Results 51 to 60 of about 6,039 (129)

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

The Serotonergic and Cholinergic Signaling Pathways Drive Gastric Precancerous Lesions and Its Potential Mechanism

Cancer Science, EarlyView.
Vagal cholinergic neurons promote gastric 5‐HT secretion, which drives gastric precancerous lesions through 5‐HTR1D and TRPV4, highlighting these as candidate targets for early intervention. ABSTRACT Gastric cancer (GC) is a leading lethal malignancy globally. Gastric precancerous lesion (GPL) represents a critical step in GC, but its neural regulatory
Shengli Gao, Xufei Feng, Nana Zhang, Jia Su, Yuyan Wang, Linghan Kong, Jianing Zhou, Hui Dong, Feifei Guo   +8 more
wiley   +1 more source

Withdrawal and restoration of central vagal afferents within the dorsal vagal complex following subdiaphragmatic vagotomy

, 2013
Vagotomy, a severing of the peripheral axons of the vagus nerve, has been extensively utilized to determine the role of vagal afferents in viscerosensory signaling. Vagotomy is also an unavoidable component of some bariatric surgeries.
James H. Peters, Gallaher, Zachary R, Czaja, Krzysztof, Zachary R. Gallaher, Ryu, Vitaly, Krzysztof Czaja, Vitaly Ryu, Peters, James H   +7 more
core   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Effect of vagotomy and muscular paralysis on the MEPdia induced by a single TMS pulse at −6 mm from Bregma.

, 2014
A) Representative MEPdia before vagotomy, after vagotomy and injection of a paralytic agent (gallamine trietiodide) obtained with the “Unshielded” coil.
Stéphane Vinit (662867), Michel Petitjean (662872), Michael A. Lane (662871), Thérèse B. Deramaudt (538784), Victoria M. Spruance (662869), Tatiana Bezdudnaya (662870), Emilie Keomani (662868), Marcel Bonay (248093)   +7 more
core   +1 more source

Changes in intestinal endocrine cells in the mouse after unilateral cervical vagotomy [PDF]

, 1999
The effect of right or left unilateral cervical vagotomy on the intestinal endocrine cells was studied in 23 mice at 2 and 8 weeks after operation, respectively. The results were compared with that from 10 sham operated mice.
Danielsson, Åke,, Axelsson, H,, Shalaby, A, Qian, Bi-Feng,, el-Salhy, M,   +4 more
core   +1 more source

A Rare Case of Tubular Stomach in an 80-Year-Old Female Cadaver [PDF]

Journal of Clinical and Diagnostic Research
The stomach is a muscular bag that forms the most dilated part of the gastrointestinal tract. It serves as a reservoir for food and aids in the conversion of food into chyme under the influence of hydrochloric acid.
Monalisa mandal, Uma Shivanal, Vidya Chikkarahalli Srikantaiah, Manjunatha Hanasoge Narayana Gowda, Surabhi Mohan   +4 more
doaj   +1 more source

Effect of Physical Training on the Morphology of Parasympathetic Atrial Ganglia after Unilateral Vagotomy in Rats

Journal of Cardiovascular Development and Disease, 2022
Cardiac denervation is a serious problem in a number of patients, including patients after heart transplantation. The status of the parasympathetic ganglia after crossing the preganglionic fibers of the vagus nerve has not been enough studied. The aim of
Oleg V. Mamontov, Roman V. Grozov, Sarkis M. Minasian, Sergei G. Zhuravskii, Michael M. Galagudza, Alexei A. Kamshilin   +5 more
doaj   +1 more source

Fecal Microbiota Transplantation: A Promising Therapeutic Strategy Targeting the Microbiota–Gut–Brain Axis in Anorexia Nervosa

Brain and Behavior, Volume 16, Issue 11, November 2026.
Gut dysbiosis in anorexia nervosa may impair microbiota–gut–brain signaling through metabolic, immune, and vagal pathways. Fecal microbiota transplantation is being investigated as a potential strategy to restore host–microbiome balance, support a healthier microbial composition, and improve gastrointestinal function, appetite, and mood.
Shawn L. Kwok, Yu‐Chen Xiao, Xian‐Bin Cai   +2 more
wiley   +1 more source

Vagal subcircuits differentially regulate sepsis-induced sickness and anxiety-related behaviors

Cell Reports
Summary: The brain monitors peripheral immune activity via vagus nerve sensory neurons, whose cell bodies lie in the nodose ganglia and project to the brainstem dorsal vagal complex.
Lena Bourhy, Carine Moigneu, Alice Dupin, Esteban Delelis, Jarod Levy, Pierre-Marie Lledo, Tarek Sharshar, Gabriel Lepousez   +7 more
doaj   +1 more source