Results 61 to 70 of about 6,125,000 (281)

Validation of nonlinear PCA

, 2012
Linear principal component analysis (PCA) can be extended to a nonlinear PCA by using artificial neural networks. But the benefit of curved components requires a careful control of the model complexity.
A Herman, A Ilin, AN Gorban, B Chalmond, B Christiansen, B Efron, B Schölkopf, BW Lu, D DeMers, JB Tenenbaum, LK Saul, M Scholz, MA Kramer, Matthias Scholz, MR Hestenes, ND Lawrence, P Demartines, R Hecht-Nielsen, S Girard, S Harmeling, S Mika, ST Roweis, T Hastie, T Kohonen, WW Hsieh, WW Hsieh, WW Hsieh   +26 more
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

An Adaptive Dark-Target Algorithm for Retrieving Land AOD Applied to FY-4B/AGRI Data

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The Fengyun 4B (FY-4B) as an operational satellite was launched on 3 June 2021. The advanced geostationary radiation imager (AGRI) aboard on the FY-4B has ability to monitor aerosols information.
Yidan Si, Ling Gao, Lin Chen, Qiaoxu Tan, Xingying Zhang, Bo Li, Huanhuan Yan, Xiaohu Zhang, Feng Lu, Xiaohan Zhang   +9 more
doaj   +1 more source

Behavioural study of PEMFC during start-up/shutdown cycling for aeronautic applications

Materials for Renewable and Sustainable Energy, 2019
The deployment of proton exchange membrane fuel cell (PEMFC) for aeronautic applications is a value-added energy supply alternative that not only generates useful byproducts (oxygen-depleted air, water and heat) but addresses sensitive issues such as ...
Noluntu Dyantyi, Adrian Parsons, Piotr Bujlo, Sivakumar Pasupathi   +3 more
doaj   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Fast Cross-Validation via Sequential Testing [PDF]

, 2015
With the increasing size of today's data sets, finding the right parameter configuration in model selection via cross-validation can be an extremely time-consuming task.
Braun, Mikio, Krueger, Tammo, Panknin, Danny   +2 more
core  

Protein kinase FAM20C—when subcellular localization matters

FEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Asprosin Aggravates Tubular Epithelial Cell Injury and Phenotypic Transformation via Mitochondrial Dynamics Disorder Mediated by Excessive Drp1 SUMOylation in Diabetic Nephropathy Mice

Advanced Science
Epidemiological studies show that some diabetic patients develop end‐stage renal dysfunction without significant proteinuria or glomerulopathy, underscoring the role of renal tubular epithelial cell (TEC) impairment in diabetic kidney disease (DKD ...
Qianqian Huang, Xiaowei Xiong, Sheng Chen, Yuan Wang, Li Wang, Wentao Liu, Chen Liu, Guohua Zeng, Qiren Huang   +8 more
doaj   +1 more source

Model validation of spatiotemporal systems using correlation function tests [PDF]

, 2006
Model validation is an important and essential final step in system identification. Although model validation for nonlinear temporal systems has been extensively studied, model validation for spatiotemporal systems is still an open question.
Billings, S.A., Pan, Y.
core