Results 181 to 190 of about 5,054,451 (380)

Can the large language model ChatGPT‐4omni predict outcomes in adult patients with status epilepticus?

open access: yesEpilepsia, Volume 66, Issue 3, Page 674-685, March 2025.
Abstract Objective Large language models (LLMs) have recently gained attention for clinical decision‐making and diagnosis. This study evaluates the performance of the recently updated LLM Chat Generative Pre‐Trained Transformer‐4omni (ChatGPT‐4o) in predicting clinical outcomes in patients with status epilepticus and compares its prognostic performance
Simon A. Amacher   +10 more
wiley   +1 more source

VALPROIC ACID PROTECTS KIDNEYS FROM CISPLATIN [PDF]

open access: yes
Cisplatin treatment is effective against several types of carcinomas. However, it frequently leads to kidney injury, which warrants effective prevention methods.
Aizawa, Fuka   +13 more
core  

Fragile X syndrome. [PDF]

open access: yes, 2014
Fragile X Syndrome (FXS) is a genetic disease due to a CGG trinucleotide expansion, named full mutation (greater than 200 CGG repeats), in the fragile X mental retardation 1 gene locus Xq27.3; which leads to an hypermethylated region in the gene promoter
Ayala-Zapata, Sebastián   +5 more
core   +1 more source

SCN1A pathogenic variants do not have a distinctive blood‐derived DNA methylation signature

open access: yesEpilepsia, Volume 66, Issue 4, Page e66-e72, April 2025.
Abstract DNA methylation signatures (“episignatures”) can be used as biomarkers of genetic aberrations, clinical phenotypes, and environmental exposures in rare diseases. Episignatures are utilized in molecular diagnostics and can clarify variants of uncertain significance. A growing number of disease genes, including epilepsy genes, exhibit robust and
Christy W. LaFlamme   +14 more
wiley   +1 more source

Serum carnitine, beta-hydroxybutyrate and ammonia levels during valproic acid therapy

open access: yesThe Turkish Journal of Pediatrics, 1995
This study was performed in order to determine the effects of valproic acid on serum free carnitine, beta-hydroxybutyrate and blood amamonia.
H B Toksoy, F N Tanzer, A Atalay
doaj  

Evaluation of antiseizure medication concentration ranges in blood samples using an automated big data approach

open access: yesEpilepsia, EarlyView.
Abstract Objective The aim of the study is to provide insight into the real‐world use of therapeutic drug monitoring (TDM) for the most common antiseizure medications (ASMs). Methods In total, 137 586 samples from the period 2019–2023 were collected from the five main Danish laboratories performing TDM.
Mariam Nersesjan   +10 more
wiley   +1 more source

Possible teratogenic effect of valproic acid

open access: bronze, 1981
Susan Clay, Robert McVie, Harold Chen
openalex   +1 more source

Valproic acid-associated pancreatitis: report of three cases and a brief review [PDF]

open access: bronze, 1990
John Lott   +4 more
openalex   +1 more source

Comparative risk of major health events among individuals prescribed different antiseizure medications following ischemic stroke

open access: yesEpilepsia, EarlyView.
Abstract Objective The aim of this study was to compare the risk of seizure, recurrent stroke, fall or fracture, and mortality in individuals prescribed different antiseizure medications (ASMs) following an ischemic stroke. Methods We identified all patients admitted to a Victorian public or private hospital with a principal diagnosis of an incident ...
Stella Jung‐Hyun Kim   +4 more
wiley   +1 more source

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