Results 1 to 10 of about 707 (102)

Response of Microbial Communities in the Tobacco Phyllosphere Under the Stress of Validamycin [PDF]

Frontiers in Microbiology, 2023
Validamycin, is classified as an environmentally friendly fungicide. It has high efficacy with little associated pollution risk, and it has been used in China on tobacco for many years especially during leaf spot season.
Thomas Hsiang, Moyan Guo, Caihua Shi
exaly   +4 more sources

Validamycin Inhibits the Synthesis and Metabolism of Trehalose and Chitin in the Oriental Fruit Fly, Bactrocera dorsalis (Hendel) [PDF]

Insects, 2023
The oriental fruit fly, Bactrocera dorsalis (Hendel), is a notorious invasive pest that has raised concerns worldwide. Validamycin has been demonstrated to be a very strong inhibitor against trehalase in a variety of organisms.
Ying Li, Yonghong Xu, Shunjiao Wu, Baohe Wang, Yaying Li, Yinghong Liu, Jia Wang   +6 more
doaj   +2 more sources

Trehalase Inhibitor Validamycin May Have Additional Mechanisms of Toxicology against Rhizoctonia cerealis [PDF]

Journal of Fungi, 2023
Sharp eyespot is a crucial disease affecting cereal plants, such as bread wheat (Triticum aestivum) and barley (Hordeum vulgare), and is primarily caused by the pathogenic fungus Rhizoctonia cerealis.
Xiaoyue Yang, Yan Shu, Shulin Cao, Haiyan Sun, Xin Zhang, Aixiang Zhang, Yan Li, Dongfang Ma, Huaigu Chen, Wei Li   +9 more
doaj   +2 more sources

Validamycin Inhibits the Reproductive Capacity of Spodoptera frugiperda (Lepidoptera: Noctuidae) by Suppressing the Activity of Trehalase [PDF]

Insects
Spodoptera frugiperda (J. E. Smith, 1797), an omnivorous crop pest worldwide, reproduces prolifically. Validamycin, a competitive natural inhibitor of trehalase, is regarded as an effective and safe insecticide.
Fan Zhong, Sijing Wan, Shangrong Hu, Yuxin Ge, Ye Han, Xinyu Zhang, Min Zhou, Yan Li, Bin Tang   +8 more
doaj   +2 more sources

Validamycin Ingestion: A Rare Case of Poisoning With a Surprisingly Benign Outcome – Our Experience in a Resource‐Limited Emergency Setting [PDF]

Clinical Case Reports
Validamycin ingestion is a rare encounter in emergency settings. There is no specific antidote, with management being largely symptomatic. Overzealous treatment and referral to higher centers are not necessary, as consumption of even large doses of ...
Anish Luitel, Sweekar Dahal, Kabita Yadav, Bodhraj Budhathoki, Chandan Chaudary, Rasmita Poudel   +5 more
doaj   +2 more sources

Effects of Trehalase on the Gene Expression of the Reproductive Regulation Pathway Network and Triglyceride Metabolism in Nilaparvata lugens (Stål) [PDF]

Insects
The high reproductive performance of Nilaparvata lugens (Stål) (Hemiptera: Delphacidae) is one of the key factors contributing to its serious damage. Studies have demonstrated that trehalose hydrolysis, catalyzed by trehalase (TRE), plays an important ...
Bin Tang, Yuxin Ge, Yongkang Liu, Liwen Guan, Ye Han, Yang Zhu, Gao Hu, Yan Wu   +7 more
doaj   +2 more sources

Anopheles gambiae Trehalase Inhibitors for Malaria Vector Control: A Molecular Docking and Molecular Dynamics Study [PDF]

Insects, 2022
Trehalase inhibitors are considered safe alternatives for insecticides and fungicides. However, there are no studies testing these compounds on Anopheles gambiae, a major vector of human malaria.
Eunice O. Adedeji, Gbolahan O. Oduselu, Olubanke O. Ogunlana, Segun Fatumo, Rainer Koenig, Ezekiel Adebiyi   +5 more
doaj   +2 more sources

Distinct Roles of Two UDP-N-Acetylglucosamine Pyrophosphorylase Genes in Chitin Biosynthesis and Molting of Oedaleus asiaticus (Orthoptera: Acrididae) [PDF]

Insects
UDP-N-acetylglucosamine pyrophosphorylase (UAP) is an essential enzyme in the insect chitin biosynthesis pathway; however, little is known regarding its molecular functions in Oedaleus asiaticus Bey-Bienko (Orthoptera: Acrididae).
Hai-Yan Gao, Feng Yan, Elahe Rostami, Mei Liu, Jie Zhao, Yu Zhang, Shu-Jing Gao   +6 more
doaj   +2 more sources

Comparative transcriptomic and metabolomics analysis of ovary in Nilaparvata lugens after trehalase inhibition [PDF]

BMC Genomics
The fecundity of Nilaparvata lugens (brown planthopper) is influenced by trehalase (TRE). To investigate the mechanism by which trehalose affects the reproduction of N.
Yongkang Liu, Fan Yang, Sijing Wan, Xianzhong Wang, Liwen Guan, Yan Li, Caidi Xu, Binghua Xie, Shigui Wang, Xiao-Ling Tan, Bin Tang   +10 more
doaj   +2 more sources

Identification of Bacterial Oligopeptidase B Inhibitors from Microbial Natural Products: Molecular Insights, Docking Studies, MD Simulations, and ADMET Predictions [PDF]

Pharmaceuticals
Background/Objectives: The increasing threat of antibiotic resistance and the declining efficiency of traditional drug discovery pipelines highlight the urgent need for novel drug targets and effective enzyme inhibitors against infectious diseases ...
Malik Suliman Mohamed, Tilal Elsaman, Magdi Awadalla Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla, Mona Timan Idriss   +5 more
doaj   +2 more sources