FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
A Formal Validation Approach for XACML 3.0 Access Control Policy. [PDF]
Sensors (Basel), 2022 Caserio C, Lonetti F, Marchetti E.
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of <i>Stigmasterol</i> in the Treatment of Rheumatoid Arthritis. [PDF]
Drug Des Devel Ther, 2023 Xie W, Yang H, Guo C, Xie R, Yu G, Li Y.
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A hybrid approach for Bengali sentence validation
Artificial Intelligence ReviewAbstractBengali is the official language of Bangladesh and is widely used in Bangladesh and West Bengal in India. Due to the growing accessibility of the internet and smart devices, the use of digital text material and documents in Bengali is growing with time.
Juel Sikder +3 more
openaire +1 more source
A model for early failure prediction of blood pressure measurement devices in a stepped validation approach. [PDF]
J Clin Hypertens (Greenwich), 2022 Vischer AS +3 more
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Prediction and experimental validation approach to improve performance of novel hybrid bio-inspired 3D printed lattice structures using artificial neural networks. [PDF]
Sci Rep, 2023 Doodi R, Gunji BM.
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source