Results 1 to 10 of about 30,415 (128)

Longitudinal Australian trends in the initiation of valproate medication among women of reproductive age and concurrent use of prescription contraceptives [PDF]

Women's Health
Background: Awareness of the risks of prescribing valproate to girls and women of childbearing potential has increased, with some countries strongly restricting prescribing and requiring pregnancy prevention plans.
Mumtaz Begum, Lynne Giles, Jenni Ilomaki, Alice Rumbold, Michael Davies, Luke E Grzeskowiak, Vivienne Moore   +6 more
doaj   +2 more sources

Valproate induced hyperammonemic encephalopathy: a rare adverse effect of a common drug [PDF]

Romanian Journal of Neurology, 2023
Introduction. Sodium valproate or Valproic acid (VPA) is routinely used in management of epilepsy in neurology practice. It is a well-tolerated drug with mild side effects.
Sanaullah Mudassir, Deepa N.A., Prashant Kumar Thakur   +2 more
doaj   +1 more source

Alpha-lipoic acid ameliorates sodium valproate-induced liver injury in mice [PDF]

Veterinary World, 2020
Aim: This study examines the effect of alpha-lipoic acid (ALA) on sodium valproate-induced liver injury through histological features of mice liver tissue.
Chrismawan Ardianto, Hijrawati Ayu Wardani, Nurrahmi Nurrahmi, Mahardian Rahmadi, Junaidi Khotib   +4 more
doaj   +1 more source

Evaluation of Free Valproate Concentration in Critically Ill Patients

Critical Care Explorations, 2022
OBJECTIVES:. Protein binding of valproate is variable in ICU patients, and the total valproate concentration does not predict the free valproate concentration, even when correcting for albumin. We sought to quantify valproate free concentration among ICU
Caitlin S. Brown, PharmD, BCCCP, JiTong Liu, PharmD, Richard R. Riker, MD, FCCM, Kristin C. Mara, MS, Alejandro A. Rabinstein, MD, Gilles L. Fraser, PharmD, MCCM, Teresa L. May, DO, David Seder, MD, FCCM, David J. Gagnon, PharmD, BCCCP, FCCM   +8 more
doaj   +1 more source

Reversible male infertility with valproate use: A review of the literature

Epilepsy & Behavior Reports, 2021
Sodium valproate is a broad spectrum anti-seizure medication useful in the treatment of both generalized and focal epilepsies. The association between valproate and female reproductive disorders is well understood and delineated. Male infertility however
Eva Tallon, Louise O'Donovan, Norman Delanty   +2 more
doaj   +1 more source

Case Report: A Case of Valproic Acid-Induced Hyperammonemic Encephalopathy Associated With the Initiation of Lithium: A Re-duplicable Finding

Frontiers in Psychiatry, 2022
IntroductionHyperammonemic encephalopathy (HAE) is a serious adverse effect of valproate semisodium, which is facilitated by the potential for drug interaction.
Anna Levy, Etienne Very, Etienne Very, François Montastruc, Philippe Birmes, Philippe Birmes, Adeline Jullien, Louis Richaud   +7 more
doaj   +1 more source

Entry of antiepileptic drugs (valproate and lamotrigine) into the developing rat brain [version 2; peer review: 2 approved, 1 approved with reservations]

F1000Research, 2021
Background: Women with epilepsy face difficult choices whether to continue antiepileptic drug treatment during pregnancy, as uncontrolled seizures carry great risk to mother and fetus but continuing treatment may have adverse effects on baby’s ...
Samuel J. Toll, Fiona Qiu, Yifan Huang, Mark D. Habgood, Katarzyna M. Dziegielewska, Shuai Nie, Norman R. Saunders   +6 more
doaj   +1 more source

Valproate for schizophrenia [PDF]

Cochrane Database of Systematic Reviews, 2016
Many people with schizophrenia do not achieve a satisfactory treatment response with ordinary antipsychotic drug treatment. In these cases, various add-on medications are used, and valproate is one of these.To examine whether:1. valproate alone is an effective treatment for schizophrenia and schizoaffective psychoses; and2.
Yijun, Wang, Jun, Xia, Bartosz, Helfer, Chunbo, Li, Stefan, Leucht   +4 more
openaire   +2 more sources

Severe fatigue due to valproate-induced hypothyroidism in a case of bipolar disorder

Annals of General Psychiatry, 2020
Background Valproate-induced hypothyroidism is a rare condition and has been considered asymptomatic. Here, we report a case of bipolar I disorder who developed symptomatic valproate-induced hypothyroidism.
Tadashi Kanamori, Masahiro Suzuki, Yoshiyuki Kaneko, Kouju Yamada, Hideyuki Kubo, Makoto Uchiyama   +5 more
doaj   +1 more source

Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo

Molecular Brain, 2021
Machado-Joseph disease (MJD, also known as spinocerebellar ataxia type 3) is a fatal neurodegenerative disease that impairs control and coordination of movement.
Maxinne Watchon, Luan Luu, Katherine J. Robinson, Kristy C. Yuan, Alana De Luca, Hannah J. Suddull, Madelaine C. Tym, Gilles J. Guillemin, Nicholas J. Cole, Garth A. Nicholson, Roger S. Chung, Albert Lee, Angela S. Laird   +12 more
doaj   +1 more source