Results 31 to 40 of about 8,947 (130)

Pediatric Dosing of Ganciclovir and Valganciclovir: How Model‐Based Simulations Can Prevent Underexposure and Potential Treatment Failure

CPT: Pharmacometrics & Systems Pharmacology, 2019
Intravenous ganciclovir and oral valganciclovir are effective in the prevention and treatment of pediatric cytomegalovirus (CMV) infection but various dosing regimens are used in medical practice.
Karin Jorga, Bruno Reigner, Clarisse Chavanne, Giuseppe Alvaro, Nicolas Frey   +4 more
doaj   +1 more source

Treatment of cytomegalovirus anterior segment infection with intravitreal injection of ganciclovir in adjunction with or without oral valganciclovir: a long-term results

Scientific Reports, 2021
We evaluated the therapeutic outcome of intravitreal injection (IVI) of ganciclovir with/without oral valganciclovir for cytomegalovirus (CMV) anterior segment infection.
Yu-Chun Cheng, Eugene Yu-Chuan Kang, Yih-Shiou Hwang, Ching-Hsi Hsiao   +3 more
doaj   +1 more source

Role of extracorporeal membrane oxygenation in the management of myocarditis during caesarean birth

Anaesthesia Reports, Volume 14, Issue 2, July‐December 2026.
Summary We describe a pregnant patient who presented in labour with diffuse ST‐segment elevation on electrocardiography and biochemical evidence of myocardial injury. Transthoracic echocardiography showed severe biventricular dysfunction. An urgent caesarean birth was indicated due to breech presentation and severe cardiac dysfunction.
Y. Hasan, A. Engdahl, F. Kromah, A. Karuppiah   +3 more
wiley   +1 more source

Acute Liver Injury Following Outpatient Trimethoprim‐Sulfamethoxazole Use for Small Intestinal Bacterial Overgrowth: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Drug‐induced liver injury (DILI) is a leading cause of acute liver failure in the United States and remains difficult to predict and diagnose. Trimethoprim‐sulfamethoxazole (TMP‐SMX) is widely prescribed and generally well tolerated, yet rare cases of severe idiosyncratic hepatotoxicity have been reported.
Kaylie Duit, Joseph Rattenni, Lauryn Hanson, Aaron R. Kunz   +3 more
wiley   +1 more source

A case of successful contribution of therapeutic drug monitoring of valganciclovir as the prophylaxis against cytomegalovirus infection in a lung transplant recipient

Journal of Pharmaceutical Health Care and Sciences
Background Ganciclovir and its prodrug, valganciclovir, are first-line agents for cytomegalovirus infection prophylaxis after lung transplantation. Although valganciclovir prophylaxis is known to result in severe leukopenia as an adverse effect, dosage ...
Yoshiki Katada, Keisuke Umemura, Shunsaku Nakagawa, Yurie Katsube, Masahiro Tsuda, Satona Tanaka, Hiroshi Date, Miki Nagao, Tomohiro Terada   +8 more
doaj   +1 more source

Surveillance of CMV Terminase Gene Mutations in Allogeneic Hematopoietic Stem Cell Transplant Recipients Receiving Letermovir Prophylaxis

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Letermovir (LMV), a CMV‐specific terminase inhibitor, is recommended for cytomegalovirus (CMV) prophylaxis in CMV‐seropositive allogeneic hematopoietic stem cell transplant (alloHSCT) recipients. The association between low‐level CMV DNAemia during prophylaxis and the emergence of mutations in CMV terminase complex genes remains unclear.
Amandine Caillault, Alienor Xhaard, Severine Mercier‐Delarue, Linda Feghoul, Julien Robert, Nathalie Schnepf, David Michonneau, Marie Robin, Flore Sicre de Fontbrune, Eleonore Kaphan, Mathilde Ruggiu‐Goiran, Pedro Henrique de Lima Prata, Florian Chevillon, Matthieu Jestin, Nathalie Dhedin, Gerard Socie, Régis Peffault de Latour, Maud Salmona, Jérôme LeGoff   +18 more
wiley   +1 more source

Model Ensembling and Machine Learning Approaches to Predict the First Dose of Amoxicillin in Intensive Care

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT A priori model‐informed precision dosing (MIPD) recommends an appropriate first dose based solely on the patient's covariates enabling faster target attainment without required concentration measurements. Population pharmacokinetic (PopPK) model ensembling and machine learning (ML) approaches were developed and evaluated to predict a first ...
Mihály Leiwolf, Nicolas Gregoire, Sophie Magréault, Bénédicte Franck, Ombeline Krekounian, Jean‐Baptiste Woillard, Vincent Aranzana‐Climent   +6 more
wiley   +1 more source

Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection

Clinical Ophthalmology, 2012
Victoria WY Wong, Carmen KM Chan, Dexter YL Leung, Timothy YY LaiDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong, People's Republic of ChinaBackground: The purpose of this ...
Wong VW, Chan CK, Leung DY, Lai TY
doaj  

Herpes Simplex Virus Hepatitis: An Overlooked Cause of Acute Liver Failure Across a Broad Spectrum of Immunocompromise

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Background and Aims Herpes simplex virus (HSV) infection is common worldwide, but hepatic involvement is rare. HSV hepatitis is an uncommon yet frequently catastrophic cause of acute hepatitis and acute liver failure (ALF), accounting for < 1% of ALF cases while carrying very high mortality when diagnosis and antiviral therapy are delayed ...
Mario U. Mondelli, Serena Ludovisi, Angela Di Matteo, Gülşen Özkaya Şahin, William Irving, European Society of Clinical Microbiology and Infectious Diseases Study Group for Viral Hepatitis (ESGVH)   +5 more
wiley   +1 more source

Effectiveness of Valganciclovir 900mg Versus 450mg for Cytomegalovirus Prophylaxis in Renal Transplantation: A Systematic Review and Meta-Analysis

Journal of Pharmacy & Pharmaceutical Sciences, 2017
Objectives: Valganciclovir 900 mg/day is approved for cytomegalovirus (CMV) prophylaxis, but 450 mg/day is seems also effective. We systematically reviewed the efficacy and safety of low-dose versus high-dose valganciclovir prophylaxis in renal ...
wang xin, yang hui, zhang xiaodong, cui xiangli, wang shihui, liu lihong   +5 more
doaj   +1 more source