Results 91 to 100 of about 302,754 (340)

In-vitro evaluation of different antimicrobial combinations with and without colistin against carbapenem-resistant acinetobacter baumannii [PDF]

, 2019
Carbapenem-resistant Acinetobacter baumannii (CR-Ab) infections are associated with high morbidity and mortality. The aim of the study was to evaluate the in-vitro activity of different antimicrobial combinations (with and without colistin, COL) against ...
De Angelis, Massimiliano, Garzoli, Stefania, Marzuillo, Carolina, Mastroianni, Claudio M., Oliva, Alessandra, Ragno, Rino, Vullo, Vincenzo   +6 more
core   +1 more source

A Photothermal‐Responsive PRP‐Loaded Hydrogel Engineered With Composite Nanobottle for Controllable Delivery of Growth Factors and Multifunctional Therapy of Diabetic Wounds

Advanced Science, EarlyView.
A photothermal‐responsive engineered platelet‐rich plasma hydrogel (CNB‐ePRP) incorporated with thrombin‐functionalized composite nanobottle was developed, which enables in situ PRP activation, on‐demand growth factor release, multifunctionality, and personalized antimicrobial loading for treatment of diabetic wounds. The CNB‐ePRP hydrogel demonstrated
Wen‐Qiang Qu, Hui‐Yun Gu, Si‐Min Zeng, Chang‐Jiang Liu, Xiao Yan, Ting Pan, Chao Jian, Xian‐Zheng Zhang, Ai‐Xi Yu   +8 more
wiley   +1 more source

Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol‐Induced Intestinal Injury via Microbiota‐Dependent and ‐Independent AHR Activation

Advanced Science, EarlyView.
Glucuronolactone (GLU) as a natural metabolite of glucose, increases Lactobacillus amylovorus abundance and luminal IAA level to activate AHR signaling. In addition, GLU itself can directly elevate AHR signaling activity independently of microbiota and IAA.
Chenbin Cui, Beibei Zhang, Jiaxi Tang, Jing Hou, Yueqin Qiu, Kaiguo Gao, Li Wang, Zongyong Jiang, Xuefen Yang   +8 more
wiley   +1 more source

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

Nature Communications, 2018
The public health threat posed by a looming ‘post-antibiotic’ era necessitates new approaches to antibiotic discovery. Drug development has typically avoided exploitation of membrane-binding properties, in contrast to nature’s control of biological ...
M. Blaskovich, Karl A. Hansford, Yujing Gong, M. Butler, C. Muldoon, Johnny X. Huang, Soumya Ramu, Alberto B. Silva, Mu Cheng, Angela M. Kavanagh, Z. Ziora, Rajaratnam Premraj, Fredrik Lindahl, Tanya Bradford, June-Chul Lee, T. Karoli, Ruby Pelingon, David J. Edwards, Maite Amado, Alysha G. Elliott, Wanida Phetsang, Noor Huda Daud, Johan E. Deecke, H. Sidjabat, Sefetogi Ramaologa, J. Zuegg, Jason R. Betley, Andrew P. G. Beevers, R. Smith, J. Roberts, D. Paterson, M. Cooper   +31 more
semanticscholar   +1 more source

Optimizing Vancomycin Dosing in Chronic Kidney Disease by Deriving and Implementing a Web-Based Tool Using a Population Pharmacokinetics Analysis. [PDF]

, 2019
Background: Chronic kidney disease (CKD) patients requiring intravenous vancomycin bear considerable risks of adverse outcomes both from the infection and vancomycin therapy itself, necessitating especially precise dosing to avoid sub- and ...
Chae, Jung-Woo, Chan, Alexandre, Dorajoo, Sreemanee Raaj, Goh, Jessica Hui Fen, Lee, Siok Ying, Ooi, Say Tat, Somani, Jyoti, Winata, Chrystal Leandra, Yap, Chun Wei, Yeoh, Lee Ying   +9 more
core  

Faecal microbiota transplantation : a regulatory hurdle? [PDF]

, 2017
During faecal microbiota transplantation, stool from a healthy donor is transplanted to treat a variety of dysbiosis-associated gut diseases. Competent authorities are faced with the challenge to provide adequate regulation.
De Spiegeleer, Bart, Janssens, Yorick, Verbeke, Frederick, Wynendaele, Evelien   +3 more
core   +2 more sources

Self‐Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication

Advanced Science, EarlyView.
This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao, Shaolong Qiu, Jiangli Cao, Jifeng Liu, Zhiyong Song, Ting Du, Xinjun Du   +6 more
wiley   +1 more source

Vancomycin Revisited - 60 years later

Frontiers in Public Health, 2014
Vancomycin is one of the older antibiotics that has been now in clinical use close to 60 years. Earlier on, vancomycin was associated with many side effects including vestibular and renal, most likely due to impurities contained .in early vancomycin lots.
Ethan eRubinstein, Yoav eKeynan
doaj   +1 more source

Current Strategies in Prevention of Postoperative Infections in Spine Surgery. [PDF]

, 2020
Study Design: Narrative review. Objectives: Postoperative surgical site infections (SSIs) are among the most common acute complications in spine surgery and have a devastating impact on outcomes. They can lead to increased morbidity and mortality as well
Atesok, Kivanc, Gokaslan, Ziya L, Heffernan, Michael J, Papavassiliou, Efstathios, Pittman, Jason, Rajaram, Sakthivel, Sitnikov, Irina, Tanaka, Nobuhiro, Theiss, Steven, Tunmire, Danny, Vaccaro, Alexander   +10 more
core   +1 more source

Transfer of antibiotic resistance in Staphylococcus aureus [PDF]

, 2017
Staphylococcus aureus is a serious human pathogen with remarkable adaptive powers. Antibiotic-resistant clones rapidly emerge mainly by acquisition of antibiotic-resistance genes from other S. aureus strains or even from other genera.
Haaber, Jakob, Ingmer, Hanne, Penadés, José R.   +2 more
core   +1 more source