Results 101 to 110 of about 138,627 (294)

Microbiome‐Informed Dosing: Exploring Gut Microbial Communities Impact on Mycophenolate Enterohepatic Circulation and Therapeutic Target Achievement

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacomicrobiomics is an emerging field due to important microbiome effects on pharmacokinetics and clinical outcomes. However, the application of this knowledge remains limited. Mycophenolic acid (MPA) is the primary active metabolite of the immunosuppressant, mycophenolate mofetil (MMF).
Abdelrahman Saqr, Shen Cheng, Mahmoud Al‐Kofahi, Christopher Staley, Pamala A. Jacobson   +4 more
wiley   +1 more source

Contactless Conductivity Detection for Capillary Electrophoresis—Developments From 2020 to 2024

ELECTROPHORESIS, EarlyView.
ABSTRACT The review covering the development of capillary electrophoresis with capacitively coupled contactless conductivity detection from 2020 to 2024 is the latest in a series going back to 2004. The article considers applications employing conventional capillaries and planar lab‐on‐chip devices as well as fundamental and technical developments of ...
Peter C. Hauser, Pavel Kubáň
wiley   +1 more source

Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials

Exploration, EarlyView.
Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment, has been emerging as a key participant and driving factor in cancer. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral ...
Yanan Niu, Junya Feng, Jie Ma, Tixian Xiao, Wei Yuan   +4 more
wiley   +1 more source

Microbiota humanization drives human‐like metabolic and immune transcriptomic shifts in pigs

iMetaOmics, EarlyView.
This study successfully established gut microbiota‐humanized pigs, achieved human‐like remodeling of the serum metabolome, and uncovered transcriptional alterations in immune cell subsets. These findings advance our understanding of how human gastrointestinal microorganisms affect host metabolism and the immune function in a porcine model.
Zhaoqi Zhang, Yanan Xu, Kun Pang, Changhong Wu, Chenxu Zhao, Tong Lei, Jiayu Zhang, Tang Hai, Fangqing Zhao, Yong Zhao   +9 more
wiley   +1 more source

Vancomycin Induction of L Colonies of Staphylococcus aureus [PDF]

, 1971
Chatrchai Watanakunakorn
openalex   +1 more source

Maternal gut microbiota‐derived daidzein prevents osteoporosis in female offspring following prenatal prednisone exposure

iMeta, EarlyView.
Prenatal prednisone therapy (PPT)/prenatal prednisone exposure (PPE) induces long bone dysplasia, reduced peak bone mass (PBM), and increased osteoporosis susceptibility in female offspring. Maternal gut microbiota metabolite daidzein (DAI) mediates PPE‐induced osteoporosis susceptibility in female adult offspring.
Chi Ma, Hangyuan He, Kunpeng Wang, Juanjuan Guo, Liang Liu, Yuting Chen, Bin Li, Hao Xiao, Xufeng Li, Xiaoqian Lu, Tingting Wang, Yinxian Wen, Hui Wang, Liaobin Chen   +13 more
wiley   +1 more source

A Genetic Locus in Elizabethkingia anophelis Associated with Elevated Vancomycin Resistance and Multiple Antibiotic Reduced Susceptibility

Antibiotics
The Gram-negative Elizabethkingia express multiple antibiotic resistance and cause severe opportunistic infections. Vancomycin is commonly used to treat Gram-positive infections and has also been used to treat Elizabethkingia infections, even though Gram-
William L. Johnson, Sushim Kumar Gupta, Suman Maharjan, Randy M. Morgenstein, Ainsley C. Nicholson, John R. McQuiston, John E. Gustafson   +6 more
doaj   +1 more source

Gut microbiota‐derived butyric acid regulates calcific aortic valve disease pathogenesis by modulating GAPDH lactylation and butyrylation

iMeta, EarlyView.
Multi‐omics sequencing and correlation analysis identified the beneficial role of Faecalibacterium prausnitzii (F. prausnitzii)‐derived butyric acid (BA) as a key metabolite in the restoration of valve function in calcific aortic valve disease (CAVD). The therapeutic efficacy of BA in attenuating CAVD progression was confirmed in vitro, ex vivo, and in
Chunli Wang, Zongtao Liu, Tingwen Zhou, Jiaqin Wu, Fan Feng, Shunshun Wang, Qingjia Chi, Yongqiang Sha, Shuai Zha, Songren Shu, Linghang Qu, Qianqian Du, Huiming Yu, Li Yang, Anna Malashicheva, Nianguo Dong, Fei Xie, Guixue Wang, Kang Xu   +18 more
wiley   +1 more source

Quantitation of the Action of Ethylenediaminetetraacetic Acid and Tris(hydroxymethyl)aminomethane on a Gram-Negative Bacterium by Vancomycin Adsorption [PDF]

, 1970
Donald F. Haslam, Gary K. Best, Norman N. Durham   +2 more
openalex   +1 more source

Gut microbial‐derived 3,4‐dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome

iMeta, EarlyView.
By integrating multi‐level and multi‐omics analyses, we identify 3,4‐dihydroxyphenylacetic acid (DHPAA), a gut microbiota‐derived degradation product of dietary flavonoids, as a key bioactive end‐product responsible for the beneficial effects against polycystic ovary syndrome (PCOS).
Pan Li, Li Xie, Huimin Zheng, Yinglin Feng, Feihong Mai, Wenli Tang, Jiajia Wang, Zixin Lan, Shuaijun Lv, Thisun Jayawardana, Sabrina Koentgen, Shuangbin Xu, Zhengwei Wan, Yunjie Chen, Haiyan Xu, Sj Shen, Fan Zhang, Yuanhao Yang, Georgina Hold, Fangjie He, Emad M. El‐Omar, Guangchuang Yu, Xia Chen   +22 more
wiley   +1 more source