Results 131 to 140 of about 5,054,451 (380)

Valproic Acid and Other HDAC Inhibitors Upregulate FGF21 Gene Expression and Promote Process Elongation in Glia by Inhibiting HDAC2 and 3

International Journal of Neuropsychopharmacology, 2016
Background: Fibroblast growth factor 21, a novel regulator of glucose and lipid metabolism, has robust protective properties in neurons. However, its expression and function in glia are unknown.
Y. Leng, Junyu Wang, Zhifei Wang, Hsiao-Mei Liao, M. Wei, P. Leeds, D. Chuang   +6 more
semanticscholar   +1 more source

Decreased homovanillic acid and 5‐hydroxyindoleacetic acid levels in the cerebrospinal fluid of patients with Dravet syndrome with parkinsonism

Epilepsia Open, EarlyView.
Abstract Dravet syndrome (DS) is an early onset, developmental, and epileptic encephalopathy characterized by drug‐resistant seizures and multiple comorbidities. It has been reported that in adulthood, it may be accompanied by parkinsonism, but the pathogenesis of this condition remains unclear.
Ryo Sugiyama, Takashi Saito, Atsuko Katsumoto, Shota Yoneno, Tomoyuki Akiyama, Hirofumi Komaki   +5 more
wiley   +1 more source

Linguistic mechanism of the evolution of amino acid frequencies and genomic GC content [PDF]

arXiv, 2006
Much information is stored in amino acid composition of protein and base composition of DNA. We simulated the evolution of amino acid frequencies and genomic GC content by a linguistic model. It is showed that the evolution of genetic code determines the evolution of amino acid frequencies and genomic GC content.
arxiv  

MECP2 duplication syndrome—Typical EEG characteristics

Epileptic Disorders, EarlyView.
Walter Otu, Ritu Sudhakaran, German Garza‐Garcia, Krishna Parekh, Irfan S. Sheikh   +4 more
wiley   +1 more source

Effects of perampanel on bone health in adult patients with epilepsy

Epilepsia Open, EarlyView.
Abstract Objective The objective was to assess the effects of perampanel (PER) on bone metabolism and bone mineral density (BMD) in adult patients with epilepsy. Methods This retrospective study included consecutive patients admitted to the Epilepsy Center of Sichuan Provincial People's Hospital from January 2023 to June 2024.
Mingxing Yu, Nana Zhang, Chunyan Chen, Yuxuan He, Jing Meng, Wen Luo, Yi Liang, Yi Guo, Liang Yu   +8 more
wiley   +1 more source

Genetic Code Table: A note on the three splittings into amino acid classes [PDF]

arXiv, 2009
This note represents the further progress in understanding the determination of the genetic code by Golden mean (Rakocevic, 1998). Three classes of amino acids that follow from this determination (the 7 "golden" amino acids, 7 of their complements, and 6 non-complements) are observed now together with two further possible splittings into 4 x 5 and 5 x ...
arxiv  

L-Carnitine supplementation to reverse hyperammonemia in a patient undergoing chronic valproic acid treatment: A case report

Journal of International Medical Research, 2017
Valproic acid is a broad-spectrum anticonvulsant that has also gained attention in the psychiatric setting. With respect to safety, valproic acid may induce a seemingly rare condition, hyperammonemia, which can induce a wide variety of symptoms ranging ...
Cecilia Maldonado, Natalia Guevara, A. Silveira, P. Fagiolino, M. Vázquez   +4 more
semanticscholar   +1 more source

Cerebral blood flow increases in idiopathic generalized epilepsy and its relationship with mood dysfunction

Epilepsia Open, EarlyView.
Abstract Objective To investigate the relationship between cerebral blood flow (CBF), seizure control, and mood regulation in idiopathic generalized epilepsy (IGE), we hypothesized that higher CBF in mood‐regulating regions would be associated with greater mood disturbance, particularly in patients with poor seizure control.
Yun Lien, Ayushe A. Sharma, William R. Willoughby, Anna Moyana, Jennifer Pilkington, Ja’ Kaiya Bryant, Adam M. Goodman, Goutham Selladurai, Lawrence W. Ver Hoef, Jerzy P. Szaflarski, Jane B. Allendorfer   +10 more
wiley   +1 more source

Analytical validation of therapeutic drug monitoring (TDM) on AxSYM Abbott analyzer [PDF]

, 2010
Introduction: Careful monitoring of drug concentration (therapeutic drug monitoring, TDM) is essential for a large number of drugs. The aim of this study was to evaluate analytical performance of Abbott AxSYM analyzer for therapeutic drug monitoring of ...
Ana-Maria Simundic, Dalja Papic Futac, Nada Vrkic, Nada Vukelic, Nora Nikolac   +4 more
core   +2 more sources

Uncoupling in a child with tonic seizures

Epileptic Disorders, EarlyView.
Émilie Groulx‐Boivin, Kenneth A. Myers   +1 more
wiley   +1 more source