The multiple hit model of infantile and epileptic spasms: The 2025 update
Epilepsia Open, EarlyView.Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou +6 more
wiley +1 more source
Cells, 2019 Acute myeloid leukemia (AML) is an aggressive malignancy, and many elderly/unfit patients cannot receive intensive and potentially curative therapy. These patients receive low-toxicity disease-stabilizing treatment.
Ida Sofie Grønningsæter +4 more
doaj +1 more source
Normalization And Matching Of Chemical Compound Names [PDF]
, 2011 We have developed ChemHits (http://sabio.h-its.org/chemHits/), an application which detects and matches synonymic names of chemical compounds. The tool is based on natural language processing (NLP) methods and applies rules to systematically normalize ...
Henriette Slogsnat +6 more
core +2 more sources
A multi‐feature method for real‐time seizure detection in pediatric intensive care unit
Epilepsia Open, EarlyView.Abstract Purpose Continuous electroencephalogram (cEEG) monitoring is an important technique used in detecting electroclinical seizures in the pediatric intensive care unit (PICU). This study developed an artificial intelligence method for the real‐time automatic detection of seizures in the PICU.
Tian Sang +10 more
wiley +1 more source
Teratogenic effects of gabapentin on neural tube and limb development in mice [PDF]
, 2008 [No abstract ...
Afshar, M., Golalipour, M.J.
core
The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing. [PDF]
, 2013 BACKGROUND: Histone deacetylase inhibitors (HDACi) cause histone hyperacetylation and H3K4 hypermethylation in various cell types. They find clinical application as anti-epileptics and chemotherapeutic agents, but the pathways through which they operate ...
Boudadi, Elsa +8 more
core +4 more sources
Epilepsia Open, EarlyView.Abstract Objective Status epilepticus (SE) is a neurological emergency requiring immediate treatment. Although intravenous lacosamide (LCM) is used for the management of epilepsy, its effectiveness in treating SE remains unclear. We aimed to compare the in‐hospital outcomes between intravenous LCM and levetiracetam (LEV) as an early adjunctive therapy ...
Yumiko Nakamura +8 more
wiley +1 more source
Anti-tumor effects of valproic acid and 1, 25 dihydroxy vitamin D3 on HL-60 cancer cells
یافتههای نوین در علوم زیستی, 2018 11, 25 dihydroxy vitamin D3, an active metabolite of vitaminD3 has been reported to inhibit the growth of number neoplasms such as prostate, breast, colorectal, leukemia and skin cancers.
Maryam Rihimi
doaj
Reversible central respiratory events induced by valproic acid treatment: A case report
SAGE Open Medical Case ReportsValproic acid holds a prominent position as the primary therapeutic option for epilepsy cases. The utilization of antiepileptic agents like valproic acid has been linked to disturbances in sleep architecture.
Chirine Moussa +7 more
doaj +1 more source
Adverse effect of valproic acid on mating behaviour and fertility in Drosophila melanogaster [PDF]
, 2012 Drosophila melanogaster, the model organism that has been widely used to study various diseases and also the adverse effects. D. melanogaster can be extrapolated to human system which could facilitate the effect of drugs on reprodn.
Gayathri, D.S., Harini, B.P.
core