Results 51 to 60 of about 2,730,603 (357)
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Validating the Need to Validate Code [PDF]
Physics Today, 2005 © 2005 American Institute of Physics, S-0031-9228-0508-220-7 Validating the Need to Validate Code T article “Computational Science Demands a New Paradigm” by Douglass Post and Lawrence Votta (PHYSICS TODAY, January 2005, page 35) makes some good points about the pitfalls of believing computed physics.
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Neuropsychopharmacology ReportsAim The aim of the study was to identify the clinical significance of anxiety in those with depression, the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM‐5) defined criteria for an anxious distress specifier for major depressive ...
Yumi Aoki +9 more
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Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Electronic Notes in Theoretical Computer Science, 2007 AbstractWe introduce the idea of optimisation validation, which is to formally establish that an instance of an optimising transformation indeed improves with respect to some resource measure. This is related to, but in contrast with, translation validation, which aims to establish that a particular instance of a transformation undertaken by an ...
D. Aspinall, L. Beringer, A. Momigliano
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Insurance: Mathematics and Economics, 2020 Recognizing, quantifying and visualizing associations between two variables is increasingly important. This paper investigates how a new function-valued measure of dependence, the quantile dependence function, can be used to construct tests for independence and to provide an easily interpretable diagnostic plot of existing departures from the null ...
Bogdan Ćmiel, Teresa Ledwina
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Development Strategies in Medical Education, 2016 Introduction: Predictive validity is one of important characteristics of a test; it means that what extent a test predicts scores of criterion test. This type of validity can be obtained through determining correlation between scores of two tests.
Akbar Pirzadeh +4 more
doaj
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source