Results 111 to 120 of about 48,587,327 (320)

Evaluation of clinical prediction models (part 3): calculating the sample size required for an external validation study

British medical journal
An external validation study evaluates the performance of a prediction model in new data, but many of these studies are too small to provide reliable answers.
R. Riley, K. Snell, Lucinda Archer, J. Ensor, T. Debray, Ben Van Calster, M. van Smeden, Gary S. Collins   +7 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Validation of Physical Activity Tracking via Android Smartphones Compared to ActiGraph Accelerometer: Laboratory-Based and Free-Living Validation Studies

JMIR mHealth and uHealth, 2015
Background There is increasing interest in using smartphones as stand-alone physical activity monitors via their built-in accelerometers, but there is presently limited data on the validity of this approach.
E. Hekler, M. Buman, Lauren A. Grieco, M. Rosenberger, S. Winter, W. Haskell, A. King   +6 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Validation of the Colombian version of the Karolinska sleepiness scale [PDF]

Sleep Science
Introduction: Currently, daytime sleepiness is a prevalent condition worldwide. Locally validated instruments for measuring sleepiness are required.
María Camila Laverde-López, Franklin Escobar-Córdoba, Javier Eslava-Schmalbach   +2 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Measurement Properties of the Smartphone-Based B-B Score in Current Shoulder Pathologies

Sensors, 2015
This study is aimed at the determination of the measurement properties of the shoulder function B-B Score measured with a smartphone. This score measures the symmetry between sides of a power-related metric for two selected movements, with 100 ...
Claude Pichonnaz, Cyntia Duc, Nigel Gleeson, Céline Ancey, Hervé Jaccard, Estelle Lécureux, Alain Farron, Brigitte M. Jolles, Kamiar Aminian   +8 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Adaptação transcultural do Selection, Optimization and Compensation questionnaire (SOC) para aplicação a idosos

Revista Brasileira de Geriatria e Gerontologia
O artigo descreve a adaptação transcultural do Selection, Optimization and Compensation questionnaire (SOC) para o idioma português, para aplicação a idosos.
Sionara Tamanini de Almeida, Claus Dieter Stobäus, Thais de Lima Resende   +2 more
doaj   +1 more source