Results 11 to 20 of about 7,000 (133)

Repurposing Purine Analog Antivirals to Modulate Serum Uric Acid: Evidence From Real-World Data. [PDF]

Clin Transl Sci
ABSTRACT Xanthine oxidase (XO) inhibitors remain the standard pharmacologic therapy for hyperuricemia. However, additional enzymatic components of the purine degradation pathway may contribute to uric acid synthesis. Guanine deaminase (GD) catalyzes the conversion of guanine to xanthine, providing substrate for downstream oxidation by XO.
Magagnoli J, Cummings TH, Wyatt MD, McInnes C, Ambati J, Sutton SS.   +5 more
europepmc   +2 more sources

Modern aspects of tactics in the genital herpes viral infection (literature review) [PDF]

Гинекология, 2018
Genital herpes affects all population groups. 98% of the adult population worldwide have antibodies to the herpes simplex virus (HSV-1 or 2). This viral infection is a significant medical and social problem.
T Yu Pestrikova, E A Yurasova, I V Yurasov, A V Kotelnikova   +3 more
doaj   +1 more source

Modeling HIV disease progression and transmission at population-level: The potential impact of modifying disease progression in HIV treatment programs

Epidemics, 2018
Introduction: Mathematical models that incorporate HIV disease progression dynamics can estimate the potential impact of strategies that delay HIV disease progression and reduce infectiousness for persons not on antiretroviral therapy (ART).
Jennifer M. Ross, Roger Ying, Connie L. Celum, Jared M. Baeten, Katherine K. Thomas, Pamela M. Murnane, Heidi van Rooyen, James P. Hughes, Ruanne V. Barnabas   +8 more
doaj   +1 more source

Recurrent congenital cytomegalovirus infection in a sequential pregnancy with severe sequelae, and a possible association with prophylactic valacyclovir treatment: a case report

International Journal of Infectious Diseases, 2022
Recurrent congenital cytomegalovirus infections in consecutive pregnancies are rarely reported. Due to the risk of fetal infection from preconception maternal infection, a 6-month interval after primary maternal infection is generally advised before a ...
Tal Brosh-Nissimov, Neta Benshalom-Tirosh, Efrat Bucris, Hagar Morad, Neta S. Zuckerman, Michal Tepperberg Oikawa   +5 more
doaj   +1 more source

Antiviral Treatment of Maternal and Congenital Cytomegalovirus (CMV) Infections

Viruses, 2023
Human Cytomegalovirus (HCMV) is a ubiquitous member of the Herpesviridae family, responsible for the most common congenital viral infection—congenital Cytomegalovirus (cCMV) infection.
Swetha Pinninti, Suresh Boppana
doaj   +1 more source

Outcome of shared decision-making in a patient with primary herpes gingivostomatitis during pregnancy: a case report

Clinical and Experimental Obstetrics & Gynecology, 2020
Purpose: The authors present the case of a woman in the 20th week of pregnancy with herpes simplex virus (HSV)-related gingivostomatitis. They also provide information regarding the benefits and risks of acyclovir, valacyclovir, famciclovir, and shared ...
C.Y. Huang, T.C. Chao, H.C. Chien, Y.L. Liu   +3 more
doaj   +1 more source

Suppressive valacyclovir therapy to reduce genital herpes transmission: Good public health policy?

McGill Journal of Medicine, 2020
Genital herpes is a widespread sexually transmitted infection caused by the herpes simplex viruses (HSV). Suppressive valacyclovir therapy has been shown to significantly reduce HSV transmission.
Paul E Bonnar
doaj   +1 more source

The antiviral drug valacyclovir successfully suppresses salivary gland hypertrophy virus (SGHV) in laboratory colonies of Glossina pallidipes. [PDF]

PLoS ONE, 2012
Many species of tsetse flies are infected with a virus that causes salivary gland hypertrophy (SGH) symptoms associated with a reduced fecundity and fertility.
Adly M M Abd-Alla, Henry Adun, Andrew G Parker, Marc J B Vreysen, Max Bergoin   +4 more
doaj   +1 more source

UV Spectrophotometric Method for the Estimation of Valacyclovir HCl in Tablet Dosage Form

E-Journal of Chemistry, 2009
A simple, sensitive, highly accurate UV spectrophotometric method has been developed for the determination of valacyclovir in bulk and tablet dosage form. Solution of valacyclovir in 0.1N HCl shows maximum absorbance at 255 nm.
M. Ganesh, C. V. Narasimharao, A. Saravana Kumar, K. Kamalakannan, M. Vinoba, H. S. Mahajan, T. Sivakumar   +6 more
doaj   +1 more source

Valacyclovir: A Comparative Analysis of Pharmacopoeial Quality Requirements

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Lack of national requirements regulating the quality of valacyclovir hydrochloride active pharmaceutical ingredient (API) in hydrated form and valacyclovir medicinal products may be challenging not only for manufacturers, but also for ...
K. S. Arhipova, E. L. Kovaleva, A. R. Fazylova, A. S. Nemсova   +3 more
doaj   +1 more source