Results 51 to 60 of about 2,879,474 (307)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Toward Personalized Orthopedic Care: Validation of a Smart Knee Brace
Digital BiomarkersIntroduction: Wearable technology offers a promising solution to advance current rehabilitation strategies for post-operative orthopedic care. The aim of this study was to determine the level of agreement and concurrent validity of a smart knee brace ...
Annah McPherson +2 more
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Development and Psychometric Properties of a Questionnaire to Assess Iranian Women’s Sexual Self-disclosure [PDF]
مراقبت پرستاری و مامایی ابن سیناBackground and Objective: Sexual self-disclosure plays an important role in couples' sexual performance and satisfaction. It is necessary to have a valid, reliable tool to measure this variable. A review of the literature shows that there is no tool with
Raziyeh Maasoumi +2 more
doaj
The Bayesian One-Sample t-Test Supersedes Correlation Analysis as a Test of Validity
European Journal of Psychology Open: Introduction: The validity of measurement, which refers to how accurately tools measure what they are intended to measure, is essential in science. Researchers rely on statistical approaches to test the validity of their measures.
Phivos Phylactou +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source
Verification Strategies for Establishing Reliability and Validity in Qualitative Research
, 2002 The rejection of reliability and validity in qualitative inquiry in the 1980s has resulted in an interesting shift for “ensuring rigor” from the investigator's actions during the course of the research, to the reader or consumer of qualitative inquiry ...
J. Morse +4 more
semanticscholar +1 more source
ABC of Content Validation and Content Validity Index Calculation
Education in Medicine Journal, 2019 There are five sources of validity evidence that are content, response process, internal structure, relation to other variables, and consequences. Content validity is the extent of a measurement tool represents the measured construct and it is considered
M. Yusoff
semanticscholar +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source