Results 81 to 90 of about 31,199 (169)

Molecular Hydrogen Modulates T Cell Differentiation and Enhances Neuro-Regeneration in a Vascular Dementia Mouse Model

Antioxidants
This study explores whether molecular hydrogen (H2) administration can alleviate cognitive and immunological disturbances in a mouse model of vascular dementia (VaD).
Dain Lee, Hyunjun Jo, Jong-Il Choi
doaj   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, Volume 36, Issue 18, 2 March 2026.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

In Situ Synthesis of Covalent Organic Frameworks Inside Cells for Triggering Ferroptosis and Immunotherapy

Advanced Materials, Volume 38, Issue 16, 17 March 2026.
We have developed an intracellular crystalline polymerization strategy involving acid‐catalyzed imine condensation to synthesize COFs in lysosomes. The generation of COFs in lysosomes damages their integrity, activates iron species, and induces immunogenic ferroptosis, thereby enhancing antitumor immunotherapy.
Qun Guan, Le‐Le Zhou, Zhiqing Yang, Yan‐An Li, Leyong Wang, Ruibing Wang   +5 more
wiley   +1 more source

Updates on vascular dementia

Stroke and Vascular Neurology
Vascular dementia (VaD) is the second leading cause of dementia after Alzheimer’s disease (AD). In comparison to AD, there is a decline in the incidence of VaD due to recent improvements in cardiovascular risk factors. Brain hypoperfusion and hypoxia due
Jeffrey Chen, Wayne Feng, Sabrina Ng, Ava Hornblass, Parnian Habibi, Salman Ikramuddin, Dongming Cai   +6 more
doaj   +1 more source

From Fiber Architecture to Functional Attachment: A Clinically Relevant, Mechanically Tunable Cardiac Patch

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
A personalizable platform featuring a multi‐zonal cardiac patch design at clinical scale enables precise customization of fiber architecture at micro‐ and macroscale via melt electrowriting. Distinct scaffold zones support cell alignment with mechanical force transfer and epicardial attachment.
Johannes Braig, Ross Kent, Ainitze Gereka Goienetxe, Nicolás Laita, Ming Wu, Miguel Ángel Martínez, Margarida Serra, Koen Janssens, Uzuri Urtaza, Eduardo Larequi, Ilazki Anaut‐Lusar, Hilde Gillijns, Michiel Algoet, Britt van Kerkhof, Maite van der Knaap, Gerardo Cedillo‐Servin, Miguel Castilho, Alain van Mil, Joost P. G. Sluijter, Jos Malda, Piet Claus, Peter H. M. Bovendeerd, Estefanía Peña, Manuel Doblare, Wouter Oosterlinck, Stefan Janssens, Ane M. Zaldua, Olalla Iglesias‐García, Felipe Prósper, Manuel M. Mazo Vega, Jürgen Groll, Tomasz Jüngst   +31 more
wiley   +1 more source

Changes in adiponectin system after ventricular assist device in pediatric heart failure

JHLT Open
Background: Ventricular assist device (VAD) implant represents a therapeutic option for pediatric patients with end-stage heart failure (HF). Heart unloading by VAD can modify several molecular pathways underlying cardiac function in HF.
Rosetta Ragusa, Arianna Di Molfetta, Alberto Mercatanti, Letizia Pitto, Antonio Amodeo, Maria Giovanna Trivella, Milena Rizzo, Chiara Caselli   +7 more
doaj   +1 more source

Depth‐Invariant High‐Resolution Optical Coherence Tomography Angiography

Advanced Photonics Research, Volume 7, Issue 3, March 2026.
Optical coherence tomography angiography (OCTA) has become an indispensable tool for visualizing and quantifying in vivo blood flow due to its motion‐contrast‐based label‐free flow detection capabilities. However, in various applications, its effectiveness is hindered by signal degradation due to scattering, absorption, and depth‐dependent defocus ...
ByungKun Lee, Seungwan Cho, Paul Shin, Gyounghwan Kim, Wang‐Yuhl Oh   +4 more
wiley   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, Volume 13, Issue 16, 18 March 2026.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

Letter to the Editor re: ‘How the factoid of wind turbines causing ‘vibroacoustic disease’ came to be ‘irrefutably demonstrated’

Australian and New Zealand Journal of Public Health, 2014
Mariana Alves‐Pereira, Nuno A. A. Castelo Branco   +1 more
doaj   +1 more source