Results 51 to 60 of about 4,605,214 (355)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Primacy of theory? Exploring perspectives on validity in conceptual psychometrics

Frontiers in Psychology
Several conceptions of validity have emphasized the contingency of validity on theory. Here we revisit several contributions to the discourse on the concept of validity, which we consider particularly influential or insightful.
Josh Joseph Ramminger, Josh Joseph Ramminger, Niklas Jacobs   +2 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Sence of Agency: Concept, Structure, Assessment

Вопросы образования
In recent years, the sense of agency has been the subject of interest for researchers in psychology, economics, sociology, political science, and education. To psychologically measure this phenomenon, Adam Tapal and his colleagues developed and validated
Alena M. Kulyapina, Anna H. Fam, Alena A. Zolotareva   +2 more
doaj   +1 more source

The validity of collaborative assessment for learning [PDF]

, 2007
This article explores the features relating to the validity of assessment for learning, in particular the features of a collaborative assessment for learning, because of the learning benefits associated with collaborative learning.
Hargreaves, Eleanore
core   +2 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

How to Assess Oral Narrative Skills of Children and Adolescents with Intellectual Disabilities: A Systematic Review

Behavioral Sciences
Children and adolescents with intellectual disabilities (ID) often encounter difficulties with narrative skills. Yet, there is a lack of research focusing on how to assess these skills in this population.
Victoria Sánchez-Gómez, Miguel Ángel Verdugo, María Isabel Calvo, Antonio M. Amor, Blanca Palomero-Sierra, Laura Zampini   +5 more
doaj   +1 more source

Validating the Need to Validate Code [PDF]

Physics Today, 2005
© 2005 American Institute of Physics, S-0031-9228-0508-220-7 Validating the Need to Validate Code T article “Computational Science Demands a New Paradigm” by Douglass Post and Lawrence Votta (PHYSICS TODAY, January 2005, page 35) makes some good points about the pitfalls of believing computed physics.
openaire   +3 more sources

Robust and efficient validation of the linear hexahedral element

, 2017
Checking mesh validity is a mandatory step before doing any finite element analysis. If checking the validity of tetrahedra is trivial, checking the validity of hexahedral elements is far from being obvious.
Johnen, Amaury, Remacle, Jean-François, Weill, Jean-Christophe   +2 more
core   +1 more source

The translation, validity and reliability of the German version of the Fremantle Back Awareness Questionnaire [PDF]

, 2018
Background: The Fremantle Back Awareness Questionnaire (FreBAQ) claims to assess disrupted self-perception of the back. The aim of this study was to develop a German version of the Fre-BAQ (FreBAQ-G) and assess its test-retest reliability, its known ...
A Vrana, AG Cashin, AV Apkarian, B Wand, Benedict M. Wand, BM Wand, BM Wand, BM Wand, BM Wand, C Ryan, CA McHorney, CG Levenig, Christian Grüneberg, CM Wenig, Cormac G. Ryan, D Beaton, D Rowe, DE Beaton, Denis J. Martin, DG Altman, F Balagué, G Stucki, G. Waddell, GL Moseley, GP Grieve, H Bray, H Flor, H Flor, H Loumajoki, H Luomajoki, HC De Vet, J Bredow, J Kregel, J. Cohen, K Ehrenbrusthoff, K Ehrenbrusthoff, Katja Ehrenbrusthoff, KL Barker, L Fahrmeir, L Janssens, L Portney, L Radbruch, LB Mokkink, M Gutknecht, M Leeuw, M Lotze, M Roland, MF Nolan, MJ Catley, MJ Catley, MP Jensen, P Haggard, P Hodges, P Oesch, PJ Daffada, PW Hodges, R Lauche, RA Deyo, Roger Hilfiker, RP Snaith, S Bot, S Hotz-Boendermaker, T Nishigami, T Nishigami, W Adamczyk, ÉB de Moraes Vieira   +65 more
core   +3 more sources