Results 81 to 90 of about 30,177 (304)

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Personalized multichannel transcranial direct current electrical stimulation (tDCS) in drug‐resistant epilepsy: A SEEG based open‐labeled study

Epilepsia Open, EarlyView.
Abstract Objective To evaluate the effects of personalized multichannel tDCS on seizure frequency, severity, quality of life, and psychiatric comorbidities in patients with drug‐resistant focal epilepsy. Secondary goals include assessing the safety and feasibility of this approach.
Fabrice Bartolomei, Maëva Daoud, Megane Delourme, Sophie Tardoski, Julia Makhalova, Eya Bourguiba, Samuel Medina Villalon, Stanislas Lagarde, Fabrice Wendling, Giulio Ruffini, Ricardo Salvador, Francesca Pizzo, Bernard Giusiano   +12 more
wiley   +1 more source

Resting‐state functional connectivity changes with microburst vagus nerve stimulation therapy

Epilepsia Open, EarlyView.
Abstract Objective Microburst vagus nerve stimulation (μVNS) may reduce seizure frequency in drug‐resistant epilepsy (DRE) via targeted thalamic plasticity. We prospectively investigated the role of thalamic resting‐state functional connectivity (rsFC) in μVNS effects and hypothesized a relationship between thalamic rsFC and long‐term seizure frequency
Jane B. Allendorfer, Rodolphe Nenert, Elhum Shamshiri, Giovanni Ranuzzi, Jason Begnaud, Ryan Verner, Jerzy P. Szaflarski, for the Microburst Study Group, Rebecca O’Dwyer, Michael Macken, Blake Newman, Cornelia Drees, Danielle McDermott, Lesley Kaye, Mesha Gay Brown, Muhammad Zafar, William Tatum, Selim Benbadis, Pegah Afra, Zeenat Jaisani, Kristl Vonck   +20 more
wiley   +1 more source

Bradycardia is induced by hyperactivity of the vagus nerve and nucleus ambiguus during seizures propagating into the brainstem

Epilepsia Open, EarlyView.
Abstract Objective Seizure‐induced bradycardia and asystole have been documented by video‐EEG monitoring periods in patients with epilepsy. This cardiac dysfunction during or after seizures may contribute to sudden unexpected death in epilepsy (SUDEP). Abnormal neurocardiac function during seizures could potentially be caused by seizures propagating to
Chia‐Chu Chiang, B. P. Kotamraju, Dominique M. Durand   +2 more
wiley   +1 more source

Vagus nerve stimulation for the treatment of narcolepsy

Brain Stimulation
No study on neurostimulation in narcolepsy is available until now. Arousal- and wake-promoting effects of vagus nerve stimulation (VNS) have been demonstrated in animal experiments and are well-known as side effects of VNS therapy in epilepsy and depression. The objective was to evaluate the therapeutic effect of VNS on daily sleepiness and cataplexies
Yaroslav Winter, Katharina Sandner, Claudio L.A. Bassetti, Martin Glaser, Dumitru Ciolac, Andreas Ziebart, Ali Karakoyun, Assel Saryyeva, Joachim K. Krauss, Florian Ringel, Sergiu Groppa   +10 more
openaire   +5 more sources

Late‐onset asystole associated with vagal nerve stimulation

Epilepsia Open, EarlyView.
Abstract Vagal nerve stimulation (VNS) is a form of neuromodulation that is an established adjunct in the management of drug‐resistant epilepsy. The common side effects of VNS are cough, dysphonia, or shortness of breath, which are often mild and do not require discontinuation of therapy.
Divya Nagabushana, Huan Huynh, Mark D. McCauley, Anna Serafini   +3 more
wiley   +1 more source

Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats

Journal of Neuroinflammation, 2012
Background In sepsis syndromes the severity of the inflammation triggers microvascular dysfunction and early organ failure. We studied the effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculatory integrity in an endotoxinemic
Mihaylova Stanka, Killian Anke, Mayer Konstantin, Pullamsetti Soni, Schermuly Ralph, Rosengarten Bernhard   +5 more
doaj   +1 more source

The landscape of epilepsy surgery in older adults: Challenges and opportunities

Epilepsia Open, EarlyView.
Abstract The prevalence of epilepsy increases with age, and with the aging population, the number of drug‐resistant epilepsy (DRE) cases is expected to rise. However, epilepsy surgery remains underutilized and is typically offered to younger adults. Despite historical hesitancy due to concerns over risks and outcomes, evidence over the last two decades
Vineet Punia
wiley   +1 more source

Ultrasound stimulation of the vagus nerve as a treatment modality for anxiety

Frontiers in Psychiatry
Anxiety is an increasingly prevalent mental disorder, causing widespread hardship and interfering with society’s economic progression. Standard treatments include various talk therapies with poor prognoses or drug interventions with complex side effects,
Michell Goyal, Ravi Goyal, Joseph L. Sanguinetti   +2 more
doaj   +1 more source

Effective weight control via an implanted self-powered vagus nerve stimulation device

Nature Communications, 2018
Developing new technologies for the neuromodulation of the vagus nerve can enable therapeutic strategies for body weight control in obese patients. Here, the authors present a battery-free self-powered implantable vagus nerve stimulation system that ...
Guang Yao, Lei Kang, Jun Li, Yin Long, Hao Wei, Carolina A. Ferreira, Justin J. Jeffery, Yuan Lin, Weibo Cai, Xudong Wang   +9 more
doaj   +1 more source