Results 71 to 80 of about 3,785 (146)

Challenges for the improvement of valganciclovir prophylaxis in solid organ transplantation and the possible role of therapeutic drug monitoring in adults

British Journal of Clinical Pharmacology
Cytomegalovirus (CMV) infection frequently occurs after solid organ transplantation and is associated with an increased morbidity and mortality. Fortunately, the development of valganciclovir prophylaxis has lowered the incidence of CMV infection and its
Lukas K van Vugt, D. Hesselink, B. D. de Winter   +2 more
semanticscholar   +1 more source

Human Cytomegalovirus Infection in Haematopoietic Stem Cell Transplant Recipients and CAR‐T Cell Recipients—PART 2: Antiviral Therapy and Virus‐Specific T Cell Therapy for HCMV in Allo‐HSCT

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT Human cytomegalovirus (HCMV) reactivation is a common and significant complication after allogeneic haematopoietic stem cell transplantation (allo‐HSCT), causing potentially life‐threatening disease. Antiviral therapy approaches for HCMV are often limited by toxicities and the risk of developing antiviral drug resistance.
Gaurav Sutrave, Michelle K. Yong, Danya Kaplan, David J. Gottlieb, Allison Abendroth, Barry Slobedman, Emily Blyth, Lauren Stern   +7 more
wiley   +1 more source

Cytomegalovirus Antiviral Resistance Among Kidney Transplant Recipients in a Phase 3 Trial of Letermovir vs Valganciclovir Prophylaxis

Journal of Infectious Diseases
Background In a phase 3 trial, letermovir was noninferior to valganciclovir for cytomegalovirus (CMV) disease prophylaxis in kidney transplant recipients who were CMV-seronegative and received kidneys from donors who were CMV-seropositive.
Julie M. Strizki, Tracy L. Diamond, Valerie L Teal, Christopher L. Gilbert, Weiwen Wang, Nicole Stauffer, Barbara Haber   +6 more
semanticscholar   +1 more source

Congenital CMV and Hearing Loss—How Does it Happen and How to Prevent it

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT Congenital cytomegalovirus (cCMV) is found worldwide and significantly contributes to permanent childhood hearing loss. CMV has been known to cause sensorineural hearing loss (SNHL) for more than half a century, and CMV‐related hearing loss has consistently been present in all childhood populations where infants with cCMV have been identified ...
Karen B. Fowler
wiley   +1 more source

Cytomegalovirus retinitis treated with valganciclovir in Wegener’s granulomatosis

Clinical Ophthalmology, 2012
Yoshiaki Kabata1, Genichiro Takahashi1, Hiroshi Tsuneoka21Department of Ophthalmology, Jikei University School of Medicine, Katsushika Medical Center, Katsushika, Tokyo, Japan; 2Department of Ophthalmology, Jikei University School of Medicine, Minato ...
Kabata Y, Takahashi G, Tsuneoka H
doaj  

Efficacy of Low Dose Valganciclovir Prophylaxis for Cytomegalovirus Infection in Kidney Transplantation

Haseki Tıp Bülteni, 2020
Aim:Valganciclovir is the preferred drug for chemoprophylaxis for the prevention of cytomegalovirus (CMV) infection in kidney recipients. Low-dose (450 mg/day) valganciclovir use is gaining popularity because standard dose (900 mg/day) has negative ...
Ümit Özçelik, Nadir Alpay, Eryiğit Eren, Bora Uslu, Ahmet Cem Yardımcı   +4 more
doaj   +1 more source

Onset of valganciclovir resistance in two infants with congenital cytomegalovirus infection

International Journal of Infectious Diseases, 2020
Ganciclovir and its prodrug valganciclovir are elective treatments for cCMV. Neonates with important symptoms undergo 6 months of therapy to ameliorate/prevent symptoms and late sequelae, but evidence of resistance is emerging.
Francesca Garofoli, Giuseppina Lombardi, Micol Angelini, Giulia Campanini, Maurizio Zavattoni, Fausto Baldanti   +5 more
doaj   +1 more source

Rescue by Hypothermic Oxygenated Machine Perfusion for Unexpected Long Prolongation of Cold Preservation Time in Expanded Criteria Donor Kidneys Can Achieve Favorable 2‐Year Outcomes

Clinical Transplantation, Volume 40, Issue 5, May 2026.
ABSTRACT Background Hypothermic oxygenated machine perfusion (HOPE) is occasionally used to overcome logistical issues and allow longer cold preservation time (CPT); however, reports regarding these situations in older brain‐dead donors are lacking.
Silvia Mingozzi, Alberto Mella, Caterina Dolla, Ester Gallo, Ana Maria Manzione, Enrico Sanna, Paolo Randone, Rita Tarragoni, Roberta Giraudi, Gloria Giovinazzo, Claudia Melloni, Aldo Verri, Andrea Bosio, Paolo Gontero, Antonella Barreca, Fabrizio Fop, Luigi Biancone   +16 more
wiley   +1 more source

The Use of Pediatric Donors in Pancreas Transplantation

Clinical Transplantation, Volume 40, Issue 5, May 2026.
ABSTRACT Introduction The use of pediatric donors in simultaneous pancreas‐kidney transplantation (SPKT) and solitary pancreas transplantation is not universally accepted Methods Single center retrospective review of 310 consecutive SPKTs and 50 solitary pancreas transplants performed from 11/1/01 to 1/1/25.
Arianna Cabrales, Rana Kumar, Christopher Webb, Emily McCracken, Colleen L. Jay, Giuseppe Orlando, Alan C. Farney, Robert J. Stratta   +7 more
wiley   +1 more source

Effectiveness of Valganciclovir 900mg Versus 450mg for Cytomegalovirus Prophylaxis in Renal Transplantation: A Systematic Review and Meta-Analysis

Journal of Pharmacy & Pharmaceutical Sciences, 2017
Objectives: Valganciclovir 900 mg/day is approved for cytomegalovirus (CMV) prophylaxis, but 450 mg/day is seems also effective. We systematically reviewed the efficacy and safety of low-dose versus high-dose valganciclovir prophylaxis in renal ...
wang xin, yang hui, zhang xiaodong, cui xiangli, wang shihui, liu lihong   +5 more
doaj   +1 more source