Results 151 to 160 of about 4,291,624 (296)

Portuguese version of the CDR plus NACC FTLD: Validation studies. [PDF]

Alzheimers Dement (Amst), 2022
Lima M, Tábuas-Pereira M, Durães J, Faustino P, Simões MR, Kukull W, Knopman DS, Santana I.   +7 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Adaptação transcultural para o português do End of Life Comfort Questionnaire – Patient [Cross-cultural adaptation of the End of Life Comfort Questionnaire-Patient to Brazilian Portuguese]

Revista Enfermagem UERJ, 2014
O objetivo foi validar para o português, falado no Brasil, a escala End of life Comfort Questionnaire-Patient. A validação constituiu-se de tradução, síntese, retrotradução, revisão por comitê de especialistas, pré-teste e verificação das propriedades ...
Liana Amorim Corrêa Trotte, Claudia Feio da Maia Lima, Tamires Luciana do Nascimento Pena, Antônio Milton Oliveira Ferreira, Célia Pereira Caldas   +4 more
doaj  

Confirmatory and validation studies on experimental self-efficacy scale with applications to multiple scientific disciplines. [PDF]

Front Psychol, 2023
Kolil VK, Parvathy SU, Achuthan K.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Systematic Review of Fitbit Charge 2 Validation Studies for Exercise Tracking. [PDF]

Transl J Am Coll Sports Med, 2022
Irwin C, Gary R.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Systematic profiling of conditional degron tag technologies for target validation studies. [PDF]

Nat Commun, 2022
Bondeson DP, Mullin-Bernstein Z, Oliver S, Skipper TA, Atack TC, Bick N, Ching M, Guirguis AA, Kwon J, Langan C, Millson D, Paolella BR, Tran K, Wie SJ, Vazquez F, Tothova Z, Golub TR, Sellers WR, Ianari A.   +18 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Validity studies

European Psychiatry, 1996
openaire   +1 more source