Results 101 to 110 of about 5,054,451 (380)
HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]
, 2010 Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan +54 more
core +1 more source
Are Strong Bronsted Acids Necessarily Strong Lewis Acids? [PDF]
arXiv, 2006 The Broensted and Lowry acid base theory is based on the capacity of proton donation or acceptance (in the presence or absence of a solvent) whereas the Lewis acid base theory is based on the propensity of electron pair acceptance or donation. We explore through DFT calculation the obvious question whether these two theories are in conformity with each
arxiv
Epileptic Disorders, EarlyView.Abstract Background Alternating Hemiplegia of Childhood (AHC) is a severe channelopathy that manifests before 18 months of age, primarily caused by pathogenic variants in the ATP1A3 gene. It is characterized by recurrent and disabling episodes of plegia, dystonia, dysautonomia, along with chronic neurological features and cardiac arrhythmias. About 50%
Ramona Cordani +8 more
wiley +1 more source
HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers [PDF]
, 2006 Valproic acid (VPA), a histone deacetylase inhibitor, causes differentiation in different cell lines and in a cell-specific manner; yet, its effect on megakaryocytic (MK) differentiation has not been studied.
Ciccarelli, Carmela +9 more
core
Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]
, 2017 Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana +5 more
core +1 more source
The Factors of the Classification of Protein Amino Acids [PDF]
This paper is published in GLASNIK of Montenegrin Academy of
Science and arts, 2000, 13, pp. 173-194, 2006 In this work it is shown that three pairs of the factors appear to be the key, i.e. main factors of a natural classification of protein (canonical) amino acids within the amino acid (genetic) code. First pair: the factors of the habit of an amino acid molecule (size and polarity).
arxiv
Journal of Clinical Oncology, 2016 PURPOSE Symptomatic epilepsy is a common complication of glioblastoma and requires pharmacotherapy. Several uncontrolled retrospective case series and a post hoc analysis of the registration trial for temozolomide indicated an association between ...
C. Happold +14 more
semanticscholar +1 more source
Analisis Asam Valproat Dalam Plasma Secara Kromatografi Gas [PDF]
, 2010 Valproic acid is an anticonvulsant drug that works by increasing the levels ofγ-aminobutyric acid (GABA). Determination of valproic acid is quite difficultbecause it has no chromophore groups in its structure.
Harahap, Y. (Yahdiana) +2 more
core
Valproic Acid and Thrombocytopenia
Pediatric Neurology Briefs, 1996 The association of thrombocytopenia (TCP) with valproic acid (VPA) therapy was evaluated retrospectively in 167 children treated with VPA between 1989 and 1993 at the Department of Pediatrics, Henry Ford Medical Center, Detroit, MI.
openaire +4 more sources
Epileptic Disorders, EarlyView.Abstract Objective Some children with Childhood Absence Epilepsy (CAE) exhibit focal abnormalities similar to those observed in Self‐Limited Focal Epilepsies of Childhood (SeLFEs). It remains unclear whether this subgroup of patients may present distinct clinical characteristics or prognoses compared to those with CAE and generalized discharges alone ...
Giulia Barbagallo +6 more
wiley +1 more source