Results 91 to 100 of about 9,384,833 (391)
Advanced Science, EarlyView.Maternal pregestational diabetes mellitus (PGDM) induced metabolic stress in fetal mice pancreas, alongside significantly decreased insulin secretion, altered cell‐cell communication, and distinct changes in cellular niches. Abstract Maternal pregestational diabetes mellitus (PGDM) can lead to adverse fetal outcomes, including lasting impacts on ...
Yu Deng +3 more
wiley +1 more source
The role of mutation rate variation and genetic diversity in the architecture of human disease [PDF]
, 2013 We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all genes that could cause disease have already been identified ...
arxiv +1 more source
Unveiling new disease, pathway, and gene associations via multi-scale neural networks [PDF]
PLOS ONE, 15(4), p.e0231059 (2020), 2019 Diseases involve complex processes and modifications to the cellular machinery. The gene expression profile of the affected cells contains characteristic patterns linked to a disease. Hence, biological knowledge pertaining to a disease can be derived from a patient cell's profile, improving our diagnosis ability, as well as our grasp of disease risks ...
arxiv +1 more source
Medicine in Microecology, 2021 In the 21st century, the incidence of preterm birth has continued to increase. According to statistics, preterm birth accounts for 5%–18% of all births worldwide, and 70%–75% of perinatal deaths are related to preterm birth.
Yuan Gao +3 more
doaj
Characteristics of vaginal delivery systems [PDF]
Arhiv za farmaciju, 2017 The lumen of vagina is the usual route for application of vaginal preparations with antimicrobial drug substances, however, good vascularisation and high permeability of the large surface of vaginal mucosa, as well as the circumvention of metabolic ...
Filipović Milica, Đekić Ljiljana
doaj +1 more source
Assessment of Risk Factors of Septic Complications of the Puerperium [PDF]
, 2018 Postpartum purulent-septic complications (PPSC) and their problems are most urgent for modern obstetrics due to their significant frequency. Maternal sepsis is one of the leading causes of maternal mortality around the world, accounting for about one ...
Feyta, Y. (Yuliya), Pyrohova, V. (Vira)
core +2 more sources
Advanced Science, EarlyView.ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma +18 more
wiley +1 more source
Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases.
New England Journal of Medicine, 2007 BACKGROUND A phase 3 trial was conducted to evaluate the efficacy of a prophylactic quadrivalent vaccine in preventing anogenital diseases associated with human papillomavirus (HPV) types 6, 11, 16, and 18.
S. Garland +18 more
semanticscholar +1 more source
Quantitative Bacteriology of the Vaginal Flora in Genital Disease [PDF]
Journal of Medical Microbiology, 1984 Samples from the posterior vaginal fornix of 102 women with various clinical conditions were analysed by a quantitative method. Aerobes were isolated from all but one of the specimens at a mean concentration of 7.2 log10 cfu/g and anaerobes from 92 specimens at a mean concentration of 8.1 log10 cfu/g.
R. N. Thin, Soad Tabaqchali, Mark Wilks
openaire +3 more sources
Advanced Science, EarlyView.This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu +10 more
wiley +1 more source