anik Tarafder, Randy Perez, Bartley P. Griffith, Dong Han   +9 more
wiley   +1 more source

Updates on vascular dementia

Stroke and Vascular Neurology
Vascular dementia (VaD) is the second leading cause of dementia after Alzheimer’s disease (AD). In comparison to AD, there is a decline in the incidence of VaD due to recent improvements in cardiovascular risk factors. Brain hypoperfusion and hypoxia due
Jeffrey Chen, Wayne Feng, Sabrina Ng, Ava Hornblass, Parnian Habibi, Salman Ikramuddin, Dongming Cai   +6 more
doaj   +1 more source

The Role of Patients' Treatment Expectations in Ventricular Assist Device Support: Results From a Convergent Mixed Methods Study

Artificial Organs, EarlyView.
This mixed methods study aimed to: (i) identify treatment expectations held by individuals with a ventricular assist device (VAD), (ii) assess the extent to which these expectations have been met, and (iii) examine how treatment expectations relate to VAD‐specific health‐related quality of life (HRQoL) ABSTRACT Objectives Treatment expectations ...
Simon Felix Zerth, Bernd Niemann, Miriam Salzmann‐Djufri, Sandra Semmig‐Könze, Katharina Tigges‐Limmer, Yvonne Brocks, Monika Sadlonova, Anna Markser, Tanja Zimmermann, Lara Kristin Oldach, Stefan Salzmann   +10 more
wiley   +1 more source

Molecular Hydrogen Modulates T Cell Differentiation and Enhances Neuro-Regeneration in a Vascular Dementia Mouse Model

Antioxidants
This study explores whether molecular hydrogen (H2) administration can alleviate cognitive and immunological disturbances in a mouse model of vascular dementia (VaD).
Dain Lee, Hyunjun Jo, Jong-Il Choi
doaj   +1 more source

Shaping the Flow: Impact of Blade Shape on Performance and Hemocompatibility in Rotodynamic Blood Pumps

Artificial Organs, EarlyView.
Blade shapes (leading‐edge geometry and thickness) in rotodynamic blood pumps were systematically evaluated. Thinner blades improve pump efficiency by reducing blockage effects, while neither blade thickness nor leading‐edge geometry shows clear hemocompatibility benefits. Overall, blade shape has a limited impact on hemocompatibility, indicating it is
Benjamin Torner, Simon Klocker, Niccolò Crescenti, Aldo J. Suria, Harald Reithofer, Michael Hübler, Daniel Zimpfer, Marcus Granegger   +7 more
wiley   +1 more source

Changes in adiponectin system after ventricular assist device in pediatric heart failure

JHLT Open
Background: Ventricular assist device (VAD) implant represents a therapeutic option for pediatric patients with end-stage heart failure (HF). Heart unloading by VAD can modify several molecular pathways underlying cardiac function in HF.
Rosetta Ragusa, Arianna Di Molfetta, Alberto Mercatanti, Letizia Pitto, Antonio Amodeo, Maria Giovanna Trivella, Milena Rizzo, Chiara Caselli   +7 more
doaj   +1 more source