Results 101 to 110 of about 24,033 (255)

Real‐world‐data for phenotypes and genotypes of rare monogenic genetic epilepsies and genes of uncertain significance for epilepsy

Epilepsia Open, EarlyView.
Abstract Objectives The objectives of this study were to develop a real‐world‐data (RWD) database for patients with epilepsy to provide further real‐world‐evidence (RWE) for monogenic genetic epilepsies; to assess the usefulness of a diagnostic algorithm in epilepsy; and to examine protein 3D structures using in silico tools to predict variant ...
Haley Morris, Elizabeth Mathew, Shalini Bahl, Marta Villa‐Lopez, Saadet Mercimek‐Andrews   +4 more
wiley   +1 more source

Effectiveness and safety of implantable vagus nerve stimulation in people with primary generalized tonic–clonic seizures

Epilepsia Open, EarlyView.
The impact of prompt diagnosis and treatment, and early predictors of outcome severity in this cohort. Abstract Objective Most therapies for drug‐resistant epilepsy (DRE) focus on focal‐onset seizures, the most common seizure types. Studying primary generalized tonic–clonic seizures (PGTCS) is more challenging due to diagnostic and recruitment ...
Katherine Eggleston, Justine Curley, Ryan Verner, Maxine Dibue, Charles Gordon, Gaia Giannicola, Kathryn Nichol   +6 more
wiley   +1 more source

Real‐world outcomes of responsive neurostimulation in patients with Lennox–Gastaut syndrome: A multicenter retrospective study

Epilepsia Open, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a severe developmental and epileptic encephalopathy (DEE) characterized by multiple seizure types and high resistance to antiseizure medication (ASM), often necessitating nonpharmacologic therapies, including neuromodulation.
Shanna M. Swartwood, Robert J. Bollo, Catherine J. Chu, Alexandra L. Geffrey, Robert Mark Richardson, Hiroki Nariai, Aria Fallah, Samuel Ahn, Saadi Ghatan, Laura Chenevert, Maite La Vega‐Talbott, Audie C. Espinoza   +11 more
wiley   +1 more source

Vagal nerve stimulator

, 2021
openaire   +2 more sources

Beyond seizures: A multidimensional approach to non‐seizure issues in Lennox–Gastaut syndrome. Insights from Italian experts

Epilepsia Open, EarlyView.
Abstract Non‐seizure issues (NSIs), including cognition, behavior/psychiatric symptoms, adaptive and social functioning, sleep, autonomic, and motor impairments, often shape day‐to‐day outcomes in Lennox–Gastaut syndrome (LGS) more than seizures, yet clinicians lack LGS‐specific, feasible assessment pathways.
Giancarlo Di Gennaro, Domenica Immacolata Battaglia, Paolo Bonanni, Gian Marco Duma, Antonietta Coppola, Edoardo Ferlazzo, Dario Pruna, Carlo Di Bonaventura   +7 more
wiley   +1 more source

A first in disease trial of the safety, tolerability, and anti‐seizure effects of ES‐481 in drug‐resistant epilepsy

Epilepsia Open, EarlyView.
Abstract Objectives ES‐481 is a novel potent and selective antagonist of TARP‐y8‐dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES‐481 as an add‐on anti‐seizure medication (ASM) in adults with drug‐resistant epilepsy (DRE). Methods This was a Phase 2A double‐blind,
Emma C. Foster, Lyn Millist, Jack Germaine, Stephanie Chamorro, Caitlin Roberts, John‐Paul Nicolo, Sean Hosking, Piero Perucca, Saul Mullen, Heather Robinson, Rebecca Wharrie, Brittany Walsh, David Reutens, Kimberley Irwin, Hao Zeng, Robert Niecestro, Terence J. O'Brien   +16 more
wiley   +1 more source

Relative entropy as a biomarker for vagus nerve stimulation response in epilepsy: Insights from intracerebral electroencephalography

Epilepsia Open, EarlyView.
Abstract Objective This study aims to analyze differences in pre‐implantation invasive electroencephalographic (IEEG) data between vagus nerve stimulation (VNS) responders (>50% seizure reduction) and VNS nonresponders (<50% seizure reduction). Methods We retrospectively identified 19 patients with drug‐resistant focal epilepsy who underwent IEEG ...
Štěpán Erben, Jan Cimbálník, Eva Zatloukalová, Petra Búřilová, Jan Vinklárek, Barbora Sklenárová, Jan Chrastina, Eva Brichtová, Jitka Kočvarová, Ondřej Strýček, Martin Pail, Milan Brázdil, Irena Doležalová   +12 more
wiley   +1 more source

Real‐world effectiveness of cenobamate in drug‐resistant and ultra‐refractory epilepsy: A multicenter study

Epilepsia Open, EarlyView.
Abstract Objective To evaluate the real‐world effectiveness, safety, and treatment retention of cenobamate (CNB) in patients with drug‐resistant epilepsy (DRE), including ultra‐refractory epilepsy (URE), high seizure burden, and extensive prior treatment history.
Ondřej Strýček, Jana Amlerová, Martin Pail, Jitka Kočvarová, Jana Slonková, Martin Šimčík, Kateřina Stanzelová, Monika Šibalová, Petr Marusič, Milan Brázdil   +9 more
wiley   +1 more source

The Roads of Rome for Functional Dyspepsia: From Rome I to Rome V

Gut Medicine, EarlyView.
ABSTRACT Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders. Its diagnostic, classificatory, and therapeutic concepts have continuously evolved alongside successive iterations of the Rome diagnostic criteria, undergoing profound changes over more than three decades.
Zi‐xing Qian, Wei Wei
wiley   +1 more source

Effect of Electromyography Findings of Traction‐Related Signal Loss on Prognosis During Neuromonitored Thyroidectomy

Head &Neck, EarlyView.
ABSTRACT Background Intraoperative neuromonitoring (IONM) is a reliable tool to detect electromyographic loss of signal (LOS). Here, we investigated the effect of electromyography features of traction‐related LOS on prognosis. Methods Thyroidectomy patients with a traction‐related LOS were included.
Serkan Karaisli, Selda Gucek Haciyanli, Emine Ozlem Gur, Mehmet Haciyanli   +3 more
wiley   +1 more source