Results 41 to 50 of about 14,939,646 (305)
Was Benedictine monasticism conservative? Evidence from the sermon collection of Jacques de Furnes, abbot of Saint-Berlin (1230-1237) [PDF]
, 2017 The failure of papal attempts to impose the governmental structures of the religious orders on Benedictine monasticism in the early thirteenth century has long been considered a consequence of a typically Benedictine independent attitude. More precisely,
Belaen, Johan
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Van’da Bulunan Osmanlı Vakıfları
Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2021 Van’ı 1548 yılında tam olarak hâkimiyeti altına alan Osmanlı Devleti şehrin askerî, siyasî, iktisadî, sosyal, kültürel, dinî ve eğitim ihtiyaçlarını karşılamak için çeşitli eserler bina ettirmiştir.
Sami Ağaoğlu
doaj
The Image of the City in Armenia: Anthropological Perspective
Urbis et Orbis: Mikroistoriâ i Semiotika Goroda, 2023 Socially significant phenomena are usually personified and embodied in the images of ancestors, ethnarchs, and heroes. The anthropomorphic symbol in the fine arts was an integral part of ancient Greek culture from the very beginning.
Viktorya Vasilyan
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
MAIN MYTHS RELATED TO THE LAKE VAN BASIN (PRELIMINARY ATTEMPT OF CLASSIFICATION AND TYPOLOGICAL DIFFERENTIATION OF MYTHOLOGICAL NARRATIVES) [PDF]
Banber Arevelagitut'yan Instituti, 2019 As known, geographical environment, climatic conditions stipulate any region’s population’s culture and mythological imagination to a significant extent.
HASMIK HMAYAKYAN
doaj
Agrobacterium-mediated transformation of Mycosphaerella fijiensis, the devastating Black Sigatoka pathogen of bananas [PDF]
, 2010 Mycosphaerella fijiensis, M. musicola en M. eumusae veroorzaken de Sigatoka-ziekte in banaan. Op dit moment is de toepassing van fungiciden de enige optie om deze ziekte te bestrijden.
Adibon, H. +5 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Lacan’s discourse theory in the age of evidence-based practice [PDF]
, 2006 Deze lezing vergelijkt de hedendaagse empirisch-kwantitatieve benadering omtrent effectiviteit van psychotherapieën met een bestudering van de effecten van psychotherapie aan de hand van de Lacaniaanse discourstheorie.
Desmet, Mattias
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source