Results 21 to 30 of about 3,785 (146)

Valganciclovir for cytomegalovirus prevention in solid organ transplant patients: an evidence-based reassessment of safety and efficacy. [PDF]

PLoS ONE, 2009
BACKGROUND:Several anti-viral drugs have demonstrated efficacy in preventing Cytomegalovirus (CMV) infections in solid organ transplant (SOT) patients.
Andre C Kalil, Alison G Freifeld, Elizabeth R Lyden, Julie A Stoner   +3 more
doaj   +1 more source

Development and Validation of Valganciclovir and its Active Metabolite Ganciclovir Determination in Human Plasma by HPLC-MS/MS Method

Разработка и регистрация лекарственных средств, 2021
Introduction. Currently, physicochemical methods of quantification are actively used to determine the content of drugs in biological fluids. High-performance liquid chromatography with various detection methods is particularly widespread. One of the most
T. N. Komarov, I. E. Shohin, M. A. Tokareva, O. A. Archakova, D. S. Bogdanova, A. V. Aleshina, N. S. Bagaeva, V. V. Davydanova   +7 more
doaj   +1 more source

Treatment for First Cytomegalovirus Infection Post–Hematopoietic Cell Transplant in the AURORA Trial: A Multicenter, Double-Blind, Randomized, Phase 3 Trial Comparing Maribavir With Valganciclovir

Clinical Infectious Diseases, 2023
Background Neutropenia may limit the use of valganciclovir treatment for cytomegalovirus (CMV) infection following hematopoietic cell transplant (HCT).
G. Papanicolaou, Robin K Avery, Catherine Cordonnier, Rafael F Duarte, Shariq Haider, J. Maertens, K. Peggs, C. Solano, Jo-Anne H. Young, Martha Fournier, Rose Ann Murray, Jingyang Wu, Drew J. Winston   +12 more
semanticscholar   +1 more source

Development and Validation of Valganciclovir and its Active Metabolite Ganciclovir Determination in Human Plasma by HPLC-UV Method

Разработка и регистрация лекарственных средств, 2020
Introduction. Viral infections are a serious problem that occurs during the use of immunosuppressants in preparation for organ transplantation and in the postoperative period.
T. N. Komarov, I. E. Shohin, O. A. Miskiv, D. S. Bogdanova, A. V. Aleshina, Yu. V. Medvedev, N. S. Bagaeva   +6 more
doaj   +1 more source

Treatment of congenital cytomegalovirus infection [PDF]

Clinical and Experimental Pediatrics, 2023
Congenital cytomegalovirus (CMV) is the most common cause of congenital infection worldwide, the most common nongenetic cause of sensorineural hearing loss in children, and a cause of neurodevelopmental disorders in the brain.
Gyu Hong Shim
doaj   +1 more source

Targeted therapy with nanatinostat and valganciclovir in recurrent EBV-positive lymphoid malignancies: a phase 1b/2 study

Blood Advances, 2023
Key Points • Nanatinostat plus valganciclovir is a novel oral regimen for relapsed/refractory EBV+ lymphoma that warrants further investigation.• Encouraging efficacy and safety were observed across a variety of EBV+ lymphoma subtypes.
B. Haverkos, O. Alpdogan, R. Baiocchi, J. Brammer, T. Feldman, M. Capra, Elizabeth A. Brem, S. Nair, P. Scheinberg, J. Pereira, L. Shune, E. Joffe, P. Young, S. Spruill, A. Katkov, R. McRae, I. Royston, D. Faller, L. Rojkjaer, P. Porcu   +19 more
semanticscholar   +1 more source

Valganciclovir Inhibits Human Adenovirus Replication and Pathology in Permissive Immunosuppressed Female and Male Syrian Hamsters

Viruses, 2015
Adenovirus infections of immunocompromised pediatric hematopoietic stem cell transplant patients can develop into serious and often deadly multi-organ disease. There are no drugs approved for adenovirus infections.
Karoly Toth, Baoling Ying, Ann E. Tollefson, Jacqueline F. Spencer, Lata Balakrishnan, John E. Sagartz, Robert Mark L. Buller, William S. M. Wold   +7 more
doaj   +1 more source

Valganciclovir as Add-On to Standard Therapy in Secondary Glioblastoma

Microorganisms, 2020
Patients with glioblastoma have a very poor prognosis despite aggressive therapeutic strategies. Cytomegalovirus has been detected in >90% of glioblastoma tumors.
Giuseppe Stragliotto, Mattia Russel Pantalone, Afsar Rahbar, Cecilia Söderberg-Nauclér   +3 more
doaj   +1 more source

Treating HIV-associated cytomegalovirus retinitis with oral valganciclovir and intra-ocular ganciclovir by primary HIV clinicians in southern Myanmar: a retrospective analysis of routinely collected data

BMC Infectious Diseases, 2020
Background Cytomegalovirus retinitis (CMVR) is an opportunistic infection in HIV-infected people. Intraocular or intravenous ganciclovir was gold standard for treatment; however, oral valganciclovir replaced this in high-income countries. Low- and middle-
Jillian Murray, Adelene Hilbig, Theint Thida Soe, Win Le Shwe Sin Ei, Kyi Pyar Soe, Iza Ciglenecki   +5 more
doaj   +1 more source

Role of Valganciclovir in Children with Congenital CMV Infection: A Review of the Literature

Children, 2023
Background: Cytomegalovirus (CMV) is the most common agent of congenital infection in humans. It is a main cause of neurodevelopmental delay and sensorineural hearing loss in infancy.
D. Pata, Danilo Buonsenso, Arianna Turriziani-Colonna, Gilda Salerno, L. Scarlato, L. Colussi, Rolando Ulloa-Gutierrez, P. Valentini   +7 more
semanticscholar   +1 more source