Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
A Network Toxicology Approach for Mechanistic Modelling of Nanomaterial Hazard and Adverse Outcomes
Advanced ScienceHazard assessment is the first step in evaluating the potential adverse effects of chemicals. Traditionally, toxicological assessment has focused on the exposure, overlooking the impact of the exposed system on the observed toxicity.
Giusy del Giudice +9 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Reducing the Probability of False Positive Research Findings by Pre-Publication Validation - Experience with a Large Multiple Sclerosis Database [PDF]
, 2007 *Objective* We have assessed the utility of a pre-publication validation policy in reducing the probability of publishing false positive research findings.
George G. Ebers +5 more
core +1 more source
A novel Bayesian strategy for the identification of spatially varying material properties and model validation: an application to static elastography [PDF]
, 2012 Phaedon‐Stelios Koutsourelakis
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Adoption of mechanization alternatives in oil palm crops in the Colombian Orinoquía natural region☆
Oilseeds and fats, crops and lipidsThe Orinoquía Natural Region in Colombia, particularly the Cumaral and Bajo Upía subzone, serves as the country’s primary palm oil production area. However, it faces with labor shortages and a lack of current mechanization data. This study aims to assess
Zapata-Hernández Arley +4 more
doaj +1 more source
The effect of laser stitch welding residual stress on the dynamic behaviour of thin steel structure
Journal of Mechanical Engineering and Sciences, 2019 Laser stitch welding is one of the most reliable and efficient permanent metal joining processes in the automotive industry, particularly in the manufacturing of a car body-in-white (BIW).
M. A. S. Aziz Shah +5 more
doaj +1 more source
An empirical learning-based validation procedure for simulation workflow
, 2018 Simulation workflow is a top-level model for the design and control of simulation process. It connects multiple simulation components with time and interaction restrictions to form a complete simulation system.
Lai, Liyuanjun, Liu, Zhuqing, Zhang, Lin
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source