Results 91 to 100 of about 3,866,137 (303)

Value Added Taxes, Chain Effects and Informality [PDF]

This paper investigates determinants of informal economic activity. We present an equilibrium model of informality and test its implications using a survey of 48,000+ small firms in Brazil.
Aureo de Paula, Jose A. Scheinkman
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Digital Innovation Through Behavioural Analytics: Evidence from Acquisition Channels and Engagement in Global Cruise Firms

Information
Digital transformation has reshaped how cruise firms acquire, engage and retain customers. However, existing research rarely integrates these behavioural dimensions within a unified analytical framework.
Dimitrios P. Reklitis, Nikolaos T. Giannakopoulos, Marina C. Terzi, Damianos P. Sakas, Stylianos K. Tountas, Nikos Kanellos, Panagiotis Reklitis   +6 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The LESG Index for Assessing Structural Coherence in National Development Systems

Applied Sciences
This study introduces the LESG index, a composite analytical framework designed to assess the structural coherence of national development systems by integrating logistics capability, governance quality, and sustainability performance.
Panagiotis Karountzos, Damianos P. Sakas, Kanellos S. Toudas, Pandora P. Nika, Nikolaos T. Giannakopoulos   +4 more
doaj   +1 more source

Vertical Aliances between Retail and Manufacturer Companies in the Fashion Industry [PDF]

While vertical firms dominate the fashion markets worldwide since years, only little research is done on vertical alliances between non-vertical retailer and manufacturing companies in this sector.
Bernhard Swoboda, Dan Cristian Dabija, Nicolae Al. Pop   +2 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Behavioral Economics in EU: Meat, ESG, Macroeconomics

Economies
This study examines the impact of macroeconomic and ESG (Environmental, Social, and Governance) factors on meat consumption in EU countries through a behavioral economics framework.
Panagiotis Karountzos, Nikolaos T. Giannakopoulos, Damianos P. Sakas, Kanellos Toudas   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Supply Chain Management in the Life Science Sector: Does Trust Play a Role? [PDF]

Supply chain management has emerged as cross functional, cross company concept to improve coordination of entire value chains through coordinated actions of all companies in the value chain.
Fritz, Melanie, Hausen, Tobias
core   +1 more source