Results 101 to 110 of about 19,210,102 (353)

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Engineering Human Values in Software through Value Programming [PDF]

arXiv, 2020
Ignoring human values in software development may disadvantage users by breaching their values and introducing biases in software. This can be mitigated by informing developers about the value implications of their choices and taking initiatives to account for human values in software.
arxiv  

Patient interpretations of patient-reported outcome measures to assess bowel urgency: qualitative interviews in ulcerative colitis

Journal of Patient-Reported Outcomes
Objectives Bowel urgency is an impactful core symptom of ulcerative colitis (UC). Patient-reported outcome (PRO) questionnaires have been developed and used to assess the patient experience of this important symptom.
Vipul Jairath, Theresa Hunter Gibble, Richard Moses, Brittany Klooster, Leighann Litcher-Kelly, Marisa Walker, Madison C Bernstein, Kaelyn Rupinski, Megan McLafferty, Simon Travis, Marla Dubinsky   +10 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Weak Values with Decoherence

, 2009
The weak value of an observable is experimentally accessible by weak measurements as theoretically analyzed by Aharonov et al. and recently experimentally demonstrated.
Aharonov Y, Aharonov Y, Aharonov Y, Akio Hosoya, Beyer R T, Braginsky V B, Busch B, Gardiner C W, Itô K, Nielsen M A, Ozawa M, Parks A D, Parks A D, Shapere A, Tamate S, Uhlmann A, von Neumann J, Yokota K, Yutaka Shikano   +18 more
core   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Anthropocentric Realism about Values [PDF]

, 2014
31 The choice of human goals cannot be completely subjective, because 32 there are some (even ones that motivate many humans) that are simply 33 unintelligible as ultimate goals.
Van Norden, Bryan
core  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Single-valued periods and multiple zeta values [PDF]

arXiv, 2013
The values at 1 of single-valued multiple polylogarithms span a certain subalgebra of multiple zeta values. In this paper, the properties of this algebra are studied from the point of view of motivic periods.
arxiv